Blocking CFTR in the cervix to prevent conception without hormones
Official title: Inhibiting the cystic fibrosis transmembrane conductance regulator (CFTR) in the cervix as a novel approach to non-hormonal contraception
Funded at Oregon Health & Science University · NIH-11565149 · Data updated 2026-11-12
A non-hormonal approach aims to stop sperm from entering the uterus by making cervical mucus too thick for sperm, potentially offering a new contraception option.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $826,077 |
| NIH project number | 4R33HD114161-03 |
| Project ID | NIH-11565149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals seeking non-hormonal contraception, particularly those concerned about hormone-related side effects.
✕Less likely to help
People who rely on fertility methods that require cervical mucus changes or who cannot use CFTR-targeted approaches may not benefit.
What this research studies
This project explores blocking CFTR in endocervical cells to keep cervical mucus viscous around midcycle, which would prevent sperm from moving through the cervix. The work combines lab studies with a plan to move toward human use, focusing on how CFTR controls mucus and fluid balance in the cervix. If successful, this could lead to a non-hormonal contraception method that preserves normal menstrual cycling. The research emphasizes safety and feasibility in existing models before any clinical steps.
Why it matters
Potential benefit: If successful, it could provide a new non-hormonal option for contraception that preserves overall hormonal balance and cycle regularity.
How similar studies have gone: Prior work has established CFTR’s role in cervical mucus regulation, with preliminary data supporting this mechanism in endocervical tissues.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Han, Leo Liu — Oregon Health & Science University
- Study coordinator: Han, Leo Liu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.