Sponsor or institution

Clinical trials and research at University of California-Irvine

• 78Clinical trials
• 898NIH research projects
• 2Countries

Newest trials

All recruiting trials (78)

• Pilot test of an active surveillance approach for brain metastases during CNS-penetrant systemic therapy

  A small observational study tests whether an active surveillance plan for newly progressing brain metastases during CNS-penetrant systemic therapy is safe for patients.

  Recruiting University of California, Irvine · Orange, California · NCT07827001

• Nerve block to treat severe belly pain in the emergency department

  This study tests whether injecting anesthesia into the erector spinae plane can relieve non-surgical abdominal pain in the ED without relying on narcotics.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07826936

• Paclitaxel given inside the abdomen with systemic therapy for GI cancers with peritoneal spread

  This phase II study tests a combination of intraperitoneal and systemic chemotherapy (paclitaxel) in adults with digestive tract cancers that have spread to the peritoneum.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07795749

• Empowering patients to get lung cancer screening with support and navigation

  This pilot study tests a patient navigation and education program to see if it helps adults who are eligible start and complete low-dose CT lung cancer screening.

  Recruiting at 13 sites University of California, Irvine · Anaheim, California and 56 other locations · NCT07711691

• Metformin in PMP from appendiceal mucinous neoplasms

  This pilot study tests whether metformin is feasible to use in adults with pseudomyxoma peritonei caused by appendiceal mucinous tumors who have recurrent or unresected disease.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07693452

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• Reiki to support immunotherapy-related fatigue, pain, and stress in adults with cancer

  This pilot will try Reiki, a gentle hands-near relaxation therapy, to see if it helps adults with cancer on immunotherapy who are experiencing fatigue, pain, or emotional distress.

  Recruiting at 2 sites University of California, Irvine · Irvine, California and 1 other locations · NCT07581080

• Gemcitabine plus nab‑paclitaxel with or without pitavastatin for unresectable pancreatic adenocarcinoma

  This phase 1 test looks at whether adding pitavastatin to ongoing gemcitabine‑based chemotherapy is safe and may help people with unresectable or metastatic pancreatic adenocarcinoma.

  Recruiting Phase 1 University of California, Irvine · Orange, California · NCT07549958

• Safety and tolerability of human neural stem cell implants for Huntington's disease

  This research will test whether an implant of hNSC-01 human neural stem cells is safe and tolerable for adults with Huntington's disease.

  Recruiting Phase 1/2 University of California, Irvine · Irvine, California · NCT07451613

• Riluzole to prevent thinking and memory problems during chemotherapy

  This pilot trial tests whether riluzole can prevent thinking and memory problems in adults with cancer receiving anthracycline- or platinum-based chemotherapy.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07447050

• Nelfinavir to improve anemia in people with myelofibrosis by restoring iron delivery to the bone marrow

  This trial tests whether the antiviral drug nelfinavir can help people with myelofibrosis and anemia by raising hemoglobin and lowering blood markers of fibrosis.

  Recruiting Phase 1/2 University of California, Irvine · Orange, California · NCT07281781

• How ibogaine changes brain activity in opioid use disorder.

  This study will test whether ibogaine changes brain activity and symptoms in adults with moderate-to-severe opioid use disorder who are already planning legal treatment.

  Recruiting University of California, Irvine · Irvine, California · NCT07226570

• Preventing cervical cancer in women with HPV and HIV in Karnataka, India

  This trial will test whether a six-month ASHA-Health program of group education, ASHA-supported one-on-one sessions, nutrition support, and life-skills training can reduce persistent high-risk HPV in women living with HIV.

  Recruiting at 3 sites University of California, Irvine · Bangalore, Karnataka and 3 other locations · NCT07209917

• Telemedicine support for people considering living kidney donation

  This trial tests whether telemedicine video visits can help adults in California who are registered living kidney donor candidates get education, counseling, and support compared with standard care.

  Recruiting University of California, Irvine · Orange, California · NCT07206069

• Postpartum Preeclampsia Care Using Point-of-Care Ultrasound and Diuretics

  The study tests whether using bedside ultrasound to guide diuretic therapy can improve outcomes for adults with preeclampsia after delivery.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT07167862

• Cognitive-behavioral resilience training for parolees adjusting after release

  This pilot will test a short, five-session cognitive-behavioral program to see if it helps recently released parolees feel more adjusted and improve well-being.

  Recruiting University of California, Irvine · Los Angeles, California · NCT07167719

• Single-protein encapsulated doxorubicin (SPEDOX-6) for advanced solid tumors

  We will try SPEDOX-6, a protein-encapsulated form of doxorubicin, to find a safe dose and see if it helps adults with advanced, treatment-resistant solid tumors (including certain sarcomas, triple-negative breast cancer, non-small cell lung cancer, cervical, ovarian, and KRAS‑mutant pancreatic cancers) who have not rec

  Recruiting Phase 1/2 University of California, Irvine · Orange, California · NCT07064018

• Lung cancer screening for family members of people with mutation-driven lung cancer

  This project will use low-dose CT scans to see if immediate family members aged 40–80 of people with driver-mutated lung cancer have inherited risk or early lung cancer.

  Recruiting University of California, Irvine · Orange, California · NCT07062172

• Smartwatch plus coaching to increase affected arm use after stroke

  This trial will test whether a smartwatch that tracks arm movement combined with short motivational coaching can help people with chronic stroke use their affected arm more in daily life.

  Recruiting University of California, Irvine · Irvine, California · NCT07042152

• Using music therapy to improve quality of life in sickle cell disease

  This study is testing if music therapy can help improve the quality of life for teenagers and adults with sickle cell disease.

  Recruiting University of California, Irvine · Cleveland, Ohio and 1 other locations · NCT06853158

• IntraTumor T-Cell Boost with Dual Immune Checkpoint Inhibitors in ARID1A-Mutated Esophageal/Gastric Adenocarcinoma

  A first-in-human test of a single-dose combination of tremelimumab and durvalumab in adults with ARID1A-mutated, non-metastatic esophageal, GEJ, or stomach adenocarcinoma to see if it can increase tumor T cells.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT06824363

• Exploring how stress affects memory in adolescents

  This study tests how stress affects memory in teenagers, especially those who have faced tough situations, to see if their memories of stressful events are different from those who have had stable home lives.

  Recruiting University of California, Irvine · Irvine, California · NCT06821178

• Teaching healthy regulation to adolescents in challenging environments

  This study is testing a coaching program called GRIT to see if it can help young teens who have faced tough challenges avoid using alcohol and cannabis.

  Recruiting University of California, Irvine · Irvine, California · NCT06821035

• A new surgical approach to reduce GERD after weight loss surgery

  This study is testing a new type of weight loss surgery to see if it can help reduce acid reflux in people who have had weight loss surgery.

  Recruiting at 2 sites University of California, Irvine · Orange, California and 1 other locations · NCT06783751

• Using Cyclophosphamide and Pembrolizumab for advanced melanoma treatment

  This study is testing if a combination of Cyclophosphamide and Pembrolizumab can help people with advanced melanoma who haven't responded to other treatments feel better and improve their health.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06771544

• EndoPAT to measure blood vessel health in men with erectile dysfunction and hypogonadism

  This project will test whether EndoPAT can detect changes in blood-vessel function in men with vasculogenic ED or hypogonadism before and 3–6 months after starting daily low-dose PDE5 inhibitors or testosterone therapy.

  Recruiting University of California, Irvine · Newport Beach, California · NCT06720597

• Evaluating the effects of AHCC in HPV-positive head and neck cancer patients

  This study is testing whether AHCC capsules are safe and well-tolerated for adults with HPV-positive head and neck cancer who are undergoing surgery.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06693323

• Vaginal treatment for menopause symptoms using CO2 laser

  This study is testing if a CO2 laser treatment can help relieve vaginal dryness and discomfort in women going through menopause who can't use hormone therapy.

  Recruiting University of California, Irvine · Irvine, California · NCT06691178

• Combination therapy for high-risk muscle-invasive bladder cancer

  This study is testing if a combination of two cancer drugs can help people with high-risk bladder cancer stay cancer-free after surgery.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06682728

• Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues

  This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06580002

• Exploring the effects of Core Shamanism on fibromyalgia symptoms

  This study is testing whether a special shamanic treatment can help people with fibromyalgia feel less pain and improve their symptoms over eight weeks.

  Recruiting University of California, Irvine · Irvine, California · NCT06579261

• Effects of acupuncture on opioid pain relief in fibromyalgia patients

  This study tests if traditional acupuncture can make opioid pain relief better for people with fibromyalgia.

  Recruiting University of California, Irvine · Irvine, California · NCT06571110

• Investigating Energy Healing for Fibromyalgia

  This study is testing whether energy healing can help people with fibromyalgia feel better by looking at how it affects their brain activity and pain levels compared to a fake treatment.

  Recruiting University of California, Irvine · Irvine, California · NCT06552728

• Using pafolacianine for imaging during surgery for gastrointestinal cancer

  This study is testing if a special imaging drug called pafolacianine can help doctors find cancer spots better during surgery for adults with gastrointestinal cancer.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT06511037

• Evaluating CMV Prophylaxis After Stem Cell Transplant

  This study is testing if a new test can help doctors decide how long to give a specific medicine to prevent a virus in patients who have had a stem cell transplant.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06453460

• Using ICG to improve sexual function outcomes after prostate surgery

  This study is testing whether using a special dye during prostate surgery can help improve sexual function for men after their operation.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT06446648

• Acupuncture for people at high risk for sepsis

  This study is testing if real acupuncture can help people at high risk for sepsis recover better than sham acupuncture.

  Recruiting Phase 2 University of California, Irvine · Irvine, California · NCT06344819

• Biobehavioral intervention for Latino/Hispanic young adults with cancer

  This study is testing two different types of therapy to see which one helps Latino/Hispanic young adults who have survived cancer feel better and manage stress.

  Recruiting University of California, Irvine · Irvine, California · NCT06338475

• Comparing mpMRI and TURBT for diagnosing muscle-invasive bladder cancer

  This study is testing whether a special type of MRI can accurately diagnose muscle-invasive bladder cancer compared to a common surgical procedure in patients who might have this type of cancer.

  Recruiting University of California, Irvine · Orange, California · NCT06335667

• Using sodium bicarbonate to change 24-hour urine measurements in people with low urine citrate or uric acid kidney stones

  This will see if taking sodium bicarbonate instead of potassium citrate changes 24-hour urine measurements in adults with low urine citrate or uric acid kidney stones.

  Recruiting Phase 1 University of California, Irvine · Orange, California · NCT06335537

• Positive Affect Treatment for Teens Facing Early Life Challenges

  This study is testing a new treatment called Positive Affect Treatment to see if it can help teens aged 12-16 who have faced tough childhood experiences feel happier and less depressed.

  Recruiting University of California, Irvine · Irvine, California · NCT06273137

• Examining how personality affects medication adherence in chronic myeloid leukemia patients

  This study is trying to see how different personality traits affect whether people with chronic myeloid leukemia stick to their medication plan.

  Recruiting University of California, Irvine · Orange, California · NCT06229860

• Examining gut microbiome diversity in patients with advanced lung cancer during treatment

  This study is trying to see how the variety of gut bacteria in patients with advanced lung cancer affects their response to treatment and any side effects they might have.

  Recruiting University of California, Irvine · Orange, California · NCT06221800

• Personalized conditioning regimen for stem cell transplantation

  This study is testing a personalized treatment plan for stem cell transplants in people with blood cancers to see if adjusting the doses of certain medications can improve their outcomes.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06028828

• Improving surgical outcomes for Latinx children

  This study is testing a mobile health program to help Latinx children aged 2-7 feel less anxious and manage pain better before and after their outpatient surgeries.

  Recruiting University of California, Irvine · Orange, California · NCT06020677

• Comparing short and long antibiotic courses for severe skin infections

  This study is testing whether a shorter 48-hour course of antibiotics is just as safe and effective as a longer 7-day course for patients with severe skin infections.

  Recruiting University of California, Irvine · Orange, California · NCT06002607

• Using medication and lifestyle counseling to manage weight regain after bariatric surgery

  This study is testing whether a combination of medication and lifestyle counseling can help people who have regained weight after bariatric surgery lose that weight again.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT05975580

• Creating a model using patient samples for gastrointestinal cancer research

  This study is trying to create a model using samples from patients with gastrointestinal cancer to better understand the disease and find better treatments.

  Recruiting University of California, Irvine · Orange, California · NCT05844865

• Biobehavioral intervention for young adult testicular cancer survivors

  This study is testing a new therapy to help young adult testicular cancer survivors manage their emotions and stress better, comparing it to regular supportive listening over eight weeks.

  Recruiting University of California, Irvine · Irvine, California · NCT05836688

• Impact of eating before WALANT procedures on patient anxiety and outcomes

  This study tests if eating a light meal before certain surgeries can help reduce anxiety and improve satisfaction for patients.

  Recruiting University of California, Irvine · Orange, California · NCT05819801

• Response-adapted neoadjuvant therapy for gastroesophageal adenocarcinoma

  It tests whether adjusting pre-surgery chemotherapy based on early treatment response helps adults with stage IB–III stomach or gastroesophageal junction adenocarcinoma.

  Recruiting Phase 1 University of California, Irvine · Orange, California · NCT05733689

• Effects of mouthrinse on oral and gut bacteria and viruses

  This study is testing how two popular mouthwashes affect the bacteria and viruses in your mouth and gut over six months.

  Recruiting University of California, Irvine · Irvine, California · NCT05603650

• Reduced radiation treatment for HPV-positive throat cancer

  This study is testing if a lower dose of radiation can effectively treat HPV-positive throat cancer while causing fewer side effects for patients.

  Recruiting University of California, Irvine · Orange, California · NCT05600842

• Reducing surgical site infections after colon or small bowel surgery

  This study is testing whether using special washes and ointments can help prevent infections after colon or small bowel surgery for patients who have just been discharged from the hospital.

  Recruiting at 4 sites Phase 4 University of California, Irvine · Newport Beach, California and 3 other locations · NCT05586776

• Using migraine medications to treat Meniere's disease

  This study is testing whether migraine medications can help people with Meniere's disease feel better by reducing their vertigo, hearing loss, and tinnitus.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT05582837

• Using acupuncture to lower blood pressure in people with mild to moderate hypertension

  This study is testing if acupuncture can help lower blood pressure in people aged 45 to 75 who have mild to moderate hypertension.

  Recruiting at 2 sites University of California, Irvine · Irvine, California and 1 other locations · NCT05530512

• Combination therapy for hormone receptor-positive metastatic breast cancer

  This study is testing a new combination of three medications to see if it can help people who have just been diagnosed with advanced hormone receptor-positive breast cancer or those who have had a relapse after being cancer-free for over a year.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT05524584

• Comparing blood samples from cancer-draining veins to standard veins in patients with liver and pancreatic cancers

  This study is testing if taking blood samples from veins near liver and pancreatic tumors can help find cancer DNA better than using regular veins in patients getting biopsies.

  Recruiting University of California, Irvine · Orange, California · NCT05497531

• Assessing Oral Health Using Imaging and Products

  This study is testing whether using certain toothpastes and mouthwashes can improve gum health and oral hygiene by tracking changes in plaque levels and gum condition over time.

  Recruiting University of California, Irvine · Irvine, California · NCT05470023

• Exploring the effects of exercise on children's health with chronic diseases

  This study is testing how exercise can improve the health of children with chronic diseases like cystic fibrosis and sickle cell disease to find safe ways for them to be active.

  Recruiting University of California, Irvine · Irvine, California · NCT05359991

• Using micro/nanobubbles to heal acute and chronic wounds

  This study is testing if tiny bubbles can help heal both new and long-lasting wounds by improving oxygen delivery to the affected areas.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT05169814

• Finding the best dose of N-Acetylcysteine for patients with blood disorders

  This study is testing the best dose of N-Acetylcysteine to see if it can help people with certain blood disorders feel better while they continue their usual treatments.

  Recruiting Phase 1/2 University of California, Irvine · Irvine, California and 1 other locations · NCT05123365

• Using nicotine to improve hearing in older adults

  This study tests if nicotine can help improve hearing in older adults by comparing its effects to a placebo.

  Recruiting at 2 sites University of California, Irvine · Irvine, California and 1 other locations · NCT04971954

• Using ctDNA to guide treatment changes for colon cancer

  This study is testing if a new combination of cancer treatments can help people with colon cancer who still have traces of the disease after surgery feel better and live longer.

  Recruiting Phase 1 University of California, Irvine · Orange, California · NCT04920032

• Examining anticoagulation in pregnant women using Lovenox three times a day

  This study tests if giving pregnant women Lovenox three times a day helps keep their blood thinner and safer from clots compared to the usual twice-daily dose.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT04861103

• Evaluation of middle ear infections using light measurements

  This study is testing a new way to diagnose middle ear infections in children by shining special LED lights into the ear to see if there's any fluid or inflammation.

  Recruiting at 2 sites University of California, Irvine · Orange, California and 1 other locations · NCT04812093

• NAC to help with chemo-related thinking problems in ovarian cancer patients on platinum therapy

  This trial tests whether adding N-acetyl-cysteine (NAC) can help prevent cognitive changes in women with advanced ovarian cancer who are receiving platinum-based chemotherapy.

  Recruiting Phase 1/2 University of California, Irvine · Orange, California · NCT04520139

• Combining cabozantinib with ipilimumab/nivolumab and TACE for liver cancer treatment

  This study is testing if combining cabozantinib with two immune therapies and a specific type of chemo can help people with liver cancer who can’t have surgery feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT04472767

• Thyroid hormone supplementation for patients on hemodialysis

  This study is testing if a thyroid hormone pill can help people on hemodialysis with mild thyroid issues feel better and improve their heart health.

  Recruiting University of California, Irvine · Orange, California · NCT03977207

• Exploring biomarkers related to aging and cognitive decline

  This study is testing if new brain scans and memory tests can help find early signs of Alzheimer's disease in healthy older adults aged 60 to 85.

  Recruiting Phase 3 University of California, Irvine · Irvine, California · NCT03860857

• Acoustic and Electrical Stimulation for Tinnitus

  Researchers are testing whether specific sounds or electrical stimulation of the inner ear can reduce or eliminate tinnitus in adults who have had it for at least six months.

  Recruiting University of California, Irvine · Irvine, California · NCT03511807

• Non-invasive imaging of skin lesions using advanced microscopy

  This study is testing a new imaging technique to see if it can safely and accurately capture details of skin lesions without needing a biopsy.

  Recruiting University of California, Irvine · Irvine, California · NCT01771718

• Evaluating non-invasive imaging techniques for blood flow assessment

  This study is testing new non-invasive imaging techniques to see how well they can measure blood flow changes in the skin when a pressure cuff is applied.

  Recruiting University of California, Irvine · Irvine, California · NCT01484730

• Understanding Inclusion Body Myopathy, Paget's Disease, and Frontotemporal Dementia

  This study is trying to learn more about how changes in the VCP gene affect people with inherited muscle, bone, and brain conditions, by collecting health information and samples from families who have these issues.

  Recruiting University of California, Irvine · Irvine, California · NCT01353430

• Using imaging techniques to assess burn wound severity and healing

  This study tests if new imaging techniques can better determine how serious burn wounds are and how well they heal in patients with partial thickness burns.

  Recruiting University of California, Irvine · Orange, California · NCT01166893

• Characterizing inherited muscle disease with Paget bone disease

  This observational study will use painless infrared tissue scans and genetic analysis to try to find inherited causes of combined muscle and bone disorders in adults and their family members.

  Recruiting University of California, Irvine · Irvine, California · NCT01166854

• Electro-acupuncture's effect on lowering blood pressure

  This study is testing whether electro-acupuncture can help lower blood pressure in people with mild to moderate hypertension, especially looking at how it works for different genders.

  Recruiting at 2 sites University of California, Irvine · Irvine, California and 1 other locations · NCT00932139

• Investigating the role of blood vessel growth in skin diseases

  This study looks at how the growth of blood vessels affects skin diseases like port wine stains and psoriasis to better understand their causes and treatments.

  Recruiting at 2 sites University of California, Irvine · Irvine, California and 1 other locations · NCT00842283

NIH-funded research (newest 40 of 898)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Retinal cell grafts to restore sight in AMD and RP

  A patient-focused program aims to replace damaged retinal cells with organized, transplant-ready sheets created from stem cells to improve vision in age-related macular degeneration and related diseases.

  NIH research University of California-Irvine · Irvine, United States · NIH-11641966

• Treg-based tolerance to dystrophin immune responses in Duchenne muscular dystrophy

  A new grant aims to help people with Duchenne muscular dystrophy by teaching the immune system to tolerate the dystrophin treatment delivered by gene therapy.

  NIH research University of California-Irvine · Irvine, United States · NIH-11629772

• Immune and NGF factors in Alzheimer’s for adults with Down syndrome

  This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.

  NIH research University of California-Irvine · Irvine, United States · NIH-11582785

• Promoting Heart Cell Maturation with Light-Activated Engineered Peptides

  Aims to help grown heart cells from stem cells mature more like real adult heart tissue using special peptide coatings that respond to light.

  NIH research University of California-Irvine · Irvine, United States · NIH-11566193

• Understanding how heart nerves affect dangerous heart rhythms after a heart attack

  This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.

  NIH research University of California-Irvine · Irvine, United States · NIH-11565444

• All of Us Southern California Consortium supports broad participation in a national health data program

  A national health data program in Southern California works to recruit and retain adults to share health information and participate in research that uses this data.

  NIH research University of California-Irvine · Irvine, United States · NIH-11551605

• Short-Course TB Prevention for People with HIV: Better Adherence with Facilitated 3HP Delivery

  A trial tests easier, supportive ways to help people with HIV complete a short, weekly TB preventive treatment (3HP).

  NIH research University of California-Irvine · Irvine, United States · NIH-11549398

• Options for Delivering Short-Course TB Preventive Therapy for People with HIV

  A trial tests easier, shorter TB-prevention therapy (3HP) for people living with HIV to see if simplified support helps them complete treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-11549390

• Undiagnosed Disease Network in Southern California

  A patient-facing program in Southern California helps people with unexplained medical problems connect with experts to find answers.

  NIH research University of California-Irvine · Irvine, United States · NIH-11537948

• Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)

  A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.

  NIH research University of California-Irvine · Irvine, United States · NIH-11536966

• Secondary cervical cancer prevention for vulnerable women with HPV and HIV in India

  A patient-friendly program in India aims to help women living with HIV reduce cervical cancer risk through HPV screening, nutrition, and emotional support.

  NIH research University of California-Irvine · Irvine, United States · NIH-11535290

• Secondary cervical cancer prevention for women with HIV in India

  This project tests a nurse-led, peer-supported program to help women with HIV who are at risk for cervical cancer through HPV screening, nutrition, and emotional support in rural India.

  NIH research University of California-Irvine · Irvine, United States · NIH-11535289

• Nutrition-based plan to ease pain in sickle cell disease

  A nutrition-based approach is being tested to reduce pain for people living with sickle cell disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11533140

• Advancing proteomics tools to understand the proteasome system

  This NIH grant funds researchers to develop better proteomics technologies so scientists can understand how the proteasome system works in humans.

  NIH research University of California-Irvine · Irvine, United States · NIH-11529364

• Center study of how genetic variants affect gene activity in mouse cells

  A research center will study how millions of human-like genetic differences influence gene activity in mouse cells to better understand complex diseases.

  NIH research University of California-Irvine · Irvine, United States · NIH-11516206

• Malaria risk in Ethiopian cities and countryside

  This work looks at how malaria spreads and whether mosquito control can better protect people living in Ethiopian cities and rural areas where the invasive Anopheles stephensi mosquito is present.

  NIH research University of California-Irvine · Irvine, United States · NIH-11515813

• Tracking the invasive Anopheles stephensi mosquito in Ethiopia's towns and countryside

  This project looks at ways to detect and control the invasive Anopheles stephensi mosquito in urban and rural communities in Ethiopia to help reduce malaria risk for local residents.

  NIH research University of California-Irvine · Irvine, United States · NIH-11515812

• Malaria in Ethiopia's cities and nearby rural areas

  This project follows malaria infections and mosquito spread across Ethiopian cities and surrounding rural communities to find who is at risk, especially where the invading Anopheles stephensi mosquito has appeared.

  NIH research University of California-Irvine · Irvine, United States · NIH-11515811

• Tracking the invasive urban mosquito Anopheles stephensi in Ethiopia

  Researchers are finding how a new urban mosquito spreads across Ethiopian towns and cities to help protect people from malaria.

  NIH research University of California-Irvine · Irvine, United States · NIH-11515810

• USDHub: a shared resource to advance urinary stone disease research

  A large, multi-system project is creating a shared data hub to help researchers study urinary stone disease in both kids and adults.

  NIH research University of California-Irvine · Irvine, United States · NIH-11506054

• Are memory problems linked to loss of pleasure (anhedonia)?

  This project looks at whether memory problems help explain why adults with conditions like depression, PTSD, or schizophrenia lose interest in things they used to enjoy.

  NIH research University of California-Irvine · Irvine, United States · NIH-11501053

• Tracking the invasive Anopheles stephensi mosquito and malaria spread in Ethiopia

  This project follows a new mosquito species spreading in Ethiopia to learn how it changes malaria risk for people in cities and nearby rural areas.

  NIH research University of California-Irvine · Irvine, United States · NIH-11498202

• How the invasive mosquito Anopheles stephensi is changing malaria risk in Ethiopia

  This project looks at how the invasive mosquito Anopheles stephensi spreads in cities and rural areas of Ethiopia and what that means for people at risk of malaria.

  NIH research University of California-Irvine · Irvine, United States · NIH-11498201

• Predicting tuberculosis progression in young children with and without HIV

  This project will look for blood markers that show which young children with or without HIV are most likely to develop active tuberculosis so they can get earlier prevention or treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-11488586

• How TB progresses in young children with and without HIV

  This project looks for blood or other markers that can tell which young children with TB infection, including those living with HIV, are most likely to develop active TB so they can get preventive treatment early.

  NIH research University of California-Irvine · Irvine, United States · NIH-11488584

• New epigenetic regulators that guide T cell development

  Aims to find epigenetic factors that control how T cells develop from stem cells to improve cell-based therapies for autoimmune diseases.

  NIH research University of California-Irvine · Irvine, United States · NIH-11486060

• How cells use ubiquitin and metabolism signals to control growth

  Researchers are looking at how a small protein tag called ubiquitin and metabolic signals help control cell growth in ways that could help people with cancer.

  NIH research University of California-Irvine · Irvine, United States · NIH-11481902

• How inflammation affects JAK2‑mutant blood cells

  This project looks at whether inflammation helps JAK2‑mutant blood cells grow in people with early myeloproliferative neoplasms and could point to ways to slow disease progression.

  NIH research University of California-Irvine · Irvine, United States · NIH-11473217

• Smartphone screening and affordable genetic testing for babies and young children

  A smartphone AI app paired with low-cost genetic testing to help find genetic syndromes like Down syndrome in babies and young children in low-resource countries.

  NIH research University of California-Irvine · Irvine, United States · NIH-11472546

• Brain small-vessel injury and its link to Alzheimer's disease

  This project will look for connections between small blood-vessel damage in the brain and later memory decline in older adults without dementia, including Black and Hispanic participants.

  NIH research University of California-Irvine · Irvine, United States · NIH-11472083

• How the TBX1 gene shapes early throat and heart development in 22q11.2 deletion syndrome

  This project looks at how reduced TBX1 gene activity changes early throat and heart tissue development in people with 22q11.2 deletion syndrome.

  NIH research University of California-Irvine · Irvine, United States · NIH-11468525

• How brain immune cells and the SYK protein affect Alzheimer's

  This project tests whether changing a protein called SYK in brain immune cells (microglia) can slow or prevent Alzheimer's disease in people with or at risk for the condition.

  NIH research University of California-Irvine · Irvine, United States · NIH-11456933

• TLR4 blocker for improving fertility in PCOS

  A promising, already-approved drug (disulfiram) will be tested to see if it can reduce inflammation and improve ovulation in women with PCOS.

  NIH research University of California-Irvine · Irvine, United States · NIH-11456298

• Social networks, stigma, and HIV care among forcibly displaced MSM in Ukraine

  This project will look at how broken social networks and stigma affect HIV testing, care, and transmission among men who have sex with men who were forcibly displaced in Ukraine.

  NIH research University of California-Irvine · Irvine, United States · NIH-11455240

• Vector-capacity of the invasive Anopheles stephensi mosquito in Ethiopia

  This grant studies how the invasive Anopheles stephensi mosquito spreads malaria in urban Ethiopia and how it might affect transmission to people.

  NIH research University of California-Irvine · Irvine, United States · NIH-11455143

• New candidate drugs to treat malaria and babesiosis from natural compounds

  A new program tests natural compound relatives to find safe, effective medicines for malaria and babesiosis that could work even when current drugs fail.

  NIH research University of California-Irvine · Irvine, United States · NIH-11450339

• Robot-assisted hand movement training after stroke

  A study testing a robotic hand training program to help people recover hand movement after a stroke.

  NIH research University of California-Irvine · Irvine, United States · NIH-11450292

• Community-led program to improve quality of life for Spanish-speaking families caring for a child with cancer

  A family-centered, culturally responsive program aims to support Spanish-speaking caregivers of children with cancer and improve their quality of life.

  NIH research University of California-Irvine · Irvine, United States · NIH-11450084

• Cochlear-Implant Pitch Feel: A Penetrating Nerve Electrode to Improve Hearing

  A new cochlear implant approach uses a penetrating nerve electrode to improve how people perceive pitch and understand speech in noisy places.

  NIH research University of California-Irvine · Irvine, United States · NIH-11448591

• Abeta beta-Hairpin Peptides and Oligomers as Treatments for Alzheimer's Disease

  Aims to develop vaccines and antibodies that target early amyloid beta shapes to slow Alzheimer’s in people who have or are at risk for the disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11447956

Quick answers

How many clinical trials run by University of California-Irvine are recruiting right now?

78, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (77 trials), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 12, Early Phase 1: 6, Phase 1/2: 5, Phase 4: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →