Blood biomarker test for heart amyloidosis in Black and Hispanic people
Official title: Screening for Cardiac Amyloidosis with a Blood Biomarker in Minority Populations – SCABB-MP
Funded at Ut Southwestern Medical Center · NIH-11372835 · Data updated 2026-11-12
A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 15, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $553,184 |
| NIH project number | 5R01HL177670-02 |
| Project ID | NIH-11372835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with heart failure who are Black or Hispanic and at risk for transthyretin amyloidosis.
✕Less likely to help
Patients without ATTR-CA or those without access to blood biomarker testing may not benefit.
What this research studies
This research will validate a blood biomarker (TAD1) that detects transthyretin amyloid deposits in the heart using samples from a diverse group of patients. The study focuses on Black and Hispanic individuals with heart failure to see if TAD1 can reliably identify ATTR-CA. If successful, the test could become a simple, fast, and inexpensive tool to aid earlier diagnosis and treatment. The work builds on previous lab help from patient-derived heart tissue, aiming to move toward clinical use. It involves collaboration across institutions and a sizable patient cohort to ensure robust results.
Why it matters
Potential benefit: If successful, patients could receive earlier, more accurate diagnosis and timely treatment for cardiac ATTR amyloidosis.
How similar studies have gone: Prior work has shown promise in using peptide-based biomarkers to detect amyloid deposits, but validation in minority populations is ongoing.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Saelices Gomez, Lorena — Ut Southwestern Medical Center
- Study coordinator: Saelices Gomez, Lorena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.