Exploring the impact of anesthesia on brain cancer survival
Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study
NA · University Health Network, Toronto · NCT04962672
This study is testing whether using different types of anesthesia during brain surgery can help improve survival for patients with aggressive brain cancer.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Health Network, Toronto (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT04962672 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of different types of anesthesia on the survival of patients undergoing surgery for high-grade gliomas, specifically glioblastoma multiforme. Patients will be assigned to receive either propofol or sevoflurane during their elective craniotomy procedures. The study aims to determine if the choice of anesthetic can influence cancer progression and patient outcomes. By examining this relationship, the researchers hope to identify potential factors that could improve survival rates in patients with aggressive brain tumors.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are scheduled for elective craniotomy for suspected high-grade primary glial brain tumors.
Not a fit: Patients with low-grade gliomas, non-glial tumors, or those requiring awake craniotomies will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates for patients with high-grade gliomas by optimizing anesthesia protocols.
How similar studies have performed: While some studies have suggested a link between anesthesia type and cancer progression in other solid tumors, this specific approach to gliomas is relatively novel and underexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient presenting between Jul 1, 2022 and Dec 28, 2023 for elective procedure 2. Males or females of \>18 years 3. Patient will be undergoing primary craniotomy (with general anesthesia) for suspected high-grade primary glial brain tumor (WHO grade III and IV) Exclusion Criteria: 1. Patients of pediatric age group and pregnant patients 2. Patients previously diagnosed with severe adrenal dysfunction (over activity or insufficiency) 3. Suspected low grade (grade I, II), glioma, tumors involving brainstem and optic tract, and as well as non-glial tumors (i.e. suspected brain metastasis) 4. Awake craniotomies 5. Any conditions that preclude postoperative MRI 6. Motor evoked potential monitoring or any other intraoperative condition that renders choice of anesthetics affected. 7. Recurrent GBM
Where this trial is running
Toronto, Ontario
- Toronto Western Hospital/UHN — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Tumul Chowdhury, MD — University Health Network, Toronto
- Study coordinator: Emad Al Azazi, MD
- Email: emad.alazazi@uhn.ca
- Phone: 416-603-5800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Anesthesia, Brain Cancer, Survival