Pseudomonas phage: a new angle to treat chronic lung infections in cystic fibrosis
Official title: The Impact of a Pseudomonas Bacteriophage on Chronic Biofilm Lung Infections in Cystic Fibrosis
Funded at Stanford University · NIH-11400318 · Data updated 2026-11-12
A researcher at Stanford is studying how a virus that infects Pseudomonas bacteria (Pf phage) may help us understand and fight chronic lung infections in people with cystic fibrosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $192,672 |
| NIH project number | 5K08AI190313-02 |
| Project ID | NIH-11400318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with cystic fibrosis who suffer from chronic Pseudomonas aeruginosa lung infections.
✕Less likely to help
If you do not have cystic fibrosis or do not have chronic Pseudomonas infections, this study may not directly benefit you.
What this research studies
In people with cystic fibrosis, chronic lung infections from Pseudomonas aeruginosa are a major problem. This work investigates whether Pf bacteriophage helps the bacteria acquire iron, which could fuel persistent infection and disease progression. The project will explore how Pf phage binds and moves iron inside bacteria and how that affects bacterial growth and virulence. It also aims to see how Pf phage–driven iron uptake influences interactions with other bacteria like Staphylococcus aureus. Findings could point to new ways to disrupt chronic infections and improve outcomes for pwCF.
Why it matters
Potential benefit: If successful, the research could reveal a novel target to reduce chronic Pseudomonas infections in cystic fibrosis patients and improve lung health.
How similar studies have gone: Preliminary data suggest Pf phage binds iron and may influence bacterial growth, indicating a promising but still emerging approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Khosravi, Arya — Stanford University
- Study coordinator: Khosravi, Arya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.