New treatment for diabetic foot ulcers using nanoparticles and microRNA
Official title: A Novel Anti-inflammatoryand Anti-oxidant Therapy for Treating Non-healing Diabetic Foot Ulcers
Funded at Ceria Therapeutics, INC. · NIH-11011333 · Data updated 2026-11-12
This study is testing a new treatment to help heal diabetic foot ulcers faster by using a special injection that targets inflammation and stress in the body, and it's designed for people with diabetes who are dealing with these painful wounds.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ceria Therapeutics, INC. NIH-funded |
| Lab location | 1 site (Tucson, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,034,376 |
| NIH project number | 5R44DK136463-02 |
| Project ID | NIH-11011333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with non-healing diabetic foot ulcers.
✕Less likely to help
Patients who do not have diabetic foot ulcers or those with other unrelated chronic wounds may not benefit from this research.
What this research studies
This research focuses on developing a novel therapy to improve healing in diabetic foot ulcers, which are a common and serious complication of diabetes. The approach involves using cerium oxide nanoparticles combined with a microRNA mimic that targets inflammation and oxidative stress, both of which hinder wound healing. The treatment is administered through a single intradermal injection, aiming to reduce inflammation and promote faster healing of the ulcers. Patients will be monitored for improvements in wound healing and overall recovery.
Why it matters
Potential benefit: If successful, this research could significantly enhance the healing process for diabetic foot ulcers, potentially reducing the need for amputations.
How similar studies have gone: Other research has shown promise in using nanoparticles and microRNA therapies for wound healing, indicating a potential for success with this novel approach.
Where this research is happening
-
Ceria Therapeutics, INC.
Tucson, United States Active
Researchers
- Principal investigator: Jackson, David — Ceria Therapeutics, INC.
- Study coordinator: Jackson, David
Related research
Other NIH-funded projects on the same topics.
-
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-
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-
How Medicaid Coverage Changes Diabetic Foot Care in Safety-Net Patients
This project looks at how new Medicaid coverage in California affects foot care, ED visits, and outcomes for adults with diabetes in safety-net populations.
-
Multi-targeted approach to help heal diabetic foot ulcers using electric fields and nitric oxide
A study to test a combo treatment using electric field stimulation and nitric oxide to boost healing in diabetic foot ulcers.
-
Wound fluid test to predict healing in diabetic foot ulcers
This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.
-
MTX-001 for healing diabetic foot ulcers in people with diabetes
A first–in–class biologic therapy called MTX-001 is being tested to help heal diabetic foot ulcers and reduce infection risk in adults with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.