Am I ATTRisk? Genomic screening to find hereditary ATTR in African American and Hispanic/Latino adults
Official title: Am I ATTRisk? Health empowerment through population genomic screening for transthyretin amyloidosis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11279013 · Data updated 2026-11-12
A population-based genomic screening program aims to identify people with the hereditary transthyretin amyloidosis (ATTRv) risk so they can get timely monitoring and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $809,307 |
| NIH project number | 1R01HL183991-01 |
| Project ID | NIH-11279013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who identify as African American or Hispanic/Latino and are eligible for genomic screening.
✕Less likely to help
People who are not at elevated genetic risk for ATTRv or who choose not to undergo genetic testing may not benefit.
What this research studies
This project focuses on African American and Hispanic/Latino adults who carry genetic variants that increase their risk for ATTRv, a condition that can cause heart and nerve problems. The study plans to implement population-level genetic screening and ensure access to genetics experts, with culturally sensitive communication to help people understand and act on their results. By identifying carriers early, clinicians can monitor symptoms and start treatment sooner to prevent serious complications. The work will involve collaboration with Mount Sinai to enroll participants, share appropriate results, and link individuals to necessary follow-up care.
Why it matters
Potential benefit: If successful, it could lead to earlier detection and treatment of ATTRv in high-risk groups, improving heart and nerve health and reducing mortality.
How similar studies have gone: Genomic screening programs for other heritable conditions have shown promise in increasing early detection and preventive care.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Kontorovich, Amy R. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kontorovich, Amy R.
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-
Finding transthyretin heart amyloid from lumbar spine surgery tissue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.