Identifying early signs of heart disease in certain Black individuals
Official title: IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELE
Funded at Ut Southwestern Medical Center · NIH-10871889 · Data updated 2026-11-12
This study is looking for people with a specific genetic variant linked to hereditary cardiac amyloidosis to find early signs of heart issues using special imaging and blood tests, so they can get treatment sooner and improve their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $706,193 |
| NIH project number | 5R01HL160892-03 |
| Project ID | NIH-10871889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black individuals who are carriers of the V122I TTR allele, particularly those who are asymptomatic.
✕Less likely to help
Patients who do not carry the V122I TTR allele or those with advanced symptoms of cardiac amyloidosis may not benefit from this research.
What this research studies
This research focuses on individuals who carry a specific genetic variant (V122I) associated with hereditary cardiac amyloidosis, a condition that can lead to severe heart failure. The study aims to detect early signs of this disease using advanced imaging techniques and biomarkers, which may not be evident through standard diagnostic methods. By identifying subclinical cardiac amyloidosis, the research seeks to enable earlier intervention with new therapies that can improve patient outcomes. Participants will undergo cardiac imaging and blood tests to assess their heart health and the presence of amyloid deposits.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of cardiac amyloidosis, potentially improving survival and quality of life for affected individuals.
How similar studies have gone: Previous research has shown promise in using imaging and biomarkers to detect early stages of cardiac amyloidosis, suggesting that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Grodin, Justin Lee — Ut Southwestern Medical Center
- Study coordinator: Grodin, Justin Lee
Related research
Other NIH-funded projects on the same topics.
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Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers
This project looks for early signs of heart damage in Black individuals who carry the V122I TTR variant and may benefit from new treatments if caught early.
-
Chip phosphorylation boosts breakdown of mutant TTR to help heart amyloidosis
A scientist-led project aims to help people with a heart disease caused by a mutant protein called transthyretin (TTR) by boosting the body’s protein-cleanup systems to remove the harmful TTR deposits.
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Finding transthyretin heart amyloid from lumbar spine surgery tissue
This project looks for transthyretin (TTR) amyloid in tissue removed during lumbar spine surgery to find people who may later develop TTR cardiac amyloidosis.
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Blood biomarker test for heart amyloidosis in Black and Hispanic people
A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.
-
PET tracer to image cardiac amyloidosis
A new PET tracer is being developed to help visualize amyloid buildup in the heart, potentially helping people with amyloidosis and related heart disease.
-
Why losing parts of the Y chromosome may drive TTR heart amyloidosis in men
The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.