Condition

Diabetic Foot Ulcer clinical trials and research

• 53Clinical trials
• 13NIH research projects
• 18Countries

Newest Diabetic Foot Ulcer clinical trials

All recruiting trials (53)

• BIOxHEAL plus standard care for nonhealing diabetic foot ulcers

  A multicenter study tests whether applying BIOxHEAL, a placental-derived biologic, to stubborn diabetic foot ulcers helps more people heal when added to standard wound care.

  Recruiting Phase 3 Applied Biologics, LLC · Boardman, Ohio · NCT07852338

• Calcaneal Bone Marrow Cells in Foot/Ankle Surgery Patients

  This observational study tests whether routine preoperative blood tests relate to the quality and behavior of mesenchymal stem cells from calcaneal bone marrow in adults undergoing foot or ankle surgery.

  Recruiting Universidade Sao Francisco · Bragança Paulista, São Paulo · NCT07802106

• L-Carnitine as an add-on for healing diabetic foot ulcers

  This study tests whether taking L-Carnitine helps wound healing in adults with diabetic foot ulcers, alongside standard diabetes and wound care.

  Recruiting Phase 2 Ain Shams University · Cairo, Cairo Governorate and 1 other locations · NCT07768228

• THERAVEX Tissue Care Spray Plus for Healing of Skin Wounds and Ulcers

  This observational review tests whether THERAVEX Tissue Care Spray Plus, used with standard wound care, helps heal various skin wounds and chronic ulcers in adults.

  Recruiting Biointelligent Technology Systems SL · Barcelona · NCT07617961

• Pulsating electromagnetic field therapy for diabetic foot ulcers

  This trial tests whether a PEMF device called CRAD ULCER X-01 helps heal chronic diabetic foot ulcers when added to standard wound care.

  Recruiting National Defence University of Malaysia · Kuala Lumpur · NCT07465640

• Transverse tibial bone transport to help heal chronic diabetic foot ulcers

  This study tests a surgical approach called transverse tibial bone transport to see if it can help heal long‑lasting diabetic foot ulcers and prevent limb loss in adults with limited treatment options.

  Recruiting Biodynamik, Inc · Jacksonville, Florida · NCT07444593

• ELU42 topical spray for chronic Wagner 1–2 diabetic foot ulcers

  This will test whether ELU42 topical spray can help heal chronic Wagner 1–2 diabetic foot ulcers in adults.

  Recruiting at 4 sites Phase 1/2 Eluciderm Inc · O'Fallon, Illinois and 3 other locations · NCT07396376

• Human placental membrane products plus standard care for nonhealing diabetic foot and venous leg ulcers

  This trial will try human placental membrane products together with standard wound care to help adults whose diabetic foot ulcers or venous leg ulcers have not healed.

  Recruiting BioLab Holdings · Philidelphia, Pennsylvania · NCT07364630

• How long healed diabetic foot ulcers stay closed after CAMPX treatment

  This follow-up tests whether diabetic foot ulcers that fully closed by 12 weeks in the CAMPX trial stay closed over a year using home photographic and thermal scans with the BlueDrop OneStep Foot Scanner.

  Recruiting Applied Biologics, LLC · Clinton Township, Michigan · NCT07360418

• FeetSee thermal images for people with diabetes who have healed plantar ulcers

  This study tests if using a FeetSee thermal camera with a smartphone can help people with diabetes who had a healed plantar ulcer catch early signs of trouble at the bottom of the feet.

  Recruiting at 2 sites Diabetis JSC · Vilnius and 3 other locations · NCT07300163

• Intermittent negative pressure therapy for diabetic foot ulcers (INPRESS)

  This study will test whether using the FlowOx device for one hour in the morning and one hour in the evening for 12 weeks can raise toe blood pressure and reduce wound size in adults with diabetic foot ulcers.

  Recruiting Woodlands Hospital · Singapore · NCT07291817

• Comprehensive assistance and navigation for diabetic foot ulcers

  This program tests whether weekly support from a patient navigator helps people hospitalized with diabetic foot ulcers heal their wounds within 20 weeks.

  Recruiting Emory University · Atlanta, Georgia · NCT07223268

• Factors linked to diabetic foot ulcer severity and outcomes

  This project looks at records of about 200 people with diabetic foot ulcers treated at 5 Azar Hospital in 2024 to see if blood tests and other health factors link to worse ulcers.

  Recruiting Golestan University of Medical sciences · Gorgan, Outside of the US · NCT07188337

• Omeza Complete Matrix to help heal diabetic foot ulcers

  This test will see if adding OCM (Omeza Complete Matrix) to standard wound care helps adults with diabetic foot ulcers heal completely.

  Recruiting at 10 sites Omeza, LLC · Evergreen Park, Illinois and 9 other locations · NCT07161830

• Single-layer placental graft plus standard care for stubborn diabetic foot ulcers

  This trial will try a single-layer placental-based graft together with usual wound care for adults whose diabetic foot ulcers did not heal after standard treatment in an earlier trial.

  Recruiting Phase 4 Applied Biologics, LLC · Hollywood, Florida · NCT07159282

• Custom insoles and TENS for healing and pain relief in diabetic foot ulcers

  This project will test whether adding transcutaneous electrical nerve stimulation (TENS) and/or a custom insole to usual care helps heal and reduce pain from Grade 1–2 diabetic foot ulcers in adults with diabetes.

  Recruiting University of Lahore · Lahore, Punjab Province · NCT07109895

• Using human placental membrane wraps with regular wound care to help heal stubborn diabetic foot and venous leg ulcers

  This trial tests whether adding one of four human placental membrane wraps to standard wound care helps people with nonhealing diabetic foot or venous leg ulcers heal faster and more completely than standard care alone.

  Recruiting Phase 4 BioLab Holdings · Philidelphia, Pennsylvania · NCT07089602

• Wound matrix treatments for nonhealing diabetic foot ulcers

  This trial will test whether adding special wound matrix products to standard care helps close hard-to-heal diabetic foot ulcers in adults with type 1 or 2 diabetes within 12 weeks.

  Recruiting Phase 4 Sequence LifeScience, Inc. · Monroeville, Pennsylvania · NCT07086443

• NeoThelium FT with standard wound care for diabetic foot ulcers

  This trial will test whether adding NeoThelium FT to standard wound care helps adults with chronic diabetic foot ulcers heal faster than standard care alone.

  Recruiting at 4 sites NuScience Medical Biologics, LLC · Alexandria, Louisiana and 7 other locations · NCT06938685

• Comparing exercise types during treatment of diabetic foot ulcers

  This study is testing whether two types of exercise can help people with diabetic foot ulcers recover better than just standard care.

  Recruiting Al Hayah University In Cairo · Cairo · NCT06916663

• Evaluating a new gel treatment for diabetic foot ulcers

  This study is testing a new gel treatment for diabetic foot ulcers to see if it helps heal the wounds better than the usual care.

  Recruiting Phase 2 Zhuhai Rui-Inno Pharmaceutical Technology Co., Ltd. · Durham, North Carolina · NCT06852976

• Live stem cells from fat tissue to heal diabetic foot ulcers

  A randomized study tests whether two doses of live allogeneic adipose-derived stem cells can safely help heal diabetic foot ulcers.

  Recruiting Phase 2 Medical University of Warsaw · Warsaw · NCT06843122

• Using Negative Pressure Wound Therapy for Healing Diabetic Foot Wounds

  This study tests if using Negative Pressure Wound Therapy along with skin substitutes can help heal diabetic foot wounds better for people who have had toe amputations.

  Recruiting at 2 sites Singapore General Hospital · Singapore and 1 other locations · NCT06832787

• Evaluating new treatments for nonhealing diabetic foot and venous leg ulcers.

  This study is testing whether new treatments for stubborn diabetic foot and leg ulcers can help people heal better when combined with standard care compared to just standard care alone.

  Recruiting Phase 4 Tiger Biosciences, LLC. · Monroeville, Pennsylvania · NCT06826339

• Tropocells autologous platelet-rich fibrin for healing mild-to-moderate neuroischemic diabetic foot ulcers

  This will test whether Tropocells autologous platelet-rich fibrin (PRF) helps close mild-to-moderate neuroischemic diabetic foot ulcers in adults with type 1 or type 2 diabetes.

  Recruiting at 2 sites Phase 2 Estar Medical dba Medical Technologies, LTD · Corpus Christi, Texas and 1 other locations · NCT06810726

• Comparing Negative Pressure Wound Therapy to Standard Care for Diabetic Foot Ulcers

  This study is testing if a special wound treatment called Negative Pressure Wound Therapy works better than standard care for healing diabetic foot ulcers.

  Recruiting University Hospital, Akershus · Oslo, Nordbyhagen and 1 other locations · NCT06721754

• Evaluating a new collagen treatment for diabetic foot ulcers

  This study is testing a new collagen treatment for diabetic foot ulcers to see if it helps heal wounds better than standard care alone.

  Recruiting Organogenesis · Clevland, Ohio · NCT06618612

• Evaluating a new placental-based treatment for diabetic foot ulcers

  This study is testing if a new placental treatment can help adults with hard-to-heal diabetic foot ulcers get better faster when used alongside regular care.

  Recruiting Applied Biologics, LLC · Clinton Township, Michigan · NCT06564831

• Evaluating new treatments for diabetic foot and venous leg ulcers

  This study is testing different new treatments for stubborn diabetic foot and leg ulcers to see if they help heal better than the standard care alone.

  Recruiting Stability Biologics · Circleville, Ohio · NCT06560502

• Using dehydrated human amnion membrane to treat nonhealing diabetic foot ulcers

  This study is testing if adding dehydrated human amnion membrane to regular care can help people with stubborn diabetic foot ulcers heal better.

  Recruiting Axolotl Biologix · Thousand Oaks, California · NCT06550596

• Comparing PelloGraft and SanoGraft for treating diabetic foot and venous leg ulcers

  This study is testing whether PelloGraft can help heal diabetic foot ulcers and SanoGraft can help heal venous leg ulcers better than standard care.

  Recruiting at 2 sites Surgenex · Vista, California and 1 other locations · NCT06515093

• Lifestyle intervention to prevent diabetic foot ulcers from coming back

  This study tests a lifestyle program to help people who have healed diabetic foot ulcers take better care of their feet and manage their diabetes to prevent the ulcers from coming back.

  Recruiting at 2 sites University of Southern California · Downey, California and 2 other locations · NCT06487780

• Using perinatal tissue allografts to heal diabetic foot ulcers

  This study is testing if adding special tissue from newborns to regular care can help heal diabetic foot ulcers faster and better than just using standard care alone.

  Recruiting Samaritan Biologics · Monroe, North Carolina · NCT06437028

• Topical BB-101 for treating diabetic foot ulcers

  This study is testing a new cream called BB-101 to see if it can help heal foot ulcers in people with diabetes better than a placebo.

  Recruiting at 4 sites Phase 2 Blue Blood Biotech Corp. · Tainan and 4 other locations · NCT06383013

• Tailored lifestyle intervention for diabetic foot ulcer care

  This study is testing a new online program led by occupational therapists to help people with diabetic foot ulcers better manage their care and follow treatment plans over 8 weeks.

  Recruiting University of Southern California · Los Angeles, California · NCT06278935

• Observing the use of amnion/chorion membrane for chronic wounds

  This study is testing if a new treatment using a special membrane can help people with stubborn diabetic foot ulcers and venous leg ulcers heal better than with standard care.

  Recruiting at 5 sites MiMedx Group, Inc. · Kobe, Hyōgo and 4 other locations · NCT06236750

• Follow-up evaluation of ALLO-ASC-DFU treatment for diabetic foot ulcers

  This study is testing a special hydrogel treatment with stem cells to see if it can help heal diabetic foot ulcers safely over two years.

  Recruiting at 4 sites Anterogen Co., Ltd. · Bucheon-si, Gyeonggi-do and 3 other locations · NCT06141811

• Identifying biomarkers for healing diabetic foot ulcers

  This study is trying to find specific markers in the body that can help predict which diabetic foot ulcers are likely to heal, so doctors can better manage treatment for patients with these wounds.

  Recruiting at 8 sites University of Michigan · Tucson, Arizona and 8 other locations · NCT06104969

• Wearable Insoles to Help Prevent Diabetic Foot Ulcers

  This study tests Orpyx sensory insoles added to standard care to see if they reduce diabetic foot ulcers in high-risk adults with neuropathy.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05950659

• Evaluating ENERGI-F703 GEL for diabetic foot ulcers

  This study is testing if a new gel can help heal diabetic foot ulcers that haven't improved for at least four weeks.

  Recruiting at 24 sites Phase 3 Energenesis Biomedical Co., Ltd. · Miami, Florida and 23 other locations · NCT05930210

• Comparing a new wound dressing for diabetic foot ulcers to standard care

  This study is testing a new wound dressing for diabetic foot ulcers to see if it works better than the usual treatment.

  Recruiting at 2 sites Community Pharmacology Services Ltd · Airdrie, North Lanarkshire and 1 other locations · NCT05762432

• Evaluating the COMS One device for treating diabetic foot ulcers

  This study is testing a new device called COMS One to see if it can help people with stubborn diabetic foot ulcers heal faster compared to a fake device while they also receive regular care.

  Recruiting at 26 sites Piomic Medical · Mesa, Arizona and 29 other locations · NCT05758545

• Using stem cells from fat to treat diabetic foot ulcers

  This study is testing if using stem cells from fat, along with a special blood product, can help heal chronic foot ulcers in people with diabetes.

  Recruiting Phase 1 University of the Punjab · Lahore, Punjab Province · NCT05610865

• Tracking the healing of chronic wounds with a special dressing

  This study is testing a special dressing called Mepilex Up to see if it helps people with chronic wounds, like venous leg ulcers and diabetic foot ulcers, heal better over six weeks.

  Recruiting at 4 sites Molnlycke Health Care AB · Castro Valley, California and 3 other locations · NCT05588583

• Comparing two treatments for diabetic foot ulcers

  This study is testing which wound cleaner, Hypochlorous Acid or Polyhexamethylene biguanide, works better for healing diabetic foot ulcers in people over a period of up to 24 weeks.

  Recruiting Vastra Gotaland Region · Uddevalla, Trollhattan · NCT05132179

• Sorbact dressings in hard-to-heal wounds

  This study tests whether Sorbact dressings can bind bacteria and fungi from hard-to-heal wounds in adults.

  Recruiting ABIGO Medical AB · Mölndal · NCT05089890

• Using a new micro water jet technology for wound healing

  This study is testing a new water jet device to see if it helps heal different types of wounds better than the usual sharp tools.

  Recruiting Medaxis, LLC · Bradenton, Florida · NCT04920253

• Exercise improves healing of diabetic foot ulcers

  This study is testing if a 12-week exercise program can help people with Type 2 diabetes heal their foot ulcers faster compared to just standard wound care.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT04791449

• Understanding the prognosis of diabetic foot ulcers

  This study looks at how long people with diabetic foot ulcers live and what affects their health over five years, while also checking how these ulcers impact their quality of life and healthcare costs in France.

  Recruiting at 23 sites University Hospital, Bordeaux · Caen and 25 other locations · NCT04533152

• Using smart boots to improve adherence in diabetic foot ulcer treatment

  This study is testing whether different types of diabetic boots can help people with foot ulcers stick to their treatment and heal better.

  Recruiting at 4 sites Phase 2 University of Southern California · Downey, California and 3 other locations · NCT04460573

• Using a special cast to heal diabetic foot ulcers

  This study tests whether a special soft cast can help heal diabetic foot ulcers better than regular methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04210089

• Gait analysis and orthotic correction to prevent diabetic foot ulcers and amputations

  This study tests if using special software to analyze walking patterns and creating custom foot supports can help people with a history of diabetic foot ulcers avoid getting them again and reduce the risk of amputations.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT04164641

• Shorter treatment for diabetic foot ulcers using custom felt relief

  This study is testing if custom felt relief can help people with diabetic foot ulcers heal faster than standard treatments.

  Recruiting Helse Møre og Romsdal HF · Molde · NCT04058639

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design

  A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11640036

• Home-based exercise to help Veterans recover after healed diabetic foot ulcers

  A home-based exercise program for Veterans who recently healed from a diabetic foot ulcer to improve walking and daily function.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511696

• Wound fluid test to predict healing in diabetic foot ulcers

  This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11323031

• Identifying biomarkers in wound fluid for diabetic foot ulcers

  This study is looking at special substances in the fluid from diabetic foot ulcers to see if they can help doctors predict how well the wounds will heal, which could lead to better and more personalized treatments for people with these types of wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11309403

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it's creating a special test to help doctors understand how well these wounds are healing so they can provide better, personalized care for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11166816

• Home exercise program to help Veterans recover after a recently healed diabetic foot ulcer

  A home-based exercise program designed to help Veterans who recently healed from a diabetic foot ulcer regain strength, mobility, and independence.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11132619

• Understanding Diabetic Foot Ulcer Healing

  This project aims to find a way to predict how well diabetic foot ulcers will heal by looking at specific markers related to inflammation.

  NIH research Drexel University · Philadelphia, United States · NIH-11121939

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it aims to find specific genes that can help predict how well these wounds will heal, so that doctors can better manage treatment for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11090049

• Improving treatment for diabetic foot ulcers with a new hydrogel

  This study is testing a new gel that helps heal diabetic foot ulcers by slowly releasing a special growth factor, making it easier for people with diabetes to recover without needing to change their dressings as often.

  NIH research Gelsana Therapeutics, INC. · Aurora, United States · NIH-11007010

• Home-based exercise to help Veterans recover from diabetic foot ulcers

  This study is looking to help Veterans who have recently healed from diabetic foot ulcers get stronger and move better at home through a personalized exercise program, making it easier for them to stay healthy and avoid future problems.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-10923447

• Understanding infections in diabetic foot ulcers and their recurrence

  This study is looking at how infections in diabetic foot ulcers can come back and cause serious problems, like amputations, and it aims to find better ways to detect and treat these infections for people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10854979

• Improving the design of removable cast walkers for diabetic foot ulcers

  This study is looking at how to make removable cast walkers easier to use for people with diabetic foot ulcers, so they can wear them more often and help their feet heal better.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-10843854

• Comparing continuous glucose monitoring to finger stick testing for healing diabetic foot ulcers.

  This study is looking at whether using a continuous glucose monitor (CGM) helps people with diabetic foot ulcers heal better after leaving the hospital compared to the usual finger stick testing, and it’s for patients who have just been treated for these ulcers.

  NIH research Emory University · Atlanta, United States · NIH-10727731

Related topics

Quick answers

How many Diabetic Foot Ulcer clinical trials are recruiting right now?

53, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (32 trials), Norway (2 trials), United Kingdom (2 trials), Egypt (2 trials), Singapore (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 4: 4, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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