Understanding CFTR Modulators in Pregnancy for Moms and Babies
Official title: Evaluating Maternal and Neonatal Pharmacokinetics of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators - The ELECTRA Pregnancy Study
Funded at Arkansas Children's Hospital Res Inst · NIH-11357553 · Data updated 2026-11-12
We’re studying how CFTR-modifying medicines behave in pregnant people with cystic fibrosis and what that means for moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | July 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $635,230 |
| NIH project number | 5R01HD117940-02 |
| Project ID | NIH-11357553 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people with cystic fibrosis (and those planning pregnancy) who are on or considering CFTR modulator therapy.
✕Less likely to help
Pregnant people not using CFTR modulators or those without CF-related health concerns related to pregnancy may not benefit.
What this research studies
This study will look at how the CFTR modulator combination elexacaftor/tezacaftor/ivacaftor flows through the body during pregnancy and after birth, and how it affects the mother, the developing baby, and breast milk. Researchers will collect data from pregnant people with CF who are taking or may take these medicines and measure drug levels over time. The goal is to learn dosing and safety information to keep mothers healthy while protecting infants. The project builds on prior findings showing wide differences between individuals, indicating personalized care could be important.
Why it matters
Potential benefit: If successful, the study could guide safer, more effective dosing of CFTR modulators during pregnancy and lactation, improving outcomes for both mothers and babies.
How similar studies have gone: Previous work has identified variable drug levels in individuals taking modulators, suggesting that personalized dosing could help.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Guimbellot, Jennifer S — Arkansas Children's Hospital Res Inst
- Study coordinator: Guimbellot, Jennifer S
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.