Analyzing sweat and saliva to detect chemical levels in patients with chronic or infectious diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational trial collects and analyzes sweat and saliva samples from patients with chronic or infectious diseases who are receiving medications. The study aims to compare the effectiveness of novel home-based methods for quantifying medication concentrations in these biofluids against the established gold standard of liquid chromatography-mass spectrometry of plasma. Participants will provide samples using a Macroduct Sweat Collection System and complete questionnaires, with follow-up assessments conducted periodically. The goal is to evaluate the feasibility and accuracy of using wearable sweat sensors for health monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Scheduled to receive medications including, but not limited to, cyclophosphamide, mycophenolic acid, mycophenolate mofetil, metformin or busulfan (any dose, any number of doses, any dosing frequency) as part of treatment at any time. Patients with chronic or infectious diseases can participate
* Willingness to:

  * Provide blood, sweat, and saliva samples
  * Permit medical record review

Exclusion Criteria:

* Pilocarpine allergy
* Difficulty with understanding written English

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting

Study contacts

• Principal investigator: Jeannine S McCune — City of Hope Medical Center

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.