Condition

Smoldering Multiple Myeloma clinical trials and research

• 15Clinical trials
• 2NIH research projects
• 16Countries

Newest Smoldering Multiple Myeloma clinical trials

All recruiting trials (15)

• Prolonged overnight fasting combined with a Mediterranean-style diet for people with multiple myeloma or precursor conditions

  This program will test whether longer overnight fasting paired with a Mediterranean-style eating plan is doable for adults with MGUS, smoldering myeloma, or newly diagnosed multiple myeloma who are starting treatment.

  Recruiting University of Miami · Miami, Florida · NCT07446777

• Using Whole Body MRI to Improve Cancer Detection

  This study is testing if Whole Body MRI can help find bone and soft tissue problems in people with different types of cancer, like lymphoma and advanced prostate and breast cancer.

  Recruiting at 2 sites Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · Bologna, BO and 2 other locations · NCT06895291

• Combining JNJ-79635322 with Daratumumab or Pomalidomide for Multiple Myeloma Treatment

  This study is testing a new drug called JNJ-79635322 combined with either daratumumab or pomalidomide to see how safe and effective it is for people with multiple myeloma.

  Recruiting at 16 sites Phase 1 Janssen Research & Development, LLC · Denver, Colorado and 15 other locations · NCT06768489

• Network for early diagnosis and management of AL amyloidosis in Italy

  This study is trying to set up a network in Italy to help doctors find AL amyloidosis earlier in patients who are at risk, so they can get treatment sooner and improve their health.

  Recruiting at 4 sites Fondazione IRCCS Policlinico San Matteo di Pavia · Bari and 3 other locations · NCT06383143

• Screening for AL Amyloidosis in patients with Smoldering Multiple Myeloma

  This study is trying to find out if screening for a specific type of amyloidosis can help catch it early in patients with smoldering multiple myeloma before they show any symptoms.

  Recruiting at 12 sites Tufts Medical Center · Birmingham, Alabama and 12 other locations · NCT06365060

• Collection and analysis of biological samples from patients with multiple myeloma and related conditions

  This study is collecting and storing blood samples from patients with multiple myeloma and similar conditions to help researchers learn more about these diseases and improve treatments.

  Recruiting at 41 sites European Myeloma Network B.V. · Melbourne and 40 other locations · NCT06237803

• Observing high-risk smoldering myeloma patients for insights

  This study is trying to learn more about how high-risk smoldering myeloma changes over time by closely watching patients with this condition using special MRI scans.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06212323

• Vaccination with TG01/QS-21 for patients with high-risk smoldering multiple myeloma and multiple myeloma

  This study is testing a new vaccine to see if it can help people with high-risk smoldering multiple myeloma or multiple myeloma who have certain gene mutations feel better and live longer.

  Recruiting Phase 1/2 Oslo University Hospital · Oslo, Oslo · NCT05841550

• Comparing a plant-based diet with supplements and placebo for people with MGUS or smoldering multiple myeloma

  This study is testing whether a plant-based diet combined with certain supplements can change butyrate levels in people with MGUS or smoldering multiple myeloma.

  Recruiting at 8 sites Memorial Sloan Kettering Cancer Center · Atlanta, Georgia and 7 other locations · NCT05640843

• Using Selinexor to Treat High-Risk Smoldering Multiple Myeloma

  This study is testing if a low dose of selinexor can help people with high-risk smoldering multiple myeloma delay the progression to full-blown multiple myeloma.

  Recruiting Phase 2 University of Rochester · Rochester, New York · NCT05597345

• Testing Teclistamab for high-risk smoldering multiple myeloma

  This study is testing if Teclistamab can work better than a mix of Lenalidomide and Dexamethasone for people with high-risk smoldering multiple myeloma.

  Recruiting at 3 sites Phase 2 Dana-Farber Cancer Institute · Denver, Colorado and 2 other locations · NCT05469893

• Understanding different types of multiple myeloma precursor conditions

  This study is trying to tell the difference between two early stages of multiple myeloma, smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, to better understand how they progress or stay stable.

  Recruiting University of Miami · Miami, Florida · NCT05361694

• Cohort of patients with plasma cell disorders at Peking University First Hospital

  This study is looking at hospitalized patients with plasma cell disorders to see how their treatment and disease status affect their outcomes over time.

  Recruiting Peking University First Hospital · Beijing · NCT05283993

• Registry for adults with plasma cell disorders

  This study is creating a registry for adults with plasma cell disorders like multiple myeloma to track their health and care experiences over time while also collecting blood samples for future research.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT03717844

• Assessing molecular changes in blood cancers

  This study is trying to see how changes in blood samples from people with early blood cancers can help us understand their condition better and find new treatment options.

  Recruiting at 7 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 6 other locations · NCT02269592

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Checking for AL amyloidosis in people with smoldering myeloma

  This project will use blood markers and clinical data to find hidden AL amyloidosis early in people with smoldering multiple myeloma.

  NIH research Tufts Medical Center · Boston, United States · NIH-11294139

• Improving early diagnosis of AL amyloidosis in patients with smoldering multiple myeloma

  This study is looking to find a better way to spot early signs of AL amyloidosis in people with smoldering multiple myeloma, so we can help them avoid serious health issues like heart and kidney problems.

  NIH research Tufts Medical Center · Boston, United States · NIH-11044135

Related topics

Quick answers

How many Smoldering Multiple Myeloma clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (10 trials), Italy (3 trials), Australia (2 trials), Israel (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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