Condition

Plasma Cell Leukemia clinical trials and research

• 17Clinical trials
• 13Countries

Newest Plasma Cell Leukemia clinical trials

All recruiting trials (17)

• Quadruplet induction plus autologous transplant followed by teclistamab maintenance for plasma cell leukemia

  This phase 2 trial tests whether adding teclistamab as consolidation after autologous stem cell transplant improves overall survival for patients with plasma cell leukemia compared with the standard D-KRd consolidation.

  Recruiting at 11 sites Phase 2 National Cancer Institute (NCI) · La Jolla, California and 10 other locations · NCT07605416

• Autologous stem‑cell transplant plus BCMA CAR‑T for ultra‑high‑risk multiple myeloma

  This test combines an autologous stem‑cell transplant with BCMA CAR‑T therapy to see if it helps adults (18–70) with ultra‑high‑risk multiple myeloma who are eligible for transplant.

  Recruiting Phase 1/2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT07109323

• CT0596 CAR-T treatment for plasma cell leukemia

  The study will try CT0596 CAR‑T cell therapy in adults with plasma cell leukemia to see if it is safe and can shrink the disease.

  Recruiting Early Phase 1 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT06988059

• Observational study on immunotherapy for multiple myeloma in Norway

  This study looks at how well new immunotherapy treatments for multiple myeloma work and what side effects they may cause for patients in Norway.

  Recruiting St. Olavs Hospital · Arendal and 22 other locations · NCT06855121

• Go-slow isatuximab and dexamethasone with later lenalidomide for ultra-frail multiple myeloma patients

  This trial will try a gentle, phased start of isatuximab and dexamethasone, adding lenalidomide later, for newly diagnosed, ultra-frail adults with multiple myeloma or plasma cell leukemia to help them stay on treatment and feel better.

  Recruiting Phase 2 University of Utah · Chicago, Illinois and 1 other locations · NCT06517017

• Collection and analysis of biological samples from patients with multiple myeloma and related conditions

  This study is collecting and storing blood samples from patients with multiple myeloma and similar conditions to help researchers learn more about these diseases and improve treatments.

  Recruiting at 41 sites European Myeloma Network B.V. · Melbourne and 40 other locations · NCT06237803

• Evaluating a new CAR-NK cell treatment for relapsed multiple myeloma and plasma cell leukemia

  This study is testing a new CAR-NK cell treatment to see if it can help people with relapsed multiple myeloma or plasma cell leukemia feel better and improve their condition.

  Recruiting Early Phase 1 Hrain Biotechnology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06045091

• Combination therapy for patients with primary plasma cell leukemia who cannot undergo transplant

  This study is testing a new combination treatment for patients with primary plasma cell leukemia who can't have a transplant to see if it helps manage their disease better.

  Recruiting Phase 2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin · NCT05979363

• Stem cell transplant using a specific preparative regimen for blood cancers

  This study is testing a new way to prepare for a stem cell transplant using a special combination of medications and radiation to see if it helps people with acute leukemia who are in remission.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05805605

• CAR-GPRC5D treatment for patients with relapsed or refractory multiple myeloma or plasma cell leukemia

  This study is testing a new CAR-T cell treatment called CAR-GPRC5D to see if it can help people with relapsed or hard-to-treat multiple myeloma or plasma cell leukemia.

  Recruiting Phase 1 Nanjing IASO Biotechnology Co., Ltd. · Shanghai · NCT05759793

• Registry for older adults with blood cancers

  This study is creating a registry for older adults with blood cancers to see how their health changes over time and to support future research.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05556928

• Budesonide's effect on diarrhea in multiple myeloma patients undergoing stem cell transplant

  This study is testing if budesonide can help reduce diarrhea in multiple myeloma patients who are getting a stem cell transplant.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT05405387

• Cohort of patients with plasma cell disorders at Peking University First Hospital

  This study is looking at hospitalized patients with plasma cell disorders to see how their treatment and disease status affect their outcomes over time.

  Recruiting Peking University First Hospital · Beijing · NCT05283993

• CAR-GPRC5D cell therapy for people with relapsed or refractory multiple myeloma or plasma cell leukemia

  This will try a one-time CAR-T treatment called CAR-GPRC5D after short chemotherapy in adults (18–75) whose multiple myeloma or plasma cell leukemia has returned or not responded after at least three prior treatments.

  Recruiting Phase 1 Tongji Hospital · Wuhan, Hubei · NCT05219721

• Using engineered immune cells with chemotherapy to treat blood cancers

  This study is testing if using special immune cells along with chemotherapy can help people with tough-to-treat blood cancers like B-cell lymphoma and leukemia feel better.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT05092451

• Registry for adults with plasma cell disorders

  This study is creating a registry for adults with plasma cell disorders like multiple myeloma to track their health and care experiences over time while also collecting blood samples for future research.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT03717844

• Hematopoietic stem cell transplant for blood cancers

  This study is testing two different ways of doing stem cell transplants for people with blood cancers to see which method works better and is safer.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT03314974

Related topics

Quick answers

How many Plasma Cell Leukemia clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (8 trials), China (7 trials), Norway (1 trial), Australia (1 trial), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 2, Early Phase 1: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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