Creating new models to study brain diseases like Alzheimer's
Official title: Developing new conditional models to study tauopathy, amyloidosis, and their interaction
Funded at University of Florida · NIH-10458822 · Data updated 2026-11-12
This study is creating special mouse models to help scientists learn more about how two important factors in Alzheimer's disease work together, which could lead to better understanding and treatments for people with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 17, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $1,817,356 |
| NIH project number | 4R33NS115178-02 |
| Project ID | NIH-10458822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals at risk for or diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with conditions unrelated to tauopathy or amyloidosis may not receive any benefit from this research.
What this research studies
This research focuses on developing innovative mouse models to better understand the interactions between tauopathy and amyloidosis, which are key factors in Alzheimer's disease and related disorders. The researchers aim to overcome the limitations of existing models by creating a new system that allows for the simultaneous study of these conditions. By integrating specific genetic components into the mouse genome, they hope to generate models that exhibit relevant disease characteristics at specific ages, providing a more accurate representation of the disease progression. This approach could lead to improved insights into the molecular pathways involved in Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Alzheimer's disease and related disorders.
How similar studies have gone: Other research has shown success in developing mouse models for Alzheimer's, but this approach aims to address specific limitations of existing models, making it a novel effort.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Lewis, Jada M — University of Florida
- Study coordinator: Lewis, Jada M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.