Detecting heart issues caused by protein buildup in older adults
Early Detection of Transthyretin Cardiac Amyloidosis: Defining a Novel Target for HFpEF Treatment and Prevention in Late Life
This study is looking for early signs of a heart condition called transthyretin cardiac amyloidosis (ATTR-CA) in older adults, using special imaging to spot changes in the heart before any symptoms show up, so that treatment can start sooner and help manage heart health better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10569547 on NIH RePORTER |
What this research studies
This research focuses on identifying early signs of transthyretin cardiac amyloidosis (ATTR-CA), a serious heart condition that affects many elderly individuals. By using advanced imaging techniques, the study aims to detect changes in heart structure and function before symptoms arise, which can lead to timely treatment. The research also seeks to understand how these changes relate to the presence of misfolded proteins in the heart, potentially improving diagnosis and management of heart failure with preserved ejection fraction (HFpEF). Participants will be monitored over several years to gather valuable data on heart health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals aged 70 and above who are at risk for heart failure but currently do not show symptoms.
Not a fit: Patients who are younger than 70 or those who already have a confirmed diagnosis of heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for older adults suffering from heart failure.
How similar studies have performed: Previous research has shown promise in using non-invasive imaging techniques for diagnosing similar cardiac conditions, indicating that this approach may be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dorbala, Sharmila — Brigham and Women's Hospital
- Study coordinator: Dorbala, Sharmila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.