Personalized exercise training to enhance physical ability in older adults with cardiac amyloidosis
Official title: Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis
Funded at Brigham and Women's Hospital · NIH-11072081 · Data updated 2026-11-12
This study is looking to see if a special 12-week exercise program can help older adults with heart issues from cardiac transthyretin amyloidosis feel stronger and improve their overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $184,537 |
| NIH project number | 5K23HL166686-03 |
| Project ID | NIH-11072081 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with cardiac transthyretin amyloidosis.
✕Less likely to help
Patients who are younger than 65 or do not have cardiac transthyretin amyloidosis may not benefit from this research.
What this research studies
This research focuses on improving the physical capabilities of older adults suffering from cardiac transthyretin amyloidosis (ATTR-CM), a condition that can lead to heart failure. The study will evaluate how personalized exercise training can enhance skeletal muscle performance and aerobic capacity, which are often compromised in these patients. Participants will undergo cardiopulmonary exercise testing and a short physical performance battery to assess their progress. The goal is to determine if a 12-week supervised exercise program can improve their quality of life.
Why it matters
Potential benefit: If successful, this research could significantly enhance the physical functioning and overall quality of life for patients with ATTR-CM.
How similar studies have gone: Previous research has shown that exercise interventions can improve physical function in various heart failure populations, suggesting potential success for this approach in ATTR-CM.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Cuddy, Sarah Am — Brigham and Women's Hospital
- Study coordinator: Cuddy, Sarah Am
Related research
Other NIH-funded projects on the same topics.
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Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers
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-
Chip phosphorylation boosts breakdown of mutant TTR to help heart amyloidosis
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Finding transthyretin heart amyloid from lumbar spine surgery tissue
This project looks for transthyretin (TTR) amyloid in tissue removed during lumbar spine surgery to find people who may later develop TTR cardiac amyloidosis.
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Blood biomarker test for heart amyloidosis in Black and Hispanic people
A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.
-
PET tracer to image cardiac amyloidosis
A new PET tracer is being developed to help visualize amyloid buildup in the heart, potentially helping people with amyloidosis and related heart disease.
-
Why losing parts of the Y chromosome may drive TTR heart amyloidosis in men
The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.