Multi-parametric perfusion MRI to predict brain cancer therapy response
Official title: Multi-parametric Perfusion MRI for Therapy Response Assessment in Brain Cancer
Funded at St. Joseph's Hospital and Medical Center · NIH-11361637 · Data updated 2026-11-12
A study to improve brain cancer care by using advanced MRI techniques to predict early how tumors respond to treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $496,204 |
| NIH project number | 5UH3CA247606-05 |
| Project ID | NIH-11361637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with brain tumors who undergo MRI-based therapy monitoring.
✕Less likely to help
Patients who cannot undergo MRI or have contraindications to contrast agents may not benefit.
What this research studies
This project will refine and test quantitative MRI methods that measure tumor perfusion and permeability, aiming to predict therapy response earlier than current standards. Researchers will focus on standardizing imaging protocols, reducing variability across sites, and automating analysis to make DSC- and DCE-MRI more reliable in clinical practice. By addressing these gaps, the work could help doctors tailor treatments and avoid unnecessary procedures for patients with brain cancer.
Why it matters
Potential benefit: If successful, this work could lead to faster, more accurate predictions of treatment response, guiding better treatment decisions for brain cancer patients.
How similar studies have gone: Prior DSC/DCE-MMRI studies show promise, but lack of standardization has limited clinical adoption.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Stokes, Ashley M — St. Joseph's Hospital and Medical Center
- Study coordinator: Stokes, Ashley M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.