Condition

Foot Ulcer clinical trials and research

• 12Clinical trials
• 13NIH research projects
• 4Countries

Newest Foot Ulcer clinical trials

All recruiting trials (12)

• Transcutaneous and topical photobiomodulation for diabetic foot ulcers

  This phase 2 trial tests whether combining transcutaneous and topical photobiomodulation helps heal foot ulcers in adults with diabetes.

  Recruiting Phase 2 University of Nove de Julho · Teresina, Piauí · NCT07798960

• Photoacoustic and multispectral imaging to monitor foot wounds after surgery

  This pilot will test whether photoacoustic and multispectral imaging can monitor blood flow and help guide care for adults with chronic foot ulcers from poor arterial circulation.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT07216599

• Single-layer placental graft plus standard care for stubborn diabetic foot ulcers

  This trial will try a single-layer placental-based graft together with usual wound care for adults whose diabetic foot ulcers did not heal after standard treatment in an earlier trial.

  Recruiting Phase 4 Applied Biologics, LLC · Hollywood, Florida · NCT07159282

• Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers

  This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.

  Recruiting C5 Biomedical · Metairie, Louisiana · NCT06674980

• Evaluating a new placental-based treatment for diabetic foot ulcers

  This study is testing if a new placental treatment can help adults with hard-to-heal diabetic foot ulcers get better faster when used alongside regular care.

  Recruiting Applied Biologics, LLC · Clinton Township, Michigan · NCT06564831

• Using dehydrated human amnion membrane to treat nonhealing diabetic foot ulcers

  This study is testing if adding dehydrated human amnion membrane to regular care can help people with stubborn diabetic foot ulcers heal better.

  Recruiting Axolotl Biologix · Thousand Oaks, California · NCT06550596

• Evaluating new treatments for hard-to-heal diabetic foot ulcers

  This study is testing if new treatments using special placental products can help heal tough diabetic foot ulcers better than the usual care alone.

  Recruiting at 3 sites StimLabs · Omaha, Nebraska and 4 other locations · NCT06449638

• Evaluating ENERGI-F703 GEL for diabetic foot ulcers

  This study is testing if a new gel can help heal diabetic foot ulcers that haven't improved for at least four weeks.

  Recruiting at 24 sites Phase 3 Energenesis Biomedical Co., Ltd. · Miami, Florida and 23 other locations · NCT05930210

• Using stem cells from fat to treat diabetic foot ulcers

  This study is testing if using stem cells from fat, along with a special blood product, can help heal chronic foot ulcers in people with diabetes.

  Recruiting Phase 1 University of the Punjab · Lahore, Punjab Province · NCT05610865

• Impact of Removable Cast Walker Design on Usability for DFU Patients

  This study tests whether different removable cast walker designs improve how easy they are to use and whether that helps DFU healing in people with diabetes.

  Recruiting Rosalind Franklin University of Medicine and Science · North Chicago, Illinois · NCT05415878

• Using a special cast to heal diabetic foot ulcers

  This study tests whether a special soft cast can help heal diabetic foot ulcers better than regular methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04210089

• Imaging techniques for diabetic foot ulcers

  This study is testing different ways to take pictures and measure diabetic foot ulcers to see which method works best for capturing their size.

  Recruiting University of Iowa · Iowa City, Iowa · NCT03942081

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design

  A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11640036

• Home-based exercise to help Veterans recover after healed diabetic foot ulcers

  A home-based exercise program for Veterans who recently healed from a diabetic foot ulcer to improve walking and daily function.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511696

• Wound fluid test to predict healing in diabetic foot ulcers

  This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11323031

• Identifying biomarkers in wound fluid for diabetic foot ulcers

  This study is looking at special substances in the fluid from diabetic foot ulcers to see if they can help doctors predict how well the wounds will heal, which could lead to better and more personalized treatments for people with these types of wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11309403

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it's creating a special test to help doctors understand how well these wounds are healing so they can provide better, personalized care for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11166816

• Home exercise program to help Veterans recover after a recently healed diabetic foot ulcer

  A home-based exercise program designed to help Veterans who recently healed from a diabetic foot ulcer regain strength, mobility, and independence.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11132619

• Understanding Diabetic Foot Ulcer Healing

  This project aims to find a way to predict how well diabetic foot ulcers will heal by looking at specific markers related to inflammation.

  NIH research Drexel University · Philadelphia, United States · NIH-11121939

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it aims to find specific genes that can help predict how well these wounds will heal, so that doctors can better manage treatment for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11090049

• Improving treatment for diabetic foot ulcers with a new hydrogel

  This study is testing a new gel that helps heal diabetic foot ulcers by slowly releasing a special growth factor, making it easier for people with diabetes to recover without needing to change their dressings as often.

  NIH research Gelsana Therapeutics, INC. · Aurora, United States · NIH-11007010

• Home-based exercise to help Veterans recover from diabetic foot ulcers

  This study is looking to help Veterans who have recently healed from diabetic foot ulcers get stronger and move better at home through a personalized exercise program, making it easier for them to stay healthy and avoid future problems.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-10923447

• Understanding infections in diabetic foot ulcers and their recurrence

  This study is looking at how infections in diabetic foot ulcers can come back and cause serious problems, like amputations, and it aims to find better ways to detect and treat these infections for people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10854979

• Improving the design of removable cast walkers for diabetic foot ulcers

  This study is looking at how to make removable cast walkers easier to use for people with diabetic foot ulcers, so they can wear them more often and help their feet heal better.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-10843854

• Comparing continuous glucose monitoring to finger stick testing for healing diabetic foot ulcers.

  This study is looking at whether using a continuous glucose monitor (CGM) helps people with diabetic foot ulcers heal better after leaving the hospital compared to the usual finger stick testing, and it’s for patients who have just been treated for these ulcers.

  NIH research Emory University · Atlanta, United States · NIH-10727731

Related topics

Quick answers

How many Foot Ulcer clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (10 trials), Taiwan (1 trial), Brazil (1 trial), Pakistan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 3: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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