Building primary epididymal cell models to look at CFTR gene regulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project collects epididymal tissue samples during scheduled urologic surgery and establishes primary epididymal cell cultures. Researchers will map the 3D organization of chromatin at the CFTR locus and identify regulatory elements active in these cells. Participants include adult men undergoing epididymal sampling, including those with male infertility, cystic fibrosis, or congenital bilateral absence of the vas deferens. The goal is to connect CFTR regulatory architecture in epididymal cells to mechanisms underlying certain forms of male infertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male patients over 18 years of age
* Patients, without genetic pathology, scheduled for epididymal sampling surgery
* Patients with cystic fibrosis or bilateral vas deferens agenesis, scheduled for epididymal sampling surgery.
* Signature of a consent form

Exclusion Criteria:

* Patients not scheduled for epididymal harvesting surgery
* Patients under legal protection (guardianship, curatorship)
* Refusal to participate

Where it's running

• Antoine VALERI
  Brest, France Recruiting

Study contacts

• Principal investigator: Antoine VALERI, MD,PhD — University Hospital, Brest
• Study coordinator: Antoine VALERI, MD,PhD
• Email: Antoine.Valeri@univ-brest.fr
• Phone: +33298347170

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.