Understanding why diabetic foot and venous leg ulcers heal poorly
Official title: Core mechanisms that contribute to inhibition of wound healing in diabetic foot and venous leg ulcers
Funded at University of Miami School of Medicine · NIH-11093569 · Data updated 2026-11-12
This study is looking at why diabetic foot ulcers and venous leg ulcers don’t heal well, by examining tissue samples to find out how certain genes and the bacteria on our skin might affect healing, with the hope of creating better treatments for these stubborn wounds.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $57,538 |
| NIH project number | 5F30DK132806-04 |
| Project ID | NIH-11093569 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from diabetic foot ulcers or venous leg ulcers.
✕Less likely to help
Patients with acute wounds or those not suffering from chronic ulcers may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms that prevent diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) from healing effectively. By analyzing human tissue samples, the team aims to identify specific molecular pathways that contribute to the chronic non-healing nature of these wounds. The study utilizes advanced techniques such as RNA sequencing and bioinformatics to uncover a unique gene signature associated with these ulcers. The goal is to better understand how the microbiome influences wound healing and to develop more effective treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic wounds, enhancing healing and quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding chronic wound healing mechanisms, but this specific approach is novel and aims to fill existing gaps in knowledge.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Burgess, Jamie Lee — University of Miami School of Medicine
- Study coordinator: Burgess, Jamie Lee
Related research
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Understanding how healing tissue uses tiny messengers and scaffolds to repair wounds
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.