Understanding how immune cells affect brain cancer treatment
Metabolic and molecular regulation of myeloid cell functions in brain cancer
This study is looking at how certain immune cells in the brain, called macrophages, behave in glioblastoma, a tough type of brain cancer, to find new ways to make treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11194004 on NIH RePORTER |
What this research studies
This research investigates the role of tumor-associated macrophages in glioblastoma, the most aggressive form of brain cancer. It aims to uncover the metabolic and molecular mechanisms that regulate these immune cells, which contribute to the cancer's immunosuppressive environment. By studying how these macrophages adapt their metabolism, particularly their use of glucose, the research seeks to identify new therapeutic targets that could enhance the effectiveness of immunotherapies for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting immune cell functions in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Veglia, Filippo — Wistar Institute
- Study coordinator: Veglia, Filippo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.