Context-specific pathway dependencies for nuclear envelope proteins in brain cancer
Funded at Dana-Farber Cancer Inst · NIH-11366260 · Data updated 2026-11-12
This grant explores how nuclear envelope proteins influence brain cancer behavior using cancer cell models to map signaling and functional networks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $718,275 |
| NIH project number | 1R01CA303334-01A1 |
| Project ID | NIH-11366260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation in this stage of the project; uses cancer cell lines and computational analyses.
✕Less likely to help
No direct patient involvement or benefits at this stage.
What this research studies
Researchers will study how nuclear envelope proteins act differently across brain cancer cell lines, using advanced analyses to separate distinct functions of these proteins. They will apply a framework called Webster to identify context-specific roles in cancer cells and highlight which cellular contexts are most relevant for particular protein functions. The project will leverage large-scale cancer cell line data to link nuclear envelope biology to disease-specific phenotypes in brain tumors. The work aims to clarify how mutations in nuclear envelope genes contribute to brain cancer complexity and potential therapeutic angles.
Why it matters
Potential benefit: If successful, it could clarify disease mechanisms in brain cancer and guide future targeted therapies.
How similar studies have gone: Previous research using large cancer cell line datasets has begun to map functional networks, with growing evidence that context matters for gene effects.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Hahn, William C. — Dana-Farber Cancer Inst
- Study coordinator: Hahn, William C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.