Exercises to Improve Lower-Leg Blood Flow and Wound Healing
Official title: Constructing a Holistic Care New Model for Chronic Wounds and Blood Circulation Detection to Enhance Home Care Quality
Run by National Health Research Institutes, Taiwan · NCT07330635 · Data updated 2026-11-12
This program will test whether a tailored exercise system can improve lower-leg circulation and help chronic wounds in older adults with poor peripheral blood flow.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 95 Years |
| Sex | All |
| Enrollment | 425 (estimated) |
| Sponsor | National Health Research Institutes, Taiwan Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | September 4, 2024 |
| Main results expected | September 4, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | January 9, 2026 |
| Trial ID | NCT07330635 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 65–95 with impaired peripheral circulation (for example from peripheral arterial disease, chronic venous insufficiency, diabetes, hypertension, or hyperlipidemia) who can perform basic physical activity and provide informed consent.
✕Probably not a fit
People who are too physically frail to perform exercise, have unstable medical conditions or acute limb-threatening events, or have severe cognitive impairment are unlikely to receive benefit from these interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional project develops a lower-limb circulation enhancement exercise system and compares three exercise approaches: a mixed exercise program, high-intensity rowing, and vibration exercise. The trial enrolls young healthy controls, healthy older adults (65–95), and older adults with chronic diseases that impair peripheral circulation. Outcomes include measures of lower-limb blood flow and functional performance, with exercises adapted for participants' frailty and ability. Participants must be able to perform basic physical activity and provide informed consent for in-person assessments.
Why it matters
Potential benefit: If successful, the program could improve leg blood flow, speed healing of chronic wounds, reduce reliance on medications, and improve mobility and quality of life for older adults.
How similar studies have gone: Prior research shows exercise programs can improve peripheral circulation and walking function in older adults, though high-intensity rowing and vibration approaches are less well studied in frail elderly populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: General criteria (applied to all participants): Willingness to participate in this study and comply with all study procedures. Able to perform basic physical activity and complete lower limb circulatory and functional assessments. Normal cognitive function sufficient to understand instructions and provide informed consent. Group-specific criteria: Young Adults (Control Group):Aged 20-40 years.No known chronic diseases or peripheral circulatory disorders.Considered healthy volunteers. Older Adults (Healthy Elderly Group):Aged 65-95 years.No major chronic diseases affecting lower limb circulation. Older Adults with Chronic Disease (Impaired Circulation Group):Aged 65-95 years.Diagnosed with one or more conditions known to impair peripheral circulation, including but not limited to peripheral arterial disease (e.g., atherosclerosis, thromboangiitis obliterans), chronic venous insufficiency (e.g., varicose veins), diabetes mellitus, hypertension, or hyperlipidemia. Exclusion Criteria: Recent acute lower limb injury resulting in tissue exudation, swelling, or other conditions that prevent safe participation in the assessment or intervention procedures.
Where it's running
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National Center for Geriatrics and Welfare Research, National Health Research Institutes
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Po-Jung Chen, Ph.D.
- Email: pojungchen@nhri.edu.tw
- Phone: +886-5-632-5080
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.