Understanding Sinus Issues in Young Children with Cystic Fibrosis
Sinus Disease in Young Children with Cystic Fibrosis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11269107
This research looks at how sinus problems and sense of smell are affected in young children with cystic fibrosis and if a special medicine can help.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11269107 on ClinicalTrials.gov |
What this research studies
Cystic fibrosis often causes thick mucus that can lead to ongoing sinus problems and affect a child's sense of smell, which can impact their daily life and overall health. While a highly effective medicine called HEMT has helped adults with cystic fibrosis improve their sinus issues, it hasn't fully restored their sense of smell or completely cleared their sinuses. This project aims to understand these problems better in young children and see if starting HEMT early can lead to even greater improvements in both sinus health and sense of smell. We hope that by treating children before these issues become severe, we can achieve better long-term outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children, aged 0-11 years, who have been diagnosed with cystic fibrosis.
Not a fit: Patients who are adults with cystic fibrosis or those without sinus issues or olfactory dysfunction may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better treatments for sinus problems and improved sense of smell for young children with cystic fibrosis, enhancing their quality of life.
How similar studies have performed: Previous research has shown that highly effective CF modulator therapy improves sinus issues in adults with cystic fibrosis, but its impact on olfactory dysfunction and complete sinus resolution in young children is still being explored.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BESWICK, DANIEL M — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: BESWICK, DANIEL M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections