Condition

AL Amyloidosis clinical trials and research

• 21Clinical trials
• 2NIH research projects
• 13Countries

Newest AL Amyloidosis clinical trials

All recruiting trials (21)

• SMS text check-ins to track symptoms for people with plasma cell disorders

  This study tests whether daily SMS symptom prompts are feasible and acceptable for adults starting treatment for multiple myeloma or AL amyloidosis.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07850284

• Hungarian National Systemic Amyloidosis Registry

  This registry collects medical data from adults with systemic amyloidosis across Hungary to help understand how the disease is diagnosed and treated in real-world practice.

  Recruiting at 12 sites Semmelweis University · Balatonfüred and 11 other locations · NCT07689331

• Tec Dara for newly diagnosed multiple myeloma with light chain amyloidosis

  This study tests whether tec listamab plus daratumumab can help newly diagnosed multiple myeloma with AL amyloidosis and whether the combination is safe.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai · NCT07638683

• How the IGLV1-44 light chain causes AL amyloidosis and POEMS

  This project tests whether specific IGLV1-44 light‑chain sequences drive AL amyloidosis and POEMS and whether nanobodies can recognize and stabilize those light chains in adults with AL amyloidosis, POEMS, or multiple myeloma.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT07448935

• How N-glycosylation of light chains affects AL amyloidosis diagnosis and treatment

  This project will test whether a sugar modification called N-glycosylation on immunoglobulin light chains helps cause disease or changes how AL amyloidosis and related monoclonal gammopathies behave in adults.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, PV · NCT07448779

• Belgian Amyloidosis Biobank and Patient Registry at UZ Leuven

  This project collects and stores blood, tissue samples, and medical data from adults with suspected or confirmed amyloidosis to create a biobank and registry for future research.

  Recruiting at 2 sites Universitaire Ziekenhuizen KU Leuven · Leuven and 1 other locations · NCT07172243

• Teclistamab treatment for newly diagnosed Mayo stage IIIB AL amyloidosis

  This Phase II trial will test teclistamab, an immune therapy, in people with newly diagnosed Mayo stage IIIB AL amyloidosis to see if it controls disease and is safe.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing · NCT07079423

• Skin tests to check biotherapy allergies in cancer patients

  We are testing skin tests to see if cancer patients treated with biotherapies have allergies or hypersensitivity to those drugs.

  Recruiting University Hospital, Angers · Angers · NCT06971848

• Teclistamab treatment for patients with AL Amyloidosis

  This study is testing if a new treatment called teclistamab can help people with AL Amyloidosis who haven't responded well to previous therapies.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06935162

• Observational study on immunotherapy for multiple myeloma in Norway

  This study looks at how well new immunotherapy treatments for multiple myeloma work and what side effects they may cause for patients in Norway.

  Recruiting St. Olavs Hospital · Arendal and 22 other locations · NCT06855121

• Using teclistamab to treat systemic AL amyloidosis

  This study is testing if teclistamab can help people with systemic AL amyloidosis who haven't responded to other treatments by seeing if it can eliminate harmful plasma cells and improve their health.

  Recruiting at 2 sites Peking University People's Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06699394

• Evaluating elranatamab for patients with relapsed or refractory AL amyloidosis

  This study is testing a new treatment called elranatamab to see if it can help people with relapsed or refractory AL amyloidosis feel better and manage their condition.

  Recruiting at 5 sites Phase 1/2 Dana-Farber Cancer Institute · New Haven, Connecticut and 4 other locations · NCT06569147

• Network for early diagnosis and management of AL amyloidosis in Italy

  This study is trying to set up a network in Italy to help doctors find AL amyloidosis earlier in patients who are at risk, so they can get treatment sooner and improve their health.

  Recruiting at 4 sites Fondazione IRCCS Policlinico San Matteo di Pavia · Bari and 3 other locations · NCT06383143

• Registry for diagnosing and managing AL amyloidosis in Europe

  This study is creating a registry to help doctors better diagnose and manage AL amyloidosis in Europe by collecting patient information and samples to learn more about the disease.

  Recruiting at 5 sites Fondazione IRCCS Policlinico San Matteo di Pavia · Heidelberg and 5 other locations · NCT06205953

• Optimizing first-line treatment for AL amyloidosis with specific genetic markers

  This study is testing a new treatment plan for people with AL amyloidosis who have a specific genetic marker to see if it helps them respond better and faster to their first-line therapy.

  Recruiting at 7 sites Peking University People's Hospital · Beijing, Beijing Municipality and 6 other locations · NCT06192979

• National Registry for Rare Kidney Diseases

  This study is collecting health information from people with rare kidney diseases to help improve treatments and create better care guidelines.

  Recruiting UK Kidney Association · Bristol, South West · NCT06065852

• Comparing chemotherapy with and without stem cell transplant for AL amyloidosis

  This study is testing whether adding a stem cell transplant to chemotherapy can help people with newly diagnosed AL amyloidosis live longer and have better organ health.

  Recruiting at 116 sites Phase 3 SWOG Cancer Research Network · Goodyear, Arizona and 116 other locations · NCT06022939

• Daratumumab maintenance therapy for AL amyloidosis

  This study tests whether shorter or longer maintenance therapy with daratumumab helps people with light chain amyloidosis stay healthy after their initial treatment.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT05898646

• Testing Belantamab Mafodotin for AL Amyloidosis

  This study is testing a new drug called Belantamab Mafodotin to see if it can safely help people with relapsed or hard-to-treat AL Amyloidosis feel better.

  Recruiting at 2 sites Phase 1/2 University of Texas Southwestern Medical Center · Nashville, Tennessee and 2 other locations · NCT05145816

• Registry for patients with AL amyloidosis

  This study is collecting information from people with AL amyloidosis to better understand the disease and how it changes over time.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT04839003

• Registry and sample resource for patients with plasma cell disorders

  This study is gathering information from patients with plasma cell disorders like multiple myeloma to see how to improve their treatment and quality of life.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT01408225

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Checking for AL amyloidosis in people with smoldering myeloma

  This project will use blood markers and clinical data to find hidden AL amyloidosis early in people with smoldering multiple myeloma.

  NIH research Tufts Medical Center · Boston, United States · NIH-11294139

• Improving early diagnosis of AL amyloidosis in patients with smoldering multiple myeloma

  This study is looking to find a better way to spot early signs of AL amyloidosis in people with smoldering multiple myeloma, so we can help them avoid serious health issues like heart and kidney problems.

  NIH research Tufts Medical Center · Boston, United States · NIH-11044135

Related topics

Quick answers

How many AL Amyloidosis clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (6 trials), Italy (5 trials), China (5 trials), Germany (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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