Investigating the role of ATTR amyloidosis in patients with aortic stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the prevalence and significance of ATTR aortic valve amyloidosis in patients undergoing aortic valve replacement surgery for degenerative aortic stenosis. It will utilize proteomic analysis to identify amyloid deposits in the aortic valve, which have previously been overlooked due to negative immunostaining results. By understanding the presence and implications of these deposits, the study seeks to clarify their clinical relevance in the context of cardiac amyloidosis. The findings could potentially reshape the understanding of degenerative aortic stenosis and its association with amyloidosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years old
* Degenerative aortic stenosis
* Aortic valve replacement surgery
* Signature of the informed consent form

Exclusion Criteria:

* Non-degenerative aortic stenosis: bicuspid, rheumatic disease, aortic regurgitation
* Persons under a system of legal protection for adults (guardianship, curatorship, etc.)
* Pregnant women

Where it's running

• university hospital center Toulouse
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Magali COLOMBAT, MD — University Hospital, Toulouse
• Study coordinator: Magali COLOMBAT, MD
• Email: colombat.m@chu-toulouse.fr
• Phone: 5 31 15 61 40

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.