Carbonic Anhydrase–Linked Changes in Cell Transport and Infection in Cystic Fibrosis
Official title: Carbonic Anhydrase Mediated Regulation of Microtubule Dynamics and Infection in Cystic Fibrosis
Funded at Lurie Children's Hospital of Chicago · NIH-11413541 · Data updated 2026-11-12
A clinician-scientist is studying how a specific enzyme affects lung cell movement and bacterial sticking in cystic fibrosis to find new ways to reduce infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $163,080 |
| NIH project number | 5K08HL179453-02 |
| Project ID | NIH-11413541 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cystic fibrosis whose airway cells can be studied in vitro or who could participate in related future trials based on the findings.
✕Less likely to help
Individuals without CF or without airway involvement may not benefit from this specific research.
What this research studies
In cystic fibrosis, frequent lung infections lead to serious health problems. This project explores how low levels of carbonic anhydrase change how lung cells move internal cargo and organize their surfaces, which may make bacteria like Pseudomonas stick more easily. The team uses live-cell imaging, biochemical tests, proteomics, and tests of how bacteria adhere to cells to test their ideas. They will focus on two enzymes (CA2 and CA12) and how they influence transport and membrane organization, then look for the factors that drive bacterial binding. If successful, the work could reveal new targets to improve infection control in CF patients.
Why it matters
Potential benefit: Could lead to new strategies to prevent or reduce lung infections in people with CF by targeting cellular transport and bacterial adhesion pathways.
How similar studies have gone: Prior CF research has shown that cellular transport and membrane organization influence infection, with ongoing exploration adding to a growing body of supportive data.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Boyne, Kathleen L — Lurie Children's Hospital of Chicago
- Study coordinator: Boyne, Kathleen L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.