Diabetic Foot Ulcer Clinical Unit
Official title: NIDDK Diabetic Foot Consortium Clinical Research Unit
Funded at University of Michigan at Ann Arbor · NIH-11257687 · Data updated 2026-11-12
This program aims to bring quick bedside tests (biomarkers) into clinics to help people with diabetes and foot ulcers get faster, clearer care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 15, 2018 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $727,080 |
| NIH project number | 5U01DK119083-09 |
| Project ID | NIH-11257687 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diabetes who currently have or recently healed diabetic foot ulcers, or who are receiving care at participating wound clinics, are the most likely candidates to join.
✕Less likely to help
People without diabetes, without foot wounds, or those unable to attend participating clinical sites are unlikely to benefit directly from this program.
What this research studies
If you have diabetes and a foot ulcer, this clinical unit works to collect samples and test simple markers that might show if a wound is infected or not healing. The team runs a master protocol with smaller substudies to finalize and standardize these biomarker tests and how they would be used in clinic visits. The project links clinics, lab testing, and data analysis so results can be used at the point of care rather than waiting for long lab turnaround. The goal is to move promising tests from early work into real-world use across participating sites.
Why it matters
Potential benefit: Successful point-of-care biomarkers could lead to earlier problem detection, more targeted treatments, and fewer amputations for people with diabetic foot ulcers.
How similar studies have gone: Earlier pilot work and the first cycle of the Diabetic Foot Consortium showed promising biomarker leads, but larger validation and implementation are still needed.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Holmes, Crystal Murray — University of Michigan at Ann Arbor
- Study coordinator: Holmes, Crystal Murray
Related research
Other NIH-funded projects on the same topics.
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Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design
A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.
-
Home-based exercise to help Veterans recover after healed diabetic foot ulcers
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How Medicaid Coverage Changes Diabetic Foot Care in Safety-Net Patients
This project looks at how new Medicaid coverage in California affects foot care, ED visits, and outcomes for adults with diabetes in safety-net populations.
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Multi-targeted approach to help heal diabetic foot ulcers using electric fields and nitric oxide
A study to test a combo treatment using electric field stimulation and nitric oxide to boost healing in diabetic foot ulcers.
-
Wound fluid test to predict healing in diabetic foot ulcers
This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.
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MTX-001 for healing diabetic foot ulcers in people with diabetes
A first–in–class biologic therapy called MTX-001 is being tested to help heal diabetic foot ulcers and reduce infection risk in adults with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.