Examining hormonal responses to meals in cystic fibrosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how individuals with cystic fibrosis respond hormonally to a mixed meal. It aims to identify correlations between these hormonal responses and impaired glucose tolerance, a common issue in this population. The study focuses on the role of pancreatic hormones, including insulin, glucagon, and somatostatin, in regulating glucose metabolism after eating. Participants will be monitored for their hormonal responses following a mixed meal to better understand the metabolic challenges faced by those with cystic fibrosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with cystic fibrosis
* Aged 18 to 45 years
* Males and females of any race and ethnicity
* Receiving highly effective CFTR modular therapy

Exclusion Criteria:

* Transplant recipient
* Acute lung function decline or exacerbation within the last 3 months
* Use of systemic glucocorticoids
* Pregnancy
* Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor
* The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the responses to liquid mixed meal or make participation in the study dangerous to the individual
* People who are cognitively impaired
* People who do not speak English
* For CFRD patients, a daily insulin requirement that exceeds 0.8 U/kg/day
* Any prior history of diabetic ketoacidosis.

Where it's running

• University of Cincinnati
  Cincinnati, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jason Winnick, PhD — University of Cincinnati
• Study coordinator: Jason Winnick, PhD
• Email: jason.winnick@uc.edu
• Phone: 513-558-4437

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.