Condition

Cystic Fibrosis clinical trials and research

• 69Clinical trials
• 122NIH research projects
• 15Countries

Newest Cystic Fibrosis clinical trials

All recruiting trials (69)

• Inhaled CFTR mRNA for cystic fibrosis in Chinese patients aged 12 and older

  This trial tests inhaled BMD003, a CFTR mRNA therapy, to see if it's safe and shows early signs of benefit in Chinese people 12 years and up with cystic fibrosis.

  Recruiting Early Phase 1 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07485543

• VX-272 dose escalation in healthy adults

  This will test single and multiple increasing doses of the experimental drug VX-272 in healthy adults to see how safe it is and how the body handles it.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Tempe, Arizona · NCT07437105

• Prevalence of smoking, passive smoke exposure, and vaping among adults with cystic fibrosis

  This project will see how common smoking, exposure to secondhand smoke, and vaping are among adults with cystic fibrosis followed at the Strasbourg Adult CF Center.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07342920

• Dose escalation of VX-581 to check safety and drug levels in healthy adults

  The trial will test increasing doses of VX-581 in healthy adults to see if it is safe and to measure how the body absorbs and clears the drug.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Overland Park, Kansas · NCT07283770

• PALMIRE cohort: phenotyping inflammatory lung diseases to enable personalized care

  This project will collect clinical, imaging, and biological data from adults with asthma, COPD, bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, or interstitial lung disease to try to identify disease subtypes and markers that could guide more personalized care.

  Recruiting CHU de Reims · Reims · NCT07274631

• Collecting sputum samples at home for cystic fibrosis patients

  This study is testing if collecting sputum samples at home can help people with cystic fibrosis better identify lung infections compared to traditional methods done at the clinic.

  Recruiting at 4 sites University of Pennsylvania · Denver, Colorado and 3 other locations · NCT06950892

• New device for sweat testing in cystic fibrosis patients

  This study is testing a new device that measures sweat to see if it can help doctors better diagnose cystic fibrosis in patients, healthy individuals, and carriers.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT06836453

• Evaluating ARCT-032 for treating cystic fibrosis in patients not on CFTR modulators

  This study is testing a new treatment called ARCT-032 to see if it can help adults with cystic fibrosis who can't take standard medications feel better and improve their lung function.

  Recruiting at 11 sites Phase 2 Arcturus Therapeutics, Inc. · Tucson, Arizona and 12 other locations · NCT06747858

• Restarting triple modulator therapy with close safety monitoring

  This project tests whether people with cystic fibrosis aged 6 and up who stopped or changed elexacaftor/tezacaftor/ivacaftor (ETI) because of mental health or liver problems can start vanzacaftor/tezacaftor/deutivacaftor (VTD) safely with close monitoring.

  Recruiting at 16 sites Boston Children's Hospital · Birmingham, Alabama and 17 other locations · NCT06683092

• Treatment options for pulmonary exacerbations in children with cystic fibrosis

  This study is testing two different ways to treat lung flare-ups in kids with cystic fibrosis to see which method works better and helps avoid giving antibiotics when they’re not needed.

  Recruiting at 32 sites University of Washington, the Collaborative Health Studies Coordinating Center · Birmingham, Alabama and 32 other locations · NCT06654752

• Organizing care for cystic fibrosis patients using new treatments

  This study looks at how new cystic fibrosis treatments are changing the way care is organized and delivered to patients in France.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06599892

• Using Continuous Glucose Monitoring to Screen for Diabetes in Cystic Fibrosis Patients

  This study is testing if using continuous glucose monitors can help better screen for diabetes in people with cystic fibrosis.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06560463

• Investigating SP-101 gene therapy for cystic fibrosis

  This study is testing a new gene therapy called SP-101 to see if it can help adults with cystic fibrosis who can't use standard treatments.

  Recruiting at 4 sites Phase 1/2 Spirovant Sciences, Inc. · Kansas City, Kansas and 3 other locations · NCT06526923

• Using smartphone technology to evaluate airway conditions

  This study is testing if smartphone technology can help check lung health and spot breathing problems in both healthy people and those with asthma or COPD.

  Recruiting at 2 sites Indiana University · Indianapolis, Indiana and 1 other locations · NCT06512064

• Examining physical activity and sedentary behavior in adults with cystic fibrosis

  This study looks at how active or inactive adults with cystic fibrosis are to see how it affects their health and quality of life.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06507956

• Research to improve treatments for cystic fibrosis patients not on modulators

  This study is trying to find better treatments for people with cystic fibrosis who aren't using current medications by collecting health information and samples to help guide future research.

  Recruiting at 64 sites Seattle Children's Hospital · Birmingham, Alabama and 67 other locations · NCT06504589

• Coordinated diet and exercise program for adults with cystic fibrosis

  This study is testing whether a special diet and exercise program can help adults with cystic fibrosis gain muscle and improve their health while they are on a specific medication.

  Recruiting at 4 sites University Hospital, Tours · Angers and 3 other locations · NCT06457451

• Testing the safety and effectiveness of SPL84 for cystic fibrosis

  This study is testing if the drug SPL84 is safe and effective for adults with cystic fibrosis who have certain genetic mutations.

  Recruiting at 14 sites Phase 2 SpliSense Ltd. · Long Beach, California and 26 other locations · NCT06429176

• Maralixibat for constipation in children with cystic fibrosis

  We will try maralixibat for two weeks to see if it softens stools and makes bowel movements easier in children with cystic fibrosis who still have constipation despite their usual laxatives.

  Recruiting Phase 2/3 Children's Hospital Los Angeles · Los Angeles, California · NCT06413368

• Using losartan to enhance cystic fibrosis treatment response

  This study is testing if adding losartan to the treatment of people with cystic fibrosis already on modulator therapy can help them feel better by improving their sweat chloride levels.

  Recruiting Phase 2 University of Kansas Medical Center · Kansas City, Kansas · NCT06364176

• Survey on Oral Health in Cystic Fibrosis Patients

  This study is trying to understand how cystic fibrosis affects oral health and quality of life for adults by asking them about their dental experiences through an online survey.

  Recruiting Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine, Île-de-France Region · NCT06356246

• Monitoring lung changes in cystic fibrosis patients

  This study is testing new ways to see how stopping and starting airway clearance therapy affects lung health in people with cystic fibrosis.

  Recruiting Early Phase 1 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06339593

• e-Health program to prevent lung issues in cystic fibrosis patients

  This study is testing a new online program to see if it can help people with cystic fibrosis manage their lung health better than standard treatment alone.

  Recruiting University of Valencia · Valencia · NCT06313827

• Observing the effects of CFTR modulators in pregnant women with cystic fibrosis and their newborns

  This study looks at how CFTR modulators affect pregnant women with cystic fibrosis and their newborns to see if the treatment impacts their health and the babies’ health, including any effects from breast milk.

  Recruiting Region Stockholm · Stockholm · NCT06302270

• Impact of Parenthood on Health in People with Cystic Fibrosis

  This study looks at how becoming a parent affects the health of people with cystic fibrosis, especially their lung function and mental well-being, over five years.

  Recruiting at 18 sites University of Pittsburgh · Birmingham, Alabama and 17 other locations · NCT06296394

• Validation of a French questionnaire for cystic fibrosis patients

  This study is testing a new French questionnaire to see if it can help young adults with cystic fibrosis stick to their physiotherapy treatments better.

  Recruiting Pole Sante Grace de Dieu · Caen · NCT06273566

• Evaluating bone health in adolescents with cystic fibrosis

  This study is testing how bone health in teenagers with cystic fibrosis compares to their healthy peers to see if higher fat in their bone marrow affects their bone strength.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06216704

• Impact of CFTR Modulators on Sinus Health in Young Children with Cystic Fibrosis

  This study is testing if a new treatment for cystic fibrosis can improve sinus health and smell in young children aged 2-8.

  Recruiting at 6 sites University of California, Los Angeles · Aurora, Colorado and 5 other locations · NCT06191640

• Examining hormonal responses to meals in cystic fibrosis patients

  This study looks at how people with cystic fibrosis react hormonally to meals to see if these responses are linked to problems with blood sugar control.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06163482

• Non-invasive prenatal diagnosis for single gene disorders

  This study is testing a new way to safely diagnose single-gene disorders in unborn babies using a simple blood test from the mother, starting as early as 9 weeks into the pregnancy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06147414

• Validation of the MuCopilot app for assessing cystic fibrosis

  This study is testing a new app that helps people with cystic fibrosis check their lung function and exercise ability at home to see if it’s safe and easy to use.

  Recruiting Ad scientiam · Rouen · NCT06132048

• Measuring lung function in cystic fibrosis using advanced MRI techniques

  This study is testing a new MRI method to see how well the lungs are working in people with cystic fibrosis over a year, comparing it to standard lung tests.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06057714

• Building primary epididymal cell models to look at CFTR gene regulation

  This project will try to grow cells from epididymal tissue taken during planned surgery to see if they reveal how the CFTR gene is regulated in adult men with infertility, cystic fibrosis, or absence of the vas deferens.

  Recruiting University Hospital, Brest · Brest · NCT06045702

• Education program for lung transplant discussions in cystic fibrosis

  This study is testing a new education program to help people with cystic fibrosis and their caregivers talk more about lung transplants and make better decisions about their options.

  Recruiting University of Washington · Seattle, Washington · NCT06032273

• A new sweat sensor device for diagnosing cystic fibrosis

  This study is testing a new sweat sensor to see if it can make diagnosing cystic fibrosis easier and more accurate for both patients with the condition and healthy volunteers.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT05998629

• Effects of Modulator Therapy on Cystic Fibrosis Microbiome

  This study is trying to see how a new treatment for cystic fibrosis affects the bacteria in the sinuses and overall health of adults with the condition.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT05982795

• Exploring the effects of a new cystic fibrosis treatment on lung and gut health

  This study is testing a new combination therapy for cystic fibrosis to see how it affects lung and gut health in people aged 12 and older with certain genetic mutations.

  Recruiting at 15 sites University Hospital, Bordeaux · Bordeaux and 14 other locations · NCT05937815

• Assessing a new inhaled treatment for cystic fibrosis

  This study is testing a new inhaled treatment for cystic fibrosis to see if it is safe and effective for people with the condition.

  Recruiting at 5 sites Phase 1 Cystetic Medicines, Inc. · Canberra, Australian Capital Territory and 4 other locations · NCT05802264

• Investigating the impact of diet on diabetes risk in cystic fibrosis patients

  This study is testing if a low-added sugar, high-fat diet can lower diabetes risk in adults with cystic fibrosis compared to a standard high-sugar diet.

  Recruiting Emory University · Atlanta, Georgia · NCT05766774

• Effects of a Low Glycemic Load Diet on Diabetes and Body Composition in Adults with Cystic Fibrosis

  This study is testing if a low glycemic load diet can help adults with cystic fibrosis-related diabetes manage their blood sugar and improve their overall health.

  Recruiting at 2 sites Rhode Island Hospital · Boston, Massachusetts and 1 other locations · NCT05723445

• Effects of estrogen on bone health in women with cystic fibrosis

  This study is testing how estrogen and hormonal birth control affect bone health in young women with cystic fibrosis.

  Recruiting Phase 4 Johns Hopkins University · Baltimore, Maryland · NCT05704036

• Comparing antibiotic treatments for lung issues in cystic fibrosis

  This study is testing whether a combination of two types of antibiotics can help people with cystic fibrosis recover better from lung problems than using just one type of antibiotic.

  Recruiting at 59 sites Phase 4 Seattle Children's Hospital · Birmingham, Alabama and 59 other locations · NCT05548283

• Assessing KB407 for treating cystic fibrosis

  This study is testing a new inhaled treatment called KB407 to see if it is safe and how well it works for adults with cystic fibrosis.

  Recruiting at 6 sites Phase 1 Krystal Biotech, Inc. · Gainesville, Florida and 5 other locations · NCT05504837

• Registry for measuring respiratory health in children

  This study is collecting information on lung health in children, especially those with cystic fibrosis and other breathing issues, to see how well a new testing method works compared to standard tests.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05501587

• Exploring the effects of exercise on children's health with chronic diseases

  This study is testing how exercise can improve the health of children with chronic diseases like cystic fibrosis and sickle cell disease to find safe ways for them to be active.

  Recruiting University of California, Irvine · Irvine, California · NCT05359991

• Effects of Trikafta on exercise and breathing in cystic fibrosis patients

  This study tests how the drug Trikafta affects breathing and exercise ability in people with cystic fibrosis.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05279040

• Observational study on the long-term effects of CFTR modulators in cystic fibrosis patients

  This study looks at how well CFTR modulator treatments, like Trikafta, work for people with cystic fibrosis over time by gathering health information and feedback from patients across Canada.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT05200429

• Using continuous glucose monitoring to identify diabetes risk in cystic fibrosis patients

  This study is testing if continuous glucose monitoring can help find out which cystic fibrosis patients are at risk for diabetes by tracking their health over five years.

  Recruiting Institut de Recherches Cliniques de Montreal · Montreal, Quebec and 3 other locations · NCT05099939

• Investigating lung disease markers in cystic fibrosis and bronchiectasis patients

  This study is trying to see if special imaging techniques can help doctors understand how lung disease is getting worse in kids with cystic fibrosis and bronchiectasis, even if their breathing tests look normal.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04793867

• Evaluating CFTR function in cystic fibrosis patients treated with CFTR modulators

  This study is testing how well CFTR modulators work for people with cystic fibrosis by looking at changes in their body functions and health over a year.

  Recruiting at 4 sites Charite University, Berlin, Germany · Berlin, State of Berlin and 3 other locations · NCT04732910

• Using GLP-1 therapy to improve glucose tolerance in cystic fibrosis patients

  This study is testing if a weekly injection of a diabetes medication can help adults with cystic fibrosis improve their blood sugar levels and insulin response.

  Recruiting at 2 sites Phase 2 University of Pennsylvania · Aurora, Colorado and 1 other locations · NCT04731272

• Using hyperpolarized 129Xe MRI to assess lung function in healthy individuals and those with lung diseases

  This study is testing a special type of MRI using hyperpolarized gas to see how well it can check lung function in both healthy people and those with lung diseases like asthma and COPD.

  Recruiting Phase 1 University of Kansas Medical Center · Kansas City, Kansas · NCT04624490

• Testing drug effectiveness for cystic fibrosis using personalized medicine

  This study is testing if personalized medicine can help find the best CF treatments for people with rare cystic fibrosis gene mutations by using their own nasal cells.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04580368

• Metformin's effects on lung function in patients with cystic fibrosis-related diabetes

  This study is testing if metformin can help improve lung function in people with cystic fibrosis-related diabetes by giving them different doses of the medication over 14 weeks.

  Recruiting Phase 2 University of Kansas Medical Center · Kansas City, Kansas · NCT04530383

• Evaluating the effects of CFTR modulators in young children with cystic fibrosis

  This study is testing how CFTR modulators affect growth and health in young children with cystic fibrosis over five years.

  Recruiting at 35 sites Seattle Children's Hospital · Birmingham, Alabama and 34 other locations · NCT04509050

• Examining the effects of sinus surgery on cystic fibrosis patients

  This study is testing whether sinus surgery can improve health and quality of life for cystic fibrosis patients who have ongoing sinus problems, compared to those just getting medical treatment.

  Recruiting at 9 sites University of California, Los Angeles · Los Angeles, California and 8 other locations · NCT04469439

• Evaluating a biomarker for cystic fibrosis in children

  This study is testing whether a specific biomarker can help predict the risk of lung infections in children with cystic fibrosis.

  Recruiting University Hospital, Brest · Roscoff · NCT04137133

• Understanding how body fat affects health in cystic fibrosis

  This study looks at how body fat affects health in young adults with cystic fibrosis by comparing their body composition and health to that of healthy volunteers.

  Recruiting Emory University · Birmingham, Alabama and 1 other locations · NCT04002882

• Investigating bone health in cystic fibrosis patients

  This study is testing how bone health is affected in people with cystic fibrosis and whether a medication called denosumab can help improve it.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT03921060

• Correcting genetic mutations in cystic fibrosis

  This study is testing new treatments that could fix specific genetic mistakes in the CFTR gene to help people with cystic fibrosis breathe better and improve their health.

  Recruiting at 8 sites University Hospital, Lille · Amiens and 7 other locations · NCT03670472

• Exploring new treatments for cystic fibrosis using existing medications

  This study is testing if existing cystic fibrosis medications can help improve lung function in patients with specific gene mutations who are at least 6 years old.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT03587961

• Collecting samples from patients with rare cystic fibrosis mutations

  This study is collecting samples from people with rare cystic fibrosis mutations to help researchers find new treatments for their condition.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT03161808

• Creating a questionnaire to assess abdominal issues in cystic fibrosis patients

  This study is trying to create a new questionnaire to help cystic fibrosis patients report their abdominal issues so that doctors can better understand and treat them.

  Recruiting at 2 sites Medizinische Hochschule Brandenburg Theodor Fontane · Brandenburg an der Havel and 1 other locations · NCT03052283

• Using Xenon-129 MRI to Study Lung Function in Healthy and Diseased Lungs

  This study is testing a new type of MRI using a special gas to see if it can help us understand lung function better in people with cystic fibrosis and asthma compared to healthy individuals.

  Recruiting Phase 2 The Hospital for Sick Children · Toronto, Ontario · NCT02740868

• Understanding the progression of Noncirrhotic Portal Hypertension

  This study is trying to learn more about how Noncirrhotic Portal Hypertension develops and changes over time by looking at the health of up to 400 people aged 12 and older who have or are at risk for this condition.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02417740

• Examining genetics related to insulin and incretins in cystic fibrosis

  This study is trying to see how certain genes affect insulin and blood sugar levels in people with cystic fibrosis to better understand diabetes related to the condition.

  Recruiting at 2 sites Children's Hospital of Philadelphia · Philadelphia, Pennsylvania and 1 other locations · NCT01852448

• Understanding how incretin hormones affect insulin in cystic fibrosis patients

  This study tests if giving incretin hormones can help improve insulin production in cystic fibrosis patients who have diabetes.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT01851694

• Understanding the natural history of bronchiectasis

  This study looks at how bronchiectasis develops over time in people with chronic lung infections, especially focusing on genetic and immune factors that might make them more prone to these infections.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00943514

• Exploring genetic factors in lung disease development

  This study is trying to find out how certain genes might play a role in lung diseases like cystic fibrosis and asthma by looking at lung cells from both patients and healthy people.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT00001532

NIH-funded research (newest 40 of 122)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Blocking CFTR in the cervix to prevent conception without hormones

  A non-hormonal approach aims to stop sperm from entering the uterus by making cervical mucus too thick for sperm, potentially offering a new contraception option.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11565149

• Optimizing Treatments for People with Cystic Fibrosis on Highly Effective Modulator Therapy

  A real-world study in people with cystic fibrosis on highly effective CFTR modulator therapy to understand how traditional CF treatments can be adjusted safely.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11465858

• Elastin-like particles to deliver gene therapies for cystic fibrosis

  A new nanoparticle system is being developed to deliver genetic therapies directly to the lungs of people with cystic fibrosis, including those with nonsense mutations.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11447142

• Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS

  A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11445429

• Ceftaroline-meropenem combo to beat MRSA in cystic fibrosis

  A new combination antibiotic approach is being tested to help people with cystic fibrosis who have MRSA infections that resist standard treatments.

  NIH research Mainehealth · Portland, United States · NIH-11439521

• Gut microbiome in cystic fibrosis and colorectal cancer risk

  Researchers are studying how the gut bacteria in adults with cystic fibrosis influence the development of colorectal cancer.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11436161

• New peptide medicines to help cystic fibrosis–related diabetes

  A small, patient-friendly study tests new peptide-based therapies aimed at improving insulin production and reducing pancreatic inflammation in people with CFRD.

  NIH research Eldec Pharmaceuticals, INC. · Durham, UNITED STATES · NIH-11424457

• Smart breath test to detect cystic fibrosis flare-ups in kids with a smartphone app

  A hand-held, real-time breath test using a smartphone app and a tiny sensor aims to spot worsening lung problems early in children with cystic fibrosis.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11416575

• Carbonic Anhydrase–Linked Changes in Cell Transport and Infection in Cystic Fibrosis

  A clinician-scientist is studying how a specific enzyme affects lung cell movement and bacterial sticking in cystic fibrosis to find new ways to reduce infections.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11413541

• Understanding how CFTR affects fat absorption in the small intestine

  This grant study looks at why people with cystic fibrosis have trouble absorbing fat in the gut and how this may affect nutrition and health from infancy onward.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11411468

• Oxy210 as an anti-fibrotic and immune-modulating approach for cystic fibrosis

  A small-fund, early-phase program tests whether Oxy210 can reduce lung scarring and abnormal immune responses in people with cystic fibrosis.

  NIH research Max Biopharma, INC. · Los Angeles, United States · NIH-11403555

• Pseudomonas phage: a new angle to treat chronic lung infections in cystic fibrosis

  A researcher at Stanford is studying how a virus that infects Pseudomonas bacteria (Pf phage) may help us understand and fight chronic lung infections in people with cystic fibrosis.

  NIH research Stanford University · Stanford, United States · NIH-11400318

• Durable gene therapy for CF: delivering fixes to airway basal cells

  Aims to develop a special inhaled gene-delivery system to reach airway stem cells in people with cystic fibrosis who have certain mutations, offering a potential lasting correction.

  NIH research University of Texas at Austin · Austin, United States · NIH-11394545

• Non-invasively measuring early lung changes in cystic fibrosis with MRI

  A study will use a radiation-free MRI technique to detect early lung changes in people with cystic fibrosis, including children and adults, to help guide ongoing care.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11383584

• Gallium treatment for cystic fibrosis patients with non-tuberculous mycobacteria

  A patient-centered study tests whether IV gallium nitrate can help CF patients whose lungs are colonized by non-tuberculous mycobacteria.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11380360

• Dietary changes to prevent glucose problems in adults with cystic fibrosis

  A nutrition-focused study in adults with cystic fibrosis will test how eating quality sugars affects the development of glucose intolerance and CFRD.

  NIH research Emory University · Atlanta, United States · NIH-11378277

• Role of anaerobic bacteria in early cystic fibrosis airway disease

  A research project will explore how anaerobic bacteria living in the lungs of children with cystic fibrosis may influence early disease progression and response to treatment.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11362044

• Georgia Cystic Fibrosis Data Warehouse goes cloud-enabled for many sites

  A program will turn the Georgia CF Data Warehouse into an automated, scalable cloud system that can join with other CF centers to support nationwide data sharing.

  NIH research Emory University · Atlanta, United States · NIH-11358139

• Understanding CFTR Modulators in Pregnancy for Moms and Babies

  We’re studying how CFTR-modifying medicines behave in pregnant people with cystic fibrosis and what that means for moms and their babies.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11357553

• Glucose and amino acid transport as targets to boost CF immune responses

  This grant explores how glucose and amino acid transport in immune cells may be linked to better outcomes for adults with cystic fibrosis who still have lung infections despite standard therapies.

  NIH research National Jewish Health · Denver, United States · NIH-11357262

• Targeting airway BK channels to help mucus clearance in cystic fibrosis and COPD

  A first-in-class inhaled treatment aims to open specific airway channels to help clear mucus for people with cystic fibrosis or COPD.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11353188

• Verapamil for beta cell function in teens and adults with CF-related dysglycemia

  A small study will test whether the blood pressure medicine verapamil can help preserve insulin-producing cells in people with cystic fibrosis–related dysglycemia, including teens and adults.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11340008

• Sinus disease in young children with cystic fibrosis

  A study will follow children with cystic fibrosis to understand how sinus problems and sense of smell change as they begin highly effective CF medicines.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11333251

• Optimizing combination therapies for rare CF variants

  A study at Purdue University aims to find better drug combinations to help people with rare cystic fibrosis mutations.

  NIH research Purdue University · West Lafayette, United States · NIH-11333209

• How CFTR genes affect cystic fibrosis and carrier health

  Looks at how different versions of the CFTR gene change how nasal cells move salt and fluid in people with cystic fibrosis, carriers, and people without mutations.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11331285

• SGLT-blocking drugs for cystic fibrosis–related liver disease

  This work asks whether drugs that block SGLT proteins could help people with cystic fibrosis who have liver disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11327256

• Non-viral gene editing to fix cystic fibrosis stop mutations

  This project tests inhaled, non-viral gene editing to correct premature 'stop' mutations in the CFTR gene for people with cystic fibrosis caused by nonsense mutations.

  NIH research University of Toronto · Toronto, Canada · NIH-11320879

• Why lung inflammation stays active in cystic fibrosis

  This research looks at immune cells in people with cystic fibrosis to understand why lung inflammation keeps going even after CFTR medicines.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11318977

• AAV gene therapy to fix the CFTR defect in cystic fibrosis

  A lung-targeted AAV gene therapy aims to deliver a corrected CFTR gene to help people with cystic fibrosis, including those whose mutations are not helped by existing drugs.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11312654

• Gene-editing approaches to correct the CFTR gene in cystic fibrosis

  New gene-editing methods aim to permanently fix the CFTR gene for people with cystic fibrosis.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11306696

• How cystic fibrosis modulator medicine affects young children's lungs and pancreas

  This project looks at whether the triple-drug CF medicine ETI helps protect and improve lung health and pancreatic function in young children with cystic fibrosis.

  NIH research Emory University · Atlanta, United States · NIH-11306644

• Ciliated nasal cells and bitter taste receptors in CF and CRS

  Researchers are studying how taste receptors in nasal ciliated cells help fight infections in cystic fibrosis and chronic rhinosinusitis, aiming to boost natural defenses.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11295042

• Breath tests to spot Staphylococcus aureus lung infections in cystic fibrosis patients

  A non-invasive breath test study aims to detect S. aureus lung infections in people with cystic fibrosis using existing data and breath analysis.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11293980

• Georgia Cystic Fibrosis Data Hub

  This project builds a secure collection of medical records and patient samples to help researchers and clinicians learn more about cystic fibrosis for people treated in Georgia.

  NIH research Emory University · Atlanta, United States · NIH-11290718

• Targeting age-related cell changes in cystic fibrosis lungs

  Researchers will test whether changing epigenetic signals can reduce harmful aging-like changes in lung cells of people with cystic fibrosis.

  NIH research Old Dominion University · Norfolk, United States · NIH-11289383

• Understanding how the CF gene affects early lung development using lab-grown 3-D lung organoids

  This project uses 3-D lab-grown lung models to see how CFTR problems affect early lung development so treatments for babies and children with cystic fibrosis can be improved.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11288957

• Home air pollution and lung health in children with cystic fibrosis

  This project looks at how air pollution in and around the home affects lung health in children with cystic fibrosis, with a focus on Hispanic children who often have worse outcomes.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11272152

• Understanding Sinus Issues in Young Children with Cystic Fibrosis

  This research looks at how sinus problems and sense of smell are affected in young children with cystic fibrosis and if a special medicine can help.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11269107

• Developing new gene editing therapies for cystic fibrosis

  This study is working on new gene editing treatments for people with cystic fibrosis who have rare gene changes, using special materials to deliver medicine directly to the lungs and testing these treatments in the lab to help improve care for CF and similar conditions.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11265024

• How cystic fibrosis lung conditions help nontuberculous mycobacteria form biofilms

  This project looks at how the lung environment in people with cystic fibrosis helps antibiotic-resistant nontuberculous mycobacteria form protective biofilms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11262895

Related topics

Quick answers

How many Cystic Fibrosis clinical trials are recruiting right now?

69, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (44 trials), France (15 trials), Canada (7 trials), Germany (3 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 5, Early Phase 1: 3, Phase 4: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →