Role of anaerobic bacteria in early cystic fibrosis airway disease
Official title: The role of anaerobic microbiota in cystic fibrosis airway disease trajectory
Funded at State University of New York at Buffalo · NIH-11362044 · Data updated 2026-11-12
A research project will explore how anaerobic bacteria living in the lungs of children with cystic fibrosis may influence early disease progression and response to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $600,717 |
| NIH project number | 5R01AI177613-05 |
| Project ID | NIH-11362044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with cystic fibrosis whose lungs are affected by anaerobic bacterial communities may be involved in future translational work or benefit from discoveries.
✕Less likely to help
Patients whose CF airway disease is not driven by anaerobic bacteria may see limited direct benefit.
What this research studies
In this project, scientists will study how anaerobic microbes interact with each other, the airway lining, and usual CF pathogens like Pseudomonas and Staphylococcus. They will use models that mimic the CF airway environment to understand these interactions and how they affect inflammation and antibiotic responses. The goal is to identify mechanisms by which anaerobes contribute to early CF lung disease and to inform potential therapeutic strategies. This work comes from prior findings that anaerobes colonize airways early and can drive inflammatory responses and changes in pathogen behavior.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to manage early CF airway disease by targeting anaerobic bacteria or their interactions.
How similar studies have gone: Recent work has shown anaerobes colonize pediatric CF airways and influence inflammation and pathogen behavior; this study builds on those findings in a mechanistic, model-based approach.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Hunter, Ryan Coulson — State University of New York at Buffalo
- Study coordinator: Hunter, Ryan Coulson
Related research
Other NIH-funded projects on the same topics.
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Understanding Anaerobic Bacteria in Cystic Fibrosis Airways
This research explores how certain bacteria in the lungs of people with cystic fibrosis affect their health, especially in children.
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Understanding how certain bacteria affect lung disease in cystic fibrosis
This study is looking at how certain bacteria in the lungs of young people with cystic fibrosis might affect their lung health and how they respond to treatments, with the hope of finding better ways to help manage their condition.
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Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS
A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.