Improving early diagnosis of AL amyloidosis in patients with smoldering multiple myeloma
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
['FUNDING_R01'] · TUFTS MEDICAL CENTER · NIH-11044135
This study is looking to find a better way to spot early signs of AL amyloidosis in people with smoldering multiple myeloma, so we can help them avoid serious health issues like heart and kidney problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11044135 on ClinicalTrials.gov |
What this research studies
This research aims to enhance the early detection of systemic light-chain (AL) amyloidosis in individuals diagnosed with smoldering multiple myeloma, a condition where patients produce abnormal light chains but show few symptoms. The study will utilize a series of screening criteria and algorithms to identify patients at risk for developing AL amyloidosis, which can lead to severe complications like heart and kidney failure. By enrolling 340 patients, the research seeks to establish a network that will facilitate better diagnosis and management of this condition, ultimately aiming to reduce mortality rates associated with late diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with smoldering multiple myeloma who are asymptomatic but may be at risk for developing AL amyloidosis.
Not a fit: Patients who do not have smoldering multiple myeloma or those already diagnosed with AL amyloidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of AL amyloidosis, significantly improving patient outcomes and survival rates.
How similar studies have performed: Previous studies have indicated that early detection strategies for AL amyloidosis can significantly impact patient outcomes, suggesting that this approach has the potential for success.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COMENZO, RAYMOND LUKE — TUFTS MEDICAL CENTER
- Study coordinator: COMENZO, RAYMOND LUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced disease, amyloid disease