Investigating diabetic foot ulcers and their treatment
Official title: NIDDK Diabetic Foot Consortium Clinical Research Unit
Funded at University of Michigan at Ann Arbor · NIH-11012847 · Data updated 2026-11-12
This study is looking for ways to help people with diabetes catch and manage foot ulcers early, so they can avoid serious health problems, and it invites patients to participate in different parts of the research to improve treatment options.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 15, 2018 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $727,080 |
| NIH project number | 5U01DK119083-08 |
| Project ID | NIH-11012847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic foot ulcers.
✕Less likely to help
Patients without diabetes or those who do not have any risk factors for diabetic foot ulcers may not benefit from this research.
What this research studies
This research focuses on diabetic foot ulcers (DFUs), a common complication for individuals with diabetes that can lead to severe health issues, including amputations. The project aims to validate and implement biomarkers that can help in the early detection and management of DFUs at the point of care. By leveraging a collaborative clinical and translational research team, the study will expand on previous work to improve treatment protocols and patient outcomes. Patients may be involved in various substudies aimed at enhancing the understanding and management of DFUs.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of amputations and improve the quality of life for patients with diabetes.
How similar studies have gone: Previous research has shown promise in using biomarkers for the management of diabetic foot ulcers, indicating that this approach could lead to meaningful advancements.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Holmes, Crystal Murray — University of Michigan at Ann Arbor
- Study coordinator: Holmes, Crystal Murray
Related research
Other NIH-funded projects on the same topics.
-
Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design
A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.
-
Home-based exercise to help Veterans recover after healed diabetic foot ulcers
A home-based exercise program for Veterans who recently healed from a diabetic foot ulcer to improve walking and daily function.
-
How Medicaid Coverage Changes Diabetic Foot Care in Safety-Net Patients
This project looks at how new Medicaid coverage in California affects foot care, ED visits, and outcomes for adults with diabetes in safety-net populations.
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Multi-targeted approach to help heal diabetic foot ulcers using electric fields and nitric oxide
A study to test a combo treatment using electric field stimulation and nitric oxide to boost healing in diabetic foot ulcers.
-
Wound fluid test to predict healing in diabetic foot ulcers
This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.
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MTX-001 for healing diabetic foot ulcers in people with diabetes
A first–in–class biologic therapy called MTX-001 is being tested to help heal diabetic foot ulcers and reduce infection risk in adults with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.