Condition
Chronic Disease clinical trials and research
As of November 12, 2026, Find a Trial lists 42 Chronic Disease clinical trials that are recruiting, at sites in 16 countries (most in United States (13), China (6), France (5)). The most active sponsors are RIVER Foundation (2), National Health Research Institutes, Taiwan (2). There are also 49 NIH-funded research projects on Chronic Disease, with $61.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 42Clinical trials
- 49NIH research projects
- 16Countries
Newest Chronic Disease clinical trials
All recruiting trials (42)
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AI-powered personalized heat risk alerts for adults with chronic conditions
A smartphone app-based test will see if AI-driven, personalized heat risk alerts reduce heat-related illness symptoms in adults with chronic diseases.
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Mobile reminder app to help people with chronic disease and memory loss stick to their meds
This study tests whether a smartphone reminder app can improve how well adults with chronic diseases and memory impairment take their prescribed medications.
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Long-term health study of vascular and liver risk factors in Lishui
This study follows 4,500 adults in Lishui to see how screening and follow-up for stroke and related conditions might help prevent major diseases over time.
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Using smartwatches, hearing tests, and health records to predict disease risk in adults
This project will try to see if combining smartwatch data, hearing tests, questionnaires, and health records can predict future disease risk for adults living in Taiwan.
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Using Native Hawaiian cultural values to strengthen youth resilience, health, and well-being
This project will try a community referral program that connects Native Hawaiian and Pacific Islander youth ages 12–25 to culture-based Kaiona programs to see if it improves mental health and chronic conditions like asthma and obesity.
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Adapted Physical Activity Coaching for Chronic Disease Patients
This trial tests whether different lengths of adapted physical activity coaching, with or without a smartwatch, help adults with chronic diseases improve physical fitness and related behaviors.
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Family Good Health Traditions for Life program
This program will try a community-tailored, family-based version of the Diabetes Prevention Program to help Black parents with prediabetes and their children lower weight and reduce diabetes risk.
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Click & Pick: online shopping policies to help people choose healthier foods
This project will test whether adding taxes, front-of-pack warning labels, and healthy checkout rules on online grocery and restaurant sites helps lower-income adults buy and eat fewer ultra-processed foods.
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A six-week online self-management program for adults in Israel with chronic conditions
This six-week online group program will try to help adults in Israel who have chronic conditions—such as cancer survivors or kidney transplant recipients—learn practical skills to manage symptoms and daily health.
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Exercises to Improve Lower-Leg Blood Flow and Wound Healing
This program will test whether a tailored exercise system can improve lower-leg circulation and help chronic wounds in older adults with poor peripheral blood flow.
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Taining Golden Lake comprehensive chronic disease management program
This project will build a large cohort of adults in Taining County to collect health data and try to create a county-level chronic disease management model for people with hypertension, diabetes, dyslipidemia, and other long-term conditions.
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Lyophilized Vero-cell Rabies Vaccine in Immunocompromised, Chronic Disease, and Elderly Patients
This project tests whether a freeze-dried Vero-cell rabies vaccine produces protective antibody responses and is safe in people exposed to rabies who are elderly, have chronic diseases, or are non-HIV immunocompromised.
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Barriers to adopting a vegetarian diet in urban adults with chronic disease
See how open urban adults with chronic disease are to trying a vegetarian diet and what stops them.
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Effects of inpatient traditional, complementary and integrative medicine (TCIM) care in Germany.
This project will see if a routine package of inpatient TCIM therapies—like hyperthermia, exercise, mind‑body medicine, herbal and nutritional therapies including fasting—helps adults with chronic diseases admitted to participating German hospitals.
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Observational study on Vitamin C Injektopas® for vitamin C deficiency
This study is testing how well Vitamin C Injektopas® helps people with vitamin C deficiency feel better over time and if they can handle the treatment.
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Digital twin system for predicting outcomes in chronic diseases
This study is testing a new digital tool that simulates treatments to see if it can accurately predict health outcomes for people with chronic diseases.
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Bridges to Better Health and Wellness for Puerto Rico’s Serious Mental Illness
A culturally tailored program with monthly health care manager visits to help people with serious mental illness in Puerto Rico see if better primary care and reduced stigma can lower chronic disease risk.
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Helping newcomer families in Hamilton access physical activity resources
This study is testing whether giving newcomer families in Hamilton better access to physical activities can help their kids aged 5 to 11 feel more confident and active over time.
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Improve how patients stick to their treatments with a simple, standard message from healthcare professionals
A team delivers a brief, three-point message during visits to help adults with chronic illnesses better follow their treatment plan.
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CHIME: Comparing approaches to support healthy pregnancy and postpartum weight
This trial will try two different support programs versus usual care to see if they help pregnant people from early pregnancy through one year after birth keep a healthier weight.
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Training community members to be HealthyLifetime health coaches
This trial will test whether community members trained as health coaches can do as well as nurse health coaches at delivering the HealthyLifetime virtual program to adults without complex chronic conditions.
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Internet-based occupational therapy for managing chronic diseases
This study is testing a new online occupational therapy program to see if it can help people with chronic diseases manage their daily activities better.
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Evaluation of a pilot program for managing chronic diseases in Hong Kong
This study is testing a new program to see if it can help people aged 45 and older in Hong Kong manage their high blood pressure and diabetes better.
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Helping older adults manage chronic diseases after incarceration
This study is trying to help older adults who have just been released from prison manage their chronic diseases better by creating a special program just for them.
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Observational study on chronic diseases in Fujian Province
This study looks at how things like the environment, diet, and lifestyle affect the risk of heart and metabolic diseases in people aged 35 to 75 living in Fujian Province, China.
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Home use of ketamine for chronic conditions
This study is testing whether taking ketamine at home can help people with chronic pain, depression, or PTSD feel better and improve their symptoms.
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Evaluating Ketamine Treatment Plans for Chronic Conditions
This study is testing different ways to use Ketamine for people with chronic pain, depression, and anxiety to see how well it works and if combining it with therapies like talk therapy or music helps improve their conditions.
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Investigating gut microbiota in obese patients with type 2 diabetes and infections
This study looks at how the bacteria in the gut of obese adults with type 2 diabetes might affect their chances of getting chronic infections.
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A cohort study in Northern Spain to understand chronic diseases
This study is trying to learn more about chronic diseases by following 40,000-50,000 people aged 40-69 in Northern Spain over 20 years to see how their health and lifestyle affect their well-being.
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Integrating nursing care to enhance patient partnership in managing chronic diseases
This study is testing a new way for nurses to work with patients who have chronic diseases to create personalized care plans that help them manage their health better.
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Characterizing patients treated at internal medicine clinics
This study looks at patients with serious health issues treated in internal medicine clinics to see how their different conditions affect their care and to find better ways to diagnose and treat them.
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Focused Acceptance and Commitment Therapy for Parents of Children with Special Healthcare Needs
This study is trying out a video-based therapy program to see if it can help parents of children with special healthcare needs feel less stressed and improve their parenting during tough times.
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Analysis of glycosylation in lupus anti-DNA antibodies
This study looks at how certain sugars on antibodies in people with lupus might change over time and how those changes relate to their disease activity.
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Improving health for Black COVID-19 survivors and their caregivers
This study is testing a telehealth program to help Black COVID-19 survivors and their caregivers improve their health and manage chronic conditions better.
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Cohort study on Dampness Syndrome in Traditional Chinese Medicine
This study is looking at how Dampness Syndrome in Traditional Chinese Medicine might be linked to chronic diseases like diabetes, cancer, and dementia in people aged 35 to 75 over five years.
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Identifying vocal biomarkers to monitor chronic disease health
This study is trying to see if analyzing voice recordings can help track health changes in people with chronic diseases.
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Observational study on integrative medical care for chronic illnesses and mental health
This study is testing how a team approach to integrative medical care can help adults and children with chronic illnesses and mental health issues feel better.
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Analyzing sweat and saliva to detect chemical levels in patients with chronic or infectious diseases
This study is testing if new home methods for measuring medication levels in sweat and saliva can work as well as the standard lab tests for patients with chronic or infectious diseases.
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Improving medication management for elderly surgical patients
This study tests whether having a pharmacist and a doctor work together can help older surgical patients manage their medications more safely and effectively.
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Observational research on chronic diseases and healthcare analytics
This study looks at health records to see how well different treatments work for chronic diseases like HIV and hepatitis, aiming to improve patient care and support.
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Understanding health trends in Puerto Rico
This study is trying to understand health trends in Puerto Rico by looking at diet, mental health, and heart health in adults aged 30-75 over time.
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Collecting patient experiences and outcomes in hemophilia
This study is trying to collect and compare experiences and outcomes from people with hemophilia across different countries to better understand their needs and challenges over time.
NIH-funded research (newest 40 of 49)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Genomic risk tools to guide chronic disease care in adults
A program uses genetic risk scores along with health history to tailor prevention and early care for adults with chronic diseases.
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How Economic Tough Times Affect Health Habits in Older Adults with HIV
This study looks at how living with limited money changes how older adults with HIV take medicines and use preventive health services.
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Comprehensive food testing to prevent illness and protect health
This grant funds a program to test foods for dangerous chemicals and microbes to help keep people healthy and reduce chronic disease linked to food exposure.
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Understanding how multiple health problems cluster in aging people with HIV
This grant looks at how social factors and multiple health conditions come together to affect aging in people living with HIV.
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Arctic Ground Squirrels as a Model to Discover Treatments for Metabolic Diseases
Researchers are creating a new animal model using Arctic ground squirrels to uncover natural metabolic tricks that could lead to therapies for human conditions like diabetes and muscle wasting.
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Real-time sensor network to track inflammatory cytokines in chronic illness
This project develops tiny injectable sensors that continuously track inflammatory proteins to better understand and eventually help manage chronic conditions like autoimmune disease, cancer, and heart disease.
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Improving Chronic Disease Outcomes Across Lifespan by Tackling Structural Racism
This grant tests ways to reduce racial disparities in chronic disease outcomes by improving how social factors and discrimination affect care in healthcare settings.
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mHealth AI for Remote Heart and Lung Disease Detection
A mobile-phone based approach to predict heart and lung health measures so people in rural areas can get earlier, remote care.
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PAH exposure around reproductive windows linked to long-term disease risk
This study looks at how pollution from PAHs during pregnancy and other key reproductive periods might influence risks for heart disease and cancer later in life.
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Solar power and chronic disease care for older Puerto Ricans
This project looks at how access to solar power helps people 50 and older in Puerto Rico manage long-term conditions like diabetes, kidney, and lung disease.
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Advancing Chronic Disease Health Disparities at UH
A center at the University of Houston will accelerate research on chronic disease disparities by supporting basic, clinical, behavioral, and community science.
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How the right side of the heart works in health and long-term lung or heart disease
Seeing if stimulating a specific heart receptor can improve right-sided heart function for people with pulmonary hypertension or right heart failure.
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Validation and analysis of chronic disease data and biological samples
This study is all about looking at health information and samples from people with chronic diseases to help researchers understand these conditions better and improve future treatments.
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Minnesota Center for Reducing Chronic Diseases and Promoting Fair Health
This center works to improve the health of people across Minnesota by reducing chronic diseases and making sure everyone has fair access to health resources.
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A program to reduce chronic diseases and promote health equity in Minnesota.
This study is all about working with local communities in Minnesota to find and tackle health issues that affect people with chronic diseases, especially those who might not have easy access to care, so everyone can enjoy better health and support.
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Helping Black, Indigenous, and People of Color communities quit smoking to improve heart health
This project helps Black, Indigenous, and People of Color (BIPOC) adults who smoke connect with support to quit smoking and improve their heart health.
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Improving Health for Diverse Communities in Minnesota
This center works to reduce chronic diseases like heart disease, high blood pressure, and obesity in Black, Indigenous, and people of color (BIPOC) communities across Minnesota.
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Finding fair solutions to chronic disease disparities in the Southeast.
This study is all about finding better ways to help people in the Southeastern U.S. who have chronic diseases by working together with healthcare providers, community groups, and patients like you to tackle the challenges you face in getting care and improving your health.
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Understanding how COVID-19 care changes affected veterans with chronic conditions
This project looks at how changes in healthcare during the COVID-19 pandemic affected veterans with long-term health issues like heart disease, diabetes, and high blood pressure.
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Helping Latino Families Reduce Childhood Obesity and Chronic Disease Risk
This project explores a new way to help Latino children and their parents manage weight and lower the risk of chronic diseases like type 2 diabetes.
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Improving Health for People with Chronic Conditions by Addressing Systemic Barriers
This project helps healthcare systems better support adults and caregivers, especially those from racialized groups, by improving how social needs are met to improve chronic disease outcomes.
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Improving care for young adults with congenital heart disease and addressing health equity in pediatric care
This study is looking to improve healthcare for young adults with congenital heart disease as they move from children's to adult care, especially for those from diverse backgrounds or lower-income families, by training new researchers to help make healthcare fairer for everyone.
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Studying how cytokines signal in chronic diseases over time
This study is exploring how certain proteins in the body, called cytokines, affect long-lasting health issues, using a special sensor that can be injected to check these proteins in real-time, which could help us understand and improve treatments for chronic inflammation.
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How social stressors affect chronic disease in women
This study is looking at how tough life experiences and money worries can speed up aging and affect health in women, especially those who have faced trauma, to better understand how these challenges relate to conditions like PTSD, diabetes, and high blood pressure.
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Improving COVID-19 and flu vaccination rates among adults with chronic diseases in underserved communities
This study is testing a new way to help people from different racial and ethnic backgrounds with chronic illnesses get vaccinated for COVID-19 and the flu by using community health workers who provide personalized support and information.
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Collaboration to reduce chronic disease in Armenia through education on social factors
This study is all about helping people in Armenia live healthier lives by teaching them about things like smoking, drinking, and eating well, so they can make better choices and reduce the impact of chronic diseases in their communities.
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How solar energy can help manage chronic diseases in older Puerto Ricans during disasters
This study is looking at how using solar energy can help older Puerto Ricans with chronic health issues manage their conditions better, especially during power outages caused by natural disasters, and it aims to learn from their experiences to improve support and training in their communities.
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Improving chronic disease management for older adults in prisons
This study is looking at ways to help older adults in prison better manage their chronic health conditions by improving a program that teaches self-care skills, so they can feel healthier and more in control of their health.
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Improving care for patients with poorly controlled diabetes and hypertension through nurse-led telehealth.
This study is testing a new way to help people with diabetes and high blood pressure manage their health better by using phone and online support from nurses, so you can get the help you need anytime, anywhere!
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Improving communication between patients and doctors for older minority adults with chronic diseases
This study is testing a new tool called Photo+Care that helps older adults from minority backgrounds share their health experiences and challenges with their doctors, making it easier for them to manage multiple health conditions.
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Innovative solutions to reduce chronic disease disparities in the Southeast
This study is working to find better ways to help Black and Latino communities in the southeastern U.S. who are dealing with health issues like heart disease, diabetes, and asthma, by creating solutions that fit their specific needs and experiences.
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Reducing chronic disease disparities in BIPOC communities in Minnesota
This study is working to improve heart health for Black, Indigenous, and people of color in Minnesota by promoting healthier eating, exercise, and quitting smoking, while also exploring how racism affects health and training future researchers to help make things better.
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Reducing chronic disease disparities in BIPOC communities in Minnesota
This study is all about helping Black, Indigenous, and people of color in Minnesota live healthier lives by tackling issues like heart disease and obesity through community programs that encourage better eating, exercise, and quitting smoking, while also looking at how racism affects health.
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Improving self-management for patients with opioid use disorder and serious mental illness
This study is working on a program to help people with opioid use disorder and serious mental health issues learn to manage their health better, with support from their doctors and healthcare teams.
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Validation and analysis of chronic disease data and biological samples
This study is looking to better understand chronic diseases by analyzing medical records and biological samples from patients like you, helping to improve research and treatment for these conditions.
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Training program for preventing cardiovascular and chronic diseases
This program is designed to help scientists learn how to prevent heart and chronic diseases by working together on research that looks at both groups of people and individuals, focusing on fair health practices and including areas like nutrition and exercise.
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Improving tobacco cessation support for BIPOC communities to reduce heart disease
This study is looking for ways to better help Black, Indigenous, and People of Color (BIPOC) quit smoking, by offering personalized support from trained counselors, and it’s for adults in these communities who want to stop using tobacco and improve their heart health.
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Reducing chronic disease disparities in BIPOC communities in Minnesota
This study is working to help Black, Indigenous, and people of color in Minnesota live healthier lives by promoting better eating, more exercise, and quitting smoking, while also looking at how racism affects their health and finding ways to make things better together with the community.
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Finding solutions to health disparities affecting Black and Latino populations in the Southeast.
This study is looking for ways to help Black and Latino communities in the southeastern U.S. who are dealing with health issues like heart disease, diabetes, and asthma, by creating new programs that fit their specific needs and experiences.
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Helping Latino families tackle childhood obesity and chronic disease risk
This study is testing a new program that helps Latino parents learn how to make healthier choices for their overweight children, using online support to make it easier for families to join in and see if it works better than regular health education.
Related topics
Quick answers
How many Chronic Disease clinical trials are recruiting right now?
42, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 16 countries. The most sites are in United States (13 trials), China (6 trials), France (5 trials), Italy (2 trials), Hong Kong (2 trials). Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.