Investigating the role of amyloid-associated proteins in Alzheimer's disease
Official title: Amyloidosis associated proteins in Alzheimer’s disease pathogenesis
Funded at University of Florida · NIH-10890256 · Data updated 2026-11-12
This study is looking at how certain proteins linked to amyloid buildup in the brain might play a role in causing Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 5, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $757,775 |
| NIH project number | 4R01AG074569-02 |
| Project ID | NIH-10890256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores how certain proteins associated with amyloid deposits in the brain may contribute to the development of Alzheimer's disease. It aims to understand the complex relationship between the accumulation of amyloid beta (Aβ) and neurodegeneration, proposing that the presence of amyloid-associated proteins (AAPs) may be crucial for triggering neurodegenerative processes. By analyzing data from existing studies and using advanced proteomics techniques, the research seeks to identify these proteins and their roles in Alzheimer's pathology. This could lead to new insights into disease mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in understanding the role of amyloid proteins in Alzheimer's, but this approach focusing on amyloid-associated proteins is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Prokop, Stefan — University of Florida
- Study coordinator: Prokop, Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.