Using urinary microRNAs to predict healing in diabetic foot ulcers
Official title: Circulating urinary microRNAs as systemic biomarkers of healing outcomes in diabetic foot ulcers
Funded at University of Miami School of Medicine · NIH-11159351 · Data updated 2026-11-12
This study is looking at how tiny molecules in your urine might help doctors predict if your diabetic foot ulcer will heal with regular treatment or if you might need something more advanced, making it easier to get the right care when you need it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 4, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $379,716 |
| NIH project number | 4R33DK131897-03 |
| Project ID | NIH-11159351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetic foot ulcers who are seeking treatment options.
✕Less likely to help
Patients without diabetic foot ulcers or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the use of urinary microRNAs as non-invasive biomarkers to predict healing outcomes in diabetic foot ulcers (DFUs). By analyzing urine samples, the study aims to identify specific microRNAs that can indicate whether a DFU is likely to heal with standard treatment or if it requires more advanced interventions. The approach involves enrolling patients from existing protocols and utilizing advanced data analysis techniques to develop a reliable prognostic tool. This could significantly improve the management of DFUs by allowing for timely and targeted treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for diabetic foot ulcers, potentially reducing the need for amputations and improving patient quality of life.
How similar studies have gone: Preliminary evidence suggests that using urinary microRNAs as biomarkers has shown promise in similar contexts, indicating potential for success in this approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Stone, Rivka C. — University of Miami School of Medicine
- Study coordinator: Stone, Rivka C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.