Condition

Ulcer clinical trials and research

• 11Clinical trials
• 34NIH research projects
• 2Countries

Newest Ulcer clinical trials

All recruiting trials (11)

• Coordinated primary-care MDT approach for hard-to-heal ulcers

  A group of adults with hard-to-heal diabetic foot ulcers will be randomly assigned to standard care or a coordinated multidisciplinary team to see if the team approach helps ulcers heal better.

  Recruiting Nordsjaellands Hospital · Hillerød · NCT07747896

• Human placental membrane products plus standard care for nonhealing diabetic foot and venous leg ulcers

  This trial will try human placental membrane products together with standard wound care to help adults whose diabetic foot ulcers or venous leg ulcers have not healed.

  Recruiting BioLab Holdings · Philidelphia, Pennsylvania · NCT07364630

• How long healed diabetic foot ulcers stay closed after CAMPX treatment

  This follow-up tests whether diabetic foot ulcers that fully closed by 12 weeks in the CAMPX trial stay closed over a year using home photographic and thermal scans with the BlueDrop OneStep Foot Scanner.

  Recruiting Applied Biologics, LLC · Clinton Township, Michigan · NCT07360418

• Using human placental membrane wraps with regular wound care to help heal stubborn diabetic foot and venous leg ulcers

  This trial tests whether adding one of four human placental membrane wraps to standard wound care helps people with nonhealing diabetic foot or venous leg ulcers heal faster and more completely than standard care alone.

  Recruiting Phase 4 BioLab Holdings · Philidelphia, Pennsylvania · NCT07089602

• Wound matrix treatments for nonhealing diabetic foot ulcers

  This trial will test whether adding special wound matrix products to standard care helps close hard-to-heal diabetic foot ulcers in adults with type 1 or 2 diabetes within 12 weeks.

  Recruiting Phase 4 Sequence LifeScience, Inc. · Monroeville, Pennsylvania · NCT07086443

• Cellular, acellular, and matrix wound products plus standard care for nonhealing stage 3–4 pressure ulcers

  This study will try several cellular, acellular, and matrix-like wound products with standard care to see if adults with nonhealing stage 3–4 pressure ulcers heal more completely over 20 weeks than with standard care alone.

  Recruiting Phase 4 Tiger Biosciences, LLC. · Monroeville, Pennsylvania · NCT06999590

• Evaluating new treatments for nonhealing diabetic foot and venous leg ulcers.

  This study is testing whether new treatments for stubborn diabetic foot and leg ulcers can help people heal better when combined with standard care compared to just standard care alone.

  Recruiting Phase 4 Tiger Biosciences, LLC. · Monroeville, Pennsylvania · NCT06826339

• Evaluating Onyx™ Liquid Embolic System for treating active arterial bleeding

  This study is testing whether the Onyx™ Liquid Embolic System can safely and effectively stop active bleeding in patients with peripheral artery issues.

  Recruiting at 20 sites Medtronic Endovascular · Phoenix, Arizona and 19 other locations · NCT06742801

• Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers

  This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.

  Recruiting C5 Biomedical · Metairie, Louisiana · NCT06674980

• Treatment of marginal ulcers using low-thermal argon plasma

  This study is testing if a new low-thermal argon plasma treatment can help heal stubborn ulcers that some people get after weight loss surgery, to see if it works better than the usual medicine.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06543316

• Using a special cast to heal diabetic foot ulcers

  This study tests whether a special soft cast can help heal diabetic foot ulcers better than regular methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04210089

NIH-funded research (34)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design

  A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11640036

• Parasitic Keratitis: Do Steroid Eyedrops Help or Harm?

  A randomized trial will test whether adding a low-dose corticosteroid eyedrops after standard anti-amoebic therapy improves vision for people with Acanthamoeba keratitis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11532328

• Topical corticosteroids for acanthamoeba keratitis in adults

  A randomized trial tests whether adding a mild steroid drop after standard anti-amoebic therapy helps improve vision and inflammation in people with acanthamoeba keratitis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11532327

• Corticosteroids for Acanthamoeba Keratitis in adults

  A randomized trial tests whether adding a corticosteroid eye drop after standard anti-amoebic therapy helps improve vision in people with acanthamoeba keratitis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11532326

• Home-based exercise to help Veterans recover after healed diabetic foot ulcers

  A home-based exercise program for Veterans who recently healed from a diabetic foot ulcer to improve walking and daily function.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511696

• Wearable insoles to help prevent diabetic foot ulcers

  A wearable insole device will monitor foot pressure and temperature in adults with diabetes to help prevent foot ulcers and potential amputations.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11413433

• Automated Ulcer Analysis to Quickly ID Eye Infections

  A clinician-facing tool will use a fast, low-cost algorithm to identify the type of organism causing microbial keratitis to guide treatment at first presentation.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11394832

• Breathable, moisture-balancing dressing for ischemic leg ulcers

  A new breathable wound dressing aims to help people with ischemic PAD ulcers heal faster and avoid infection.

  NIH research University of Nebraska Omaha · Omaha, United States · NIH-11333257

• Wound fluid test to predict healing in diabetic foot ulcers

  This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11323031

• Identifying biomarkers in wound fluid for diabetic foot ulcers

  This study is looking at special substances in the fluid from diabetic foot ulcers to see if they can help doctors predict how well the wounds will heal, which could lead to better and more personalized treatments for people with these types of wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11309403

• Topical steroid trial for acanthamoeba keratitis

  A personalized trial will test whether adding a low-dose corticosteroid eyedrop after standard anti-amoebic treatment helps improve vision for people with acanthamoeba keratitis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11308673

• Quick tool to identify what germ is causing a corneal ulcer

  This project is building an easy-to-use tool that looks at corneal ulcers to quickly tell doctors whether bacteria, fungi, or other organisms are causing the infection for people with painful corneal infections.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11197618

• How Stomach Cells Adapt to Heal Gastric Ulcers

  This project explores how specific stomach cells change and adapt to help repair gastric ulcers, which are sores in the stomach lining.

  NIH research Yale University · New Haven, United States · NIH-11184216

• Rapid point-of-care test for syphilis and other genital ulcer infections

  A small, portable molecular test to quickly detect syphilis (and other causes of genital ulcers) for adults in clinic settings.

  NIH research Magic Lifescience, INC. · Mountain View, United States · NIH-11174434

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it's creating a special test to help doctors understand how well these wounds are healing so they can provide better, personalized care for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11166816

• Why mouth wounds heal slowly in people with diabetes

  This project looks at how diabetes changes the stem cells that repair the mouth lining to find ways to help adults with diabetes heal oral wounds faster.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11146431

• Home exercise program to help Veterans recover after a recently healed diabetic foot ulcer

  A home-based exercise program designed to help Veterans who recently healed from a diabetic foot ulcer regain strength, mobility, and independence.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11132619

• Understanding Diabetic Foot Ulcer Healing

  This project aims to find a way to predict how well diabetic foot ulcers will heal by looking at specific markers related to inflammation.

  NIH research Drexel University · Philadelphia, United States · NIH-11121939

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it aims to find specific genes that can help predict how well these wounds will heal, so that doctors can better manage treatment for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11090049

• Improving outcomes for corneal ulcers by detecting pathogens and antibiotic resistance

  This study is looking at infections in the eye that can cause serious vision problems, and it's for anyone who wants to help improve how these infections are diagnosed and treated by tracking the germs that cause them and how they respond to antibiotics in different places and times of the year.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11088773

• Investigating the use of corticosteroids for treating a blinding eye infection.

  This study is looking at whether corticosteroid eye drops can help people with Acanthamoeba keratitis, a serious eye infection that can cause blindness, by comparing them to a placebo in 200 patients who haven't fully healed after standard treatment.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11074549

• How a new wound dressing helps heal difficult ulcers

  This study is testing a new type of wound dressing that helps heal painful ulcers on the legs caused by poor blood flow, specifically for people with peripheral artery disease, by keeping the wound moist and protected from infection.

  NIH research University of Nebraska Omaha · Omaha, United States · NIH-11035253

• Improving treatment for diabetic foot ulcers with a new hydrogel

  This study is testing a new gel that helps heal diabetic foot ulcers by slowly releasing a special growth factor, making it easier for people with diabetes to recover without needing to change their dressings as often.

  NIH research Gelsana Therapeutics, INC. · Aurora, United States · NIH-11007010

• Using special peptides to speed up healing of pressure ulcers

  This study is testing a special gel that helps heal bed sores by improving blood flow and tissue repair, and it's being tried out on older diabetic mice to see how well it works compared to a current approved treatment.

  NIH research Adepthera, LLC · Palo Alto, United States · NIH-11006211

• Investigating how certain stomach cells change in response to gastric ulcers

  This study is looking at how certain stomach cells change during the healing of gastric ulcers, which can happen more often because of things like pain relievers and infections, and it hopes to find new ways to help people heal better from these ulcers.

  NIH research Yale University · New Haven, United States · NIH-10987605

• Creating a new test for quickly diagnosing syphilis at the clinic

  This study is working on a quick and easy test for syphilis that can be done right in the doctor's office, so patients can get their results and treatment faster, without needing special lab equipment.

  NIH research Magic Lifescience, INC. · Mountain View, United States · NIH-10978102

• Home-based exercise to help Veterans recover from diabetic foot ulcers

  This study is looking to help Veterans who have recently healed from diabetic foot ulcers get stronger and move better at home through a personalized exercise program, making it easier for them to stay healthy and avoid future problems.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-10923447

• Understanding how diabetes affects healing in the mouth

  This study looks at how diabetes affects the healing of mouth wounds, especially for people getting dental work, and it aims to find new ways to help these wounds heal better by understanding the role of special stem cells in the mouth.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10886222

• Understanding infections in diabetic foot ulcers and their recurrence

  This study is looking at how infections in diabetic foot ulcers can come back and cause serious problems, like amputations, and it aims to find better ways to detect and treat these infections for people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10854979

• Improving the design of removable cast walkers for diabetic foot ulcers

  This study is looking at how to make removable cast walkers easier to use for people with diabetic foot ulcers, so they can wear them more often and help their feet heal better.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-10843854

• Investigating how mitochondrial function affects ulcer healing in inflammatory bowel disease.

  This study is looking at how the energy factories in your cells, called mitochondria, might affect the healing of ulcers in people with inflammatory bowel disease (IBD), and it hopes to find better ways to help you heal.

  NIH research University of Kentucky · Lexington, United States · NIH-10781979

• A new device for quickly diagnosing corneal ulcers

  This study is testing a new portable device that helps doctors quickly and accurately find out what’s causing corneal ulcers, which can lead to blindness if not treated right away, making it easier for patients to get the right care.

  NIH research University of Arizona · Tucson, United States · NIH-10761733

• Comparing continuous glucose monitoring to finger stick testing for healing diabetic foot ulcers.

  This study is looking at whether using a continuous glucose monitor (CGM) helps people with diabetic foot ulcers heal better after leaving the hospital compared to the usual finger stick testing, and it’s for patients who have just been treated for these ulcers.

  NIH research Emory University · Atlanta, United States · NIH-10727731

• Using steroids and cross-linking to treat corneal ulcers

  This study is looking at whether using steroids along with a special eye treatment can help people with serious vision loss from bacterial corneal ulcers heal better and see more clearly.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10666415

Related topics

Quick answers

How many Ulcer clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (10 trials), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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