Using modified mRNA to improve healing of diabetic foot ulcers
Use of Modified mRNA for the Treatment of Diabetic Foot Ulceration
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11077275
This study is looking at how special bandages that use modified mRNA can help heal diabetic foot ulcers better, making it easier for people with diabetes to recover from these tough wounds.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11077275 on ClinicalTrials.gov |
What this research studies
This research investigates how modified mRNA can be used to enhance the healing process of diabetic foot ulcers, a common and serious complication for individuals with diabetes. By analyzing the molecular characteristics of healing and non-healing ulcers, the study aims to identify key factors that promote wound healing. The researchers are developing specialized alginate bandages that can deliver these modified mRNAs directly to the wound site, potentially improving healing outcomes. The approach involves a combination of different mRNAs delivered in a specific sequence to mimic natural healing processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing foot ulcers and have not responded well to standard treatments.
Not a fit: Patients with foot ulcers not related to diabetes or those who have other underlying conditions affecting wound healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for diabetic foot ulcers, reducing the risk of complications such as infections and amputations.
How similar studies have performed: Other research has shown promise in using mRNA therapies for wound healing, indicating that this approach could be a viable and innovative treatment option.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VEVES, ARISTIDIS — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: VEVES, ARISTIDIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.