Understanding Sinus Issues in Young Children with Cystic Fibrosis
Official title: Sinus Disease in Young Children with Cystic Fibrosis
Funded at University of California Los Angeles · NIH-11269107 · Data updated 2026-11-12
This research looks at how sinus problems and sense of smell are affected in young children with cystic fibrosis and if a special medicine can help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $110,250 |
| NIH project number | 3R01HL174913-02S1 |
| Project ID | NIH-11269107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young children, aged 0-11 years, who have been diagnosed with cystic fibrosis.
✕Less likely to help
Patients who are adults with cystic fibrosis or those without sinus issues or olfactory dysfunction may not directly benefit from this specific research.
What this research studies
Cystic fibrosis often causes thick mucus that can lead to ongoing sinus problems and affect a child's sense of smell, which can impact their daily life and overall health. While a highly effective medicine called HEMT has helped adults with cystic fibrosis improve their sinus issues, it hasn't fully restored their sense of smell or completely cleared their sinuses. This project aims to understand these problems better in young children and see if starting HEMT early can lead to even greater improvements in both sinus health and sense of smell. We hope that by treating children before these issues become severe, we can achieve better long-term outcomes.
Why it matters
Potential benefit: If successful, this work could lead to better treatments for sinus problems and improved sense of smell for young children with cystic fibrosis, enhancing their quality of life.
How similar studies have gone: Previous research has shown that highly effective CF modulator therapy improves sinus issues in adults with cystic fibrosis, but its impact on olfactory dysfunction and complete sinus resolution in young children is still being explored.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Beswick, Daniel M — University of California Los Angeles
- Study coordinator: Beswick, Daniel M
Related research
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-
Optimizing Treatments for People with Cystic Fibrosis on Highly Effective Modulator Therapy
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-
Elastin-like particles to deliver gene therapies for cystic fibrosis
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Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS
A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.
-
Ceftaroline-meropenem combo to beat MRSA in cystic fibrosis
A new combination antibiotic approach is being tested to help people with cystic fibrosis who have MRSA infections that resist standard treatments.
-
Gut microbiome in cystic fibrosis and colorectal cancer risk
Researchers are studying how the gut bacteria in adults with cystic fibrosis influence the development of colorectal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.