Investigating the role of Y chromosome loss in heart disease related to amyloidosis
Mosaic Loss of the Y Chromosome in Cardiac Amyloidosis
This study is looking into how losing the Y chromosome in blood cells might be linked to a heart condition called transthyretin cardiac amyloidosis, especially in men, to help find better ways to diagnose and treat this serious issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11065545 on NIH RePORTER |
What this research studies
This research focuses on understanding how the loss of the Y chromosome in blood cells may contribute to a serious heart condition known as transthyretin cardiac amyloidosis (ATTR). The study aims to explore the relationship between this genetic change and the development of heart failure, particularly in men, who are disproportionately affected by this disease. By examining patient samples and using animal models, researchers will investigate the mechanisms behind this condition and how it may be diagnosed and treated more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with transthyretin cardiac amyloidosis or those at risk for this condition.
Not a fit: Patients who are female or do not have transthyretin cardiac amyloidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from cardiac amyloidosis.
How similar studies have performed: Previous research has shown promising results linking Y chromosome loss to cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Walsh, Kenneth — University of Virginia
- Study coordinator: Walsh, Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.