Understanding the structure of tau proteins linked to Alzheimer's and related diseases
Official title: Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosis
Funded at Indiana University Indianapolis · NIH-11081779 · Data updated 2026-11-12
This study is looking at how tau proteins in the brain clump together and cause problems in diseases like Alzheimer's, with the goal of finding new ways to diagnose and treat these conditions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $725,441 |
| NIH project number | 5R01AG071177-03 |
| Project ID | NIH-11081779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related tauopathies, particularly those with specific genetic mutations linked to tau aggregation.
✕Less likely to help
Patients with neurodegenerative diseases not associated with tau protein aggregation may not benefit from this research.
What this research studies
This research investigates the atomic structures of tau proteins that aggregate in the brain and contribute to neurodegenerative diseases like Alzheimer's. Using advanced techniques such as cryo-electron microscopy, the team aims to uncover how these tau aggregates form and their role in diseases characterized by abnormal protein deposits. The project also explores the effects of various modifications on tau proteins and how they influence disease progression. By understanding these mechanisms, the research seeks to pave the way for new diagnostic and therapeutic strategies for patients affected by these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for Alzheimer's disease and related neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding tau protein structures and their implications in neurodegenerative diseases, indicating a strong foundation for this ongoing investigation.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Vidal, Ruben — Indiana University Indianapolis
- Study coordinator: Vidal, Ruben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.