Brain cancer therapies to help kids and adults with glioblastoma and medulloblastoma
Official title: SPORE in Brain Cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-11404894 · Data updated 2026-11-12
A large NIH grant supports translating promising brain cancer therapies from the lab into patient trials to help people with glioblastoma and medulloblastoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2008 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,282,530 |
| NIH project number | 5P50CA127001-18 |
| Project ID | NIH-11404894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with glioblastoma or medulloblastoma who are eligible for early-phase or translational clinical trials.
✕Less likely to help
Some patients may not respond to these experimental therapies or may not meet trial criteria.
What this research studies
This grant funds a multi-year, team-based program at MD Anderson to develop and test therapies that target brain cancers more precisely and safely. Researchers work from bed- to-bench and back, moving promising ideas into early clinical trials and learning from each result to improve approaches. The effort includes bio-therapies, targeted drugs, cellular therapies, and immunotherapies, with several trials already completed or underway. The goal is to extend survival and improve quality of life for patients of all ages affected by GBM and MB.
Why it matters
Potential benefit: If successful, patients could receive more effective, personalized treatments with fewer side effects and longer survival.
How similar studies have gone: Past work in this program has translated several agents from the lab to clinical trials with encouraging safety and early efficacy signals.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lang, Frederick F — University of Tx Md Anderson Can Ctr
- Study coordinator: Lang, Frederick F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.