Investigating gene markers that affect healing in diabetic foot ulcers
Inflammation-related gene biomarkers in human diabetic foot ulcer healing
This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it aims to find specific genes that can help predict how well these wounds will heal, so that doctors can better manage treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11090049 on NIH RePORTER |
What this research studies
This research focuses on understanding how inflammation impacts the healing of diabetic foot ulcers (DFUs), which affect many diabetic patients. It aims to identify specific gene biomarkers that can predict how well these wounds will heal over time. By analyzing the balance between early-stage inflammatory genes and late-stage resolution genes, the study seeks to develop a composite biomarker known as the Inflammation Index. This index will help determine the responsiveness to treatment and guide better management of DFUs.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients suffering from foot ulcers who are experiencing impaired healing.
Not a fit: Patients without diabetic foot ulcers or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved healing outcomes for patients with diabetic foot ulcers, potentially reducing the need for amputations.
How similar studies have performed: Previous studies have shown promise in using gene expression profiles to predict healing outcomes, indicating that this approach may be effective.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Spiller, Kara Lorraine — Drexel University
- Study coordinator: Spiller, Kara Lorraine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.