Analyzing sweat and saliva to detect chemical levels in patients with chronic or infectious diseases
Pilot Study to Evaluate Substances in Sweat, Saliva, and Blood
This study is testing if new home methods for measuring medication levels in sweat and saliva can work as well as the standard lab tests for patients with chronic or infectious diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | City of Hope Medical Center Academic / other |
| Drugs / interventions | cyclophosphamide |
| Locations | 1 site (Duarte, California) |
| Trial ID | NCT04160429 on ClinicalTrials.gov |
What this trial studies
This observational trial collects and analyzes sweat and saliva samples from patients with chronic or infectious diseases who are receiving medications. The study aims to compare the effectiveness of novel home-based methods for quantifying medication concentrations in these biofluids against the established gold standard of liquid chromatography-mass spectrometry of plasma. Participants will provide samples using a Macroduct Sweat Collection System and complete questionnaires, with follow-up assessments conducted periodically. The goal is to evaluate the feasibility and accuracy of using wearable sweat sensors for health monitoring.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled to receive specific medications for chronic or infectious diseases.
Not a fit: Patients with pilocarpine allergies or those who have difficulty understanding written English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accessible and non-invasive methods for monitoring medication levels in patients.
How similar studies have performed: While the use of wearable sensors for health monitoring is an emerging field, this specific approach of comparing sweat and saliva analysis to plasma concentrations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled to receive medications including, but not limited to, cyclophosphamide, mycophenolic acid, mycophenolate mofetil, metformin or busulfan (any dose, any number of doses, any dosing frequency) as part of treatment at any time. Patients with chronic or infectious diseases can participate * Willingness to: * Provide blood, sweat, and saliva samples * Permit medical record review Exclusion Criteria: * Pilocarpine allergy * Difficulty with understanding written English
Where this trial is running
Duarte, California
- City of Hope Medical Center — Duarte, California, United States (Recruiting)
Study contacts
- Principal investigator: Jeannine S McCune — City of Hope Medical Center
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.