Personalized exercise training to enhance physical ability in older adults with cardiac amyloidosis
Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis
This study is looking to see if a special 12-week exercise program can help older adults with heart issues from cardiac transthyretin amyloidosis feel stronger and improve their overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11072081 on NIH RePORTER |
What this research studies
This research focuses on improving the physical capabilities of older adults suffering from cardiac transthyretin amyloidosis (ATTR-CM), a condition that can lead to heart failure. The study will evaluate how personalized exercise training can enhance skeletal muscle performance and aerobic capacity, which are often compromised in these patients. Participants will undergo cardiopulmonary exercise testing and a short physical performance battery to assess their progress. The goal is to determine if a 12-week supervised exercise program can improve their quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with cardiac transthyretin amyloidosis.
Not a fit: Patients who are younger than 65 or do not have cardiac transthyretin amyloidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance the physical functioning and overall quality of life for patients with ATTR-CM.
How similar studies have performed: Previous research has shown that exercise interventions can improve physical function in various heart failure populations, suggesting potential success for this approach in ATTR-CM.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cuddy, Sarah Am — Brigham and Women's Hospital
- Study coordinator: Cuddy, Sarah Am
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.