Advancing proteomics tools to understand the proteasome system
Official title: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome System
Funded at University of California-Irvine · NIH-11529364 · Data updated 2026-11-12
This NIH grant funds researchers to develop better proteomics technologies so scientists can understand how the proteasome system works in humans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $185,352 |
| NIH project number | 3R35GM145249-05S1 |
| Project ID | NIH-11529364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose diseases involve proteasome pathways or who participate in related human sample studies linked to proteasome biology.
✕Less likely to help
Patients not directly touched by proteasome research or who are not involved in related studies may not experience immediate benefit.
What this research studies
Researchers at UC Irvine will refine cutting-edge proteomics methods to study the 20S proteasome and related factors. The project aims to generate more precise tools and data to map proteasome-related processes in human biology. This work could lay the groundwork for future discoveries about how protein breakdown affects health and disease. The grant supports a multi-year effort led by Dr. Lan Huang to push the boundaries of proteolysis research. The plan emphasizes continuing work on the funded parent project with an emphasis on methodological advancement.
Why it matters
Potential benefit: If successful, patients may benefit from deeper insights into protein degradation pathways that are implicated in many diseases.
How similar studies have gone: Previous proteomics tool developments have improved understanding of protein degradation, suggesting potential for meaningful advances with this approach.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Huang, Lan — University of California-Irvine
- Study coordinator: Huang, Lan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.