Condition

Cardiac Amyloidosis clinical trials and research

• 29Clinical trials
• 14NIH research projects
• 14Countries

Newest Cardiac Amyloidosis clinical trials

All recruiting trials (29)

• Liver and Coagulation Markers in ATTR Cardiac Amyloidosis

  This study tests liver function and blood-clotting markers in people with ATTR-CA to see if they reflect disease severity and progression.

  Recruiting University of Messina · Messina, Sicily · NCT07766135

• Cardiac Amyloidosis: See if Intracardiac Thrombi are Common on CT

  This study tests whether a contrast-enhanced cardiac CT can reliably detect intracardiac thrombi in adults with cardiac amyloidosis.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT07648303

• Higher pacemaker rate for people with cardiac amyloidosis

  This study will see if temporarily increasing the pacemaker rate improves heart-failure symptoms and exercise tolerance in adults with cardiac amyloidosis who already have pacemakers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07583823

• Using [64Cu]FBP8 PET/MR to find intracardiac blood clots in cardiac amyloidosis

  We'll test whether a [64Cu]FBP8 PET/MR scan can find blood clots inside the heart of people with cardiac amyloidosis who have atrial fibrillation or atrial flutter.

  Recruiting Phase 3 Brigham and Women's Hospital · Boston, Massachusetts · NCT07560306

• Chest pain screening for hidden cardiac amyloidosis

  We will test whether men over 65 who have chest pain but no coronary artery disease might have hidden cardiac amyloidosis using blood and urine tests, ECG and echocardiography, bone scintigraphy, and sometimes a heart biopsy.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07435168

• Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies

  This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07336394

• Deep learning to analyze and track echocardiograms

  This project will test AI tools that help clinicians read echocardiograms and flag adults who may have genetic cardiomyopathy, ischemic heart disease, or cardiac amyloidosis to see if interpretation improves and diagnoses happen faster.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07308704

• 18F‑FT8 PET imaging for light‑chain (AL) cardiac amyloidosis

  This project tests whether a new PET tracer, 18F‑FT8, can safely and clearly image light‑chain (AL) cardiac amyloidosis in adults with suspected or known disease and in healthy volunteers.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07232459

• US benchmarking of heart and liver stiffness using shear wave ultrasound

  This project will test whether a new ultrasound device can measure heart and liver stiffness using shear wave velocity in people aged 60 or older with preserved or mildly reduced ejection fraction and left ventricular hypertrophy, with or without transthyretin amyloid cardiomyopathy, and in control subjects.

  Recruiting at 3 sites eMyosound SAS · Boston, Massachusetts and 2 other locations · NCT07215715

• Amyloid deposits in the heart and heart function in people with Alzheimer's disease

  This project will see if the same amyloid buildup found in Alzheimer's also shows up in the heart by adding a heart amyloid PET/MRI, an echocardiogram, and a dementia exam for people already having a brain amyloid PET.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07154394

• Hybrid 18F-Florbetaben PET/MRI to image cardiac amyloidosis

  This trial will test whether a combined 18F-Florbetaben PET and MRI scan can find imaging signs that predict major heart events in people with cardiac amyloidosis.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07154381

• Pan-amyloid PET/CT scans to find amyloid deposits in adults

  This project tests whether PET/CT scans using amyloid tracers can find amyloid deposits in adults with suspected or known amyloidosis, including heart involvement.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07130565

• Understanding patients with transthyretin cardiac amyloidosis

  This study looks at patients with transthyretin cardiac amyloidosis to learn more about how the disease affects their hearts and overall health over time.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06907836

• Registry for patients with cardiac amyloidosis

  This study is collecting information from adults with cardiac amyloidosis to see how the disease progresses and to help improve treatment and care for patients.

  Recruiting at 6 sites Leiden University Medical Center · Bruges and 5 other locations · NCT06894290

• Assessing exercise capacity and prognosis in patients with cardiac amyloidosis

  This study is testing how well people with cardiac amyloidosis can exercise and what that means for their health over two years.

  Recruiting Centro Cardiologico Monzino · Milan, Italy · NCT06799273

• Study of heart conditions using advanced imaging techniques

  This study is trying to find out what causes different heart conditions in Hispanic and African American people in the Bronx by using advanced imaging techniques.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06610019

• Diagnosing ATTR Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome

  This study is testing if patients with carpal tunnel syndrome might also have a heart condition called ATTR amyloidosis by doing tests and following them for 10 years.

  Recruiting Helse Møre og Romsdal HF · Ålesund, Møre og Romsdal · NCT06458374

• Prevalence of cardiac amyloidosis in older patients with heart failure

  This study looks at how common cardiac amyloidosis is in older patients over 80 who have been hospitalized for heart failure with thickened heart muscles.

  Recruiting at 35 sites Gérond'if · Paris, IIe-de-France and 35 other locations · NCT06427304

• Effects of Shiatsu on Symptoms and Quality of Life in Cardiac Amyloidosis Patients

  This study is testing whether three special Shiatsu massage sessions can help improve symptoms and quality of life for people with severe cardiac amyloidosis compared to regular comfort Shiatsu or no massage at all.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06197165

• Registry for patients with cardiac amyloidosis at University Hospital Leipzig

  This study is collecting information from patients with cardiac amyloidosis at University Hospital Leipzig to better understand the disease and improve treatment and care.

  Recruiting University of Leipzig · Leipzig, Saxony · NCT06129656

• Exercise program for patients with cardiac amyloidosis

  This study tests whether a supervised exercise program can help people with cardiac amyloidosis and heart failure feel better and improve their heart health.

  Recruiting Wake Forest University Health Sciences · Charlotte, North Carolina · NCT06096675

• Identifying cardiac amyloidosis in older adults with lumbar spinal stenosis

  This study is trying to find out if older adults who have had surgery for lumbar spinal stenosis also have a heart condition called transthyretin cardiac amyloidosis by looking at their spinal tissue and using advanced technology.

  Recruiting at 5 sites Columbia University · Beverly Hills, California and 5 other locations · NCT06034405

• Echocardiographic evaluation of cardiac amyloidosis

  This study is testing new heart imaging techniques to see if they can help tell cardiac amyloidosis apart from other heart problems and check how well tafamidis treatment can improve heart damage in patients.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT05760287

• Registry for cardiac PYP scans in patients with heart failure and amyloidosis in Taiwan

  This study is collecting and analyzing data from patients in Taiwan with heart failure and suspected cardiac amyloidosis to see if PYP scans can help diagnose the condition better than traditional methods.

  Recruiting Far Eastern Memorial Hospital · New Taipei City · NCT05593679

• AI-guided echocardiogram screening for cardiac amyloidosis

  This study is testing whether an AI tool can help doctors find people at high risk for cardiac amyloidosis by analyzing heart ultrasound images more accurately.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT05139797

• Healthcare European Amyloidosis Registry

  This study is collecting information from patients with cardiac amyloidosis to better understand how the disease affects them over time without changing their treatment.

  Recruiting Saving Lives Matters · Créteil · NCT05101304

• Preventing hospital admission for ATTR cardiomyopathy with home telemonitoring

  This will test whether a home telemonitoring service using daily weight scales can reduce hospital admissions for adults with ATTR cardiac amyloidosis.

  Recruiting Richmond Pharmacology Limited · London, London · NCT05098665

• Evaluating amyloid burden in cardiac amyloidosis using bone scintigraphy

  This study is testing a new way to measure amyloid buildup in the hearts of people with transthyretin cardiac amyloidosis to see if it can help doctors better track the disease and improve treatment outcomes.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lille · NCT04849754

• Assessing microvascular function in patients with cardiac amyloidosis

  This study is testing how well the tiny blood vessels in the hearts of people with cardiac amyloidosis are working to see if it can help understand their condition better.

  Recruiting Samsung Medical Center · Seoul · NCT02798705

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers

  This project looks for early signs of heart damage in Black individuals who carry the V122I TTR variant and may benefit from new treatments if caught early.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11393304

• Chip phosphorylation boosts breakdown of mutant TTR to help heart amyloidosis

  A scientist-led project aims to help people with a heart disease caused by a mutant protein called transthyretin (TTR) by boosting the body’s protein-cleanup systems to remove the harmful TTR deposits.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11386483

• Finding transthyretin heart amyloid from lumbar spine surgery tissue

  This project looks for transthyretin (TTR) amyloid in tissue removed during lumbar spine surgery to find people who may later develop TTR cardiac amyloidosis.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11374113

• Blood biomarker test for heart amyloidosis in Black and Hispanic people

  A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11372835

• PET tracer to image cardiac amyloidosis

  A new PET tracer is being developed to help visualize amyloid buildup in the heart, potentially helping people with amyloidosis and related heart disease.

  NIH research Washington University · Saint Louis, United States · NIH-11368737

• Why losing parts of the Y chromosome may drive TTR heart amyloidosis in men

  The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.

  NIH research University of Virginia · Charlottesville, United States · NIH-11258520

• Improving outcomes in cardiac amyloidosis using innovative imaging techniques

  This study is looking at new ways to use advanced imaging to improve how we diagnose and treat cardiac amyloidosis, helping doctors create personalized care plans for patients while also training future researchers in this important area.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11127391

• Hidden transthyretin heart amyloid in people with the V122I gene

  This project looks for early signs of transthyretin-related heart amyloid in Black adults who carry the V122I gene change.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11095793

• Boosting CHIP to help clear mutant transthyretin from the heart

  Sees if turning on CHIP and a partner enzyme (PKG) helps heart cells and lab-grown heart tissue clear mutant transthyretin for people with transthyretin cardiac amyloidosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11082288

• Personalized exercise training to enhance physical ability in older adults with cardiac amyloidosis

  This study is looking to see if a special 12-week exercise program can help older adults with heart issues from cardiac transthyretin amyloidosis feel stronger and improve their overall quality of life.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11072081

• Investigating the role of Y chromosome loss in heart disease related to amyloidosis

  This study is looking into how losing the Y chromosome in blood cells might be linked to a heart condition called transthyretin cardiac amyloidosis, especially in men, to help find better ways to diagnose and treat this serious issue.

  NIH research University of Virginia · Charlottesville, United States · NIH-11065545

• Investigating how a protein can help reduce heart damage from a genetic mutation

  This study is looking at a heart condition called cardiac amyloidosis, which happens when a protein builds up in the heart, and it's testing a new way to help break down these harmful proteins using a special enzyme, with the hope of finding better treatments for patients like you.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10882087

• Identifying early signs of heart disease in certain Black individuals

  This study is looking for people with a specific genetic variant linked to hereditary cardiac amyloidosis to find early signs of heart issues using special imaging and blood tests, so they can get treatment sooner and improve their heart health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10871889

• Detecting heart issues caused by protein buildup in older adults

  This study is looking for early signs of a heart condition called transthyretin cardiac amyloidosis (ATTR-CA) in older adults, using special imaging to spot changes in the heart before any symptoms show up, so that treatment can start sooner and help manage heart health better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10569547

Related topics

Quick answers

How many Cardiac Amyloidosis clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (8 trials), France (6 trials), Italy (4 trials), China (3 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →