Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers
Official title: IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELE
Funded at Ut Southwestern Medical Center · NIH-11393304 · Data updated 2026-11-12
This project looks for early signs of heart damage in Black individuals who carry the V122I TTR variant and may benefit from new treatments if caught early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $692,660 |
| NIH project number | 5R01HL160892-05 |
| Project ID | NIH-11393304 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are Black adults who carry the V122I TTR variant and are asymptomatic or have no overt cardiac symptoms.
✕Less likely to help
Individuals who do not carry the V122I TTR variant or who already have diagnosed advanced heart disease may not benefit from this specific screening approach.
What this research studies
We will study Black adults who carry the V122I TTR gene variant to see if there are early, subclinical signs of cardiac amyloidosis using imaging and biomarkers. The research will compare carriers to non-carriers to understand how the heart’s structure and function change before symptoms appear. By identifying specific biomarkers and MRI findings, doctors could diagnose hATTR-CA earlier and start therapies sooner. The study will combine imaging data, blood tests, and clinical information to map the progression from carrier status to subclinical disease.
Why it matters
Potential benefit: If successful, the work could lead to earlier detection and treatment of hereditary cardiac amyloidosis in Black patients carrying the V122I TTR variant.
How similar studies have gone: Preliminary work suggests subclinical amyloid changes can be detected with imaging and biomarkers in carriers, supporting further study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Grodin, Justin Lee — Ut Southwestern Medical Center
- Study coordinator: Grodin, Justin Lee
Related research
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The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.
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Improving outcomes in cardiac amyloidosis using innovative imaging techniques
This study is looking at new ways to use advanced imaging to improve how we diagnose and treat cardiac amyloidosis, helping doctors create personalized care plans for patients while also training future researchers in this important area.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.