Lung cancer screening for family members of people with mutation-driven lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm screening effort that enrolls index patients with a confirmed driver mutation and invites their first-degree relatives for screening. Eligible relatives (ages 40–80) with under 20 pack-years smoking history undergo a low-dose chest CT to look for early lung cancer. The study collects questionnaire and imaging data to explore whether certain driver mutations cluster in families and whether screening can detect tumors early. The program is conducted at the Chao Family Comprehensive Cancer Center at UC Irvine.

Why it matters

Who can join: the full rules

Cohort A:

Inclusion Criteria:

* Current diagnosis of lung cancer with a driver mutation.
* Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.)
* Able and willing to give informed consent.
* Able and willing to complete the screening questionnaire.

Cohort A:

Exclusion Criteria:

* There are no exclusion criteria for Cohort A.

Cohort B:

Inclusion Criteria:

* Age 40 - 80.
* Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial.
* Smoked \< 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year.
* Be able to undergo a low dose chest CT scan.
* If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment.
* Able and willing to provide informed consent.
* Able and willing to comply with the protocol requirements

Cohort B:

Exclusion Criteria:

* Previous history of lung cancers.
* Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis.
* Pregnant at time of enrollment.
* History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised).
* Current smoker.
* Smoked ≥ 20 pack years.
* Had a chest CT scan within 1 year of study entry.

Where it's running

• Chao Family Comprehensive Cancer Center University of California, Irvine
  Orange, California, United States Recruiting

Study contacts

• Study coordinator: Chao Family Comprehensive Cancer Center University of California, Irvine
• Email: ucstudy@uci.edu
• Phone: 1-877-827-8839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.