Using modified mRNA to improve healing of diabetic foot ulcers
Official title: Use of Modified mRNA for the Treatment of Diabetic Foot Ulceration
Funded at Beth Israel Deaconess Medical Center · NIH-11077275 · Data updated 2026-11-12
This study is looking at how special bandages that use modified mRNA can help heal diabetic foot ulcers better, making it easier for people with diabetes to recover from these tough wounds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 19, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $734,549 |
| NIH project number | 5R01DK136699-02 |
| Project ID | NIH-11077275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are experiencing foot ulcers and have not responded well to standard treatments.
✕Less likely to help
Patients with foot ulcers not related to diabetes or those who have other underlying conditions affecting wound healing may not benefit from this research.
What this research studies
This research investigates how modified mRNA can be used to enhance the healing process of diabetic foot ulcers, a common and serious complication for individuals with diabetes. By analyzing the molecular characteristics of healing and non-healing ulcers, the study aims to identify key factors that promote wound healing. The researchers are developing specialized alginate bandages that can deliver these modified mRNAs directly to the wound site, potentially improving healing outcomes. The approach involves a combination of different mRNAs delivered in a specific sequence to mimic natural healing processes.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for diabetic foot ulcers, reducing the risk of complications such as infections and amputations.
How similar studies have gone: Other research has shown promise in using mRNA therapies for wound healing, indicating that this approach could be a viable and innovative treatment option.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Veves, Aristidis — Beth Israel Deaconess Medical Center
- Study coordinator: Veves, Aristidis
Related research
Other NIH-funded projects on the same topics.
-
Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design
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-
Home-based exercise to help Veterans recover after healed diabetic foot ulcers
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-
How Medicaid Coverage Changes Diabetic Foot Care in Safety-Net Patients
This project looks at how new Medicaid coverage in California affects foot care, ED visits, and outcomes for adults with diabetes in safety-net populations.
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Multi-targeted approach to help heal diabetic foot ulcers using electric fields and nitric oxide
A study to test a combo treatment using electric field stimulation and nitric oxide to boost healing in diabetic foot ulcers.
-
Wound fluid test to predict healing in diabetic foot ulcers
This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.
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MTX-001 for healing diabetic foot ulcers in people with diabetes
A first–in–class biologic therapy called MTX-001 is being tested to help heal diabetic foot ulcers and reduce infection risk in adults with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.