Exploring the impact of anesthesia on brain cancer survival

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of different types of anesthesia on the survival of patients undergoing surgery for high-grade gliomas, specifically glioblastoma multiforme. Patients will be assigned to receive either propofol or sevoflurane during their elective craniotomy procedures. The study aims to determine if the choice of anesthetic can influence cancer progression and patient outcomes. By examining this relationship, the researchers hope to identify potential factors that could improve survival rates in patients with aggressive brain tumors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient presenting between Jul 1, 2022 and Dec 28, 2023 for elective procedure
2. Males or females of \>18 years
3. Patient will be undergoing primary craniotomy (with general anesthesia) for suspected high-grade primary glial brain tumor (WHO grade III and IV)

Exclusion Criteria:

1. Patients of pediatric age group and pregnant patients
2. Patients previously diagnosed with severe adrenal dysfunction (over activity or insufficiency)
3. Suspected low grade (grade I, II), glioma, tumors involving brainstem and optic tract, and as well as non-glial tumors (i.e. suspected brain metastasis)
4. Awake craniotomies
5. Any conditions that preclude postoperative MRI
6. Motor evoked potential monitoring or any other intraoperative condition that renders choice of anesthetics affected.
7. Recurrent GBM

Where it's running

• Toronto Western Hospital/UHN
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Tumul Chowdhury, MD — University Health Network, Toronto
• Study coordinator: Emad Al Azazi, MD
• Email: emad.alazazi@uhn.ca
• Phone: 416-603-5800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.