Understanding how immune cells affect brain cancer treatment
Official title: Metabolic and molecular regulation of myeloid cell functions in brain cancer
Funded at Wistar Institute · NIH-11194004 · Data updated 2026-11-12
This study is looking at how certain immune cells in the brain, called macrophages, behave in glioblastoma, a tough type of brain cancer, to find new ways to make treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $426,379 |
| NIH project number | 5R01NS131912-03 |
| Project ID | NIH-11194004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the role of tumor-associated macrophages in glioblastoma, the most aggressive form of brain cancer. It aims to uncover the metabolic and molecular mechanisms that regulate these immune cells, which contribute to the cancer's immunosuppressive environment. By studying how these macrophages adapt their metabolism, particularly their use of glucose, the research seeks to identify new therapeutic targets that could enhance the effectiveness of immunotherapies for patients with glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting immune cell functions in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Wistar Institute
Philadelphia, United States Active
Researchers
- Principal investigator: Veglia, Filippo — Wistar Institute
- Study coordinator: Veglia, Filippo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.