Identifying early signs of heart disease in certain Black individuals
IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELE
This study is looking for people with a specific genetic variant linked to hereditary cardiac amyloidosis to find early signs of heart issues using special imaging and blood tests, so they can get treatment sooner and improve their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10871889 on NIH RePORTER |
What this research studies
This research focuses on individuals who carry a specific genetic variant (V122I) associated with hereditary cardiac amyloidosis, a condition that can lead to severe heart failure. The study aims to detect early signs of this disease using advanced imaging techniques and biomarkers, which may not be evident through standard diagnostic methods. By identifying subclinical cardiac amyloidosis, the research seeks to enable earlier intervention with new therapies that can improve patient outcomes. Participants will undergo cardiac imaging and blood tests to assess their heart health and the presence of amyloid deposits.
Who could benefit from this research
Good fit: Ideal candidates for this research are Black individuals who are carriers of the V122I TTR allele, particularly those who are asymptomatic.
Not a fit: Patients who do not carry the V122I TTR allele or those with advanced symptoms of cardiac amyloidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of cardiac amyloidosis, potentially improving survival and quality of life for affected individuals.
How similar studies have performed: Previous research has shown promise in using imaging and biomarkers to detect early stages of cardiac amyloidosis, suggesting that this approach could be effective.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Grodin, Justin Lee — Ut Southwestern Medical Center
- Study coordinator: Grodin, Justin Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.