Improving outcomes in cardiac amyloidosis using innovative imaging techniques
Official title: Mentoring Patient Oriented Research in Innovative Imaging and High-dimensional Data Approaches to Improve Outcomes in Cardiac Amyloidosis
Funded at Brigham and Women's Hospital · NIH-11127391 · Data updated 2026-11-12
This study is looking at new ways to use advanced imaging to improve how we diagnose and treat cardiac amyloidosis, helping doctors create personalized care plans for patients while also training future researchers in this important area.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $123,785 |
| NIH project number | 5K24HL157648-05 |
| Project ID | NIH-11127391 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cardiac amyloidosis, particularly those who may benefit from advanced imaging techniques.
✕Less likely to help
Patients with other forms of heart disease unrelated to amyloidosis may not receive benefits from this research.
What this research studies
This research focuses on enhancing the diagnosis and management of cardiac amyloidosis through advanced imaging techniques. The principal investigator, Dr. Sharmila Dorbala, aims to utilize molecular imaging to better understand the condition and develop personalized treatment strategies. The project also emphasizes mentoring the next generation of researchers in this field, ensuring that new approaches are effectively integrated into patient care. By exploring adjunct interventions and novel imaging methods, the research seeks to predict treatment outcomes more accurately.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and personalized treatment options for patients with cardiac amyloidosis.
How similar studies have gone: Previous research has shown promising results using advanced imaging techniques in similar conditions, indicating a strong potential for success in this innovative approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Dorbala, Sharmila — Brigham and Women's Hospital
- Study coordinator: Dorbala, Sharmila
Related research
Other NIH-funded projects on the same topics.
-
Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers
This project looks for early signs of heart damage in Black individuals who carry the V122I TTR variant and may benefit from new treatments if caught early.
-
Chip phosphorylation boosts breakdown of mutant TTR to help heart amyloidosis
A scientist-led project aims to help people with a heart disease caused by a mutant protein called transthyretin (TTR) by boosting the body’s protein-cleanup systems to remove the harmful TTR deposits.
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Finding transthyretin heart amyloid from lumbar spine surgery tissue
This project looks for transthyretin (TTR) amyloid in tissue removed during lumbar spine surgery to find people who may later develop TTR cardiac amyloidosis.
-
Blood biomarker test for heart amyloidosis in Black and Hispanic people
A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.
-
PET tracer to image cardiac amyloidosis
A new PET tracer is being developed to help visualize amyloid buildup in the heart, potentially helping people with amyloidosis and related heart disease.
-
Why losing parts of the Y chromosome may drive TTR heart amyloidosis in men
The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.