Proteins that stick to amyloid plaques in Alzheimer's
Amyloidosis associated proteins in Alzheimer’s disease pathogenesis
The team is looking at whether extra proteins that collect with amyloid plaques help cause brain injury in people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11169687 on NIH RePORTER |
What this research studies
This work uses detailed protein studies of human Alzheimer's brain samples and mouse models to find proteins that accumulate with amyloid-beta plaques. The researchers will combine large public proteomics datasets (like AMP-AD) with laboratory experiments in mice and molecular analyses to see which amyloid-associated proteins (AAPs) are linked to nerve-cell loss. They aim to explain why amyloid buildup can exist for years before neurodegeneration starts by testing whether AAPs help trigger the damage. The findings will guide which proteins might become targets for future tests or treatments.
Who could benefit from this research
Good fit: People with Alzheimer's disease—especially those with early-stage disease or evidence of amyloid buildup—are the group most relevant to this research.
Not a fit: People without Alzheimer's or those with non-amyloid forms of dementia are unlikely to get direct benefit from this specific line of work.
Why it matters
Potential benefit: If true, this could identify new targets to stop or slow the brain damage that leads to dementia in Alzheimer's.
How similar studies have performed: Proteomics has already found many proteins in amyloid plaques, but linking specific plaque-associated proteins to downstream neurodegeneration is a relatively new and active area of research.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Prokop, Stefan — University of Florida
- Study coordinator: Prokop, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.