Center study of how genetic variants affect gene activity in mouse cells
Official title: Center for Mouse Genomic Variation at Single Cell Resolution
Funded at University of California-Irvine · NIH-11516206 · Data updated 2026-11-12
A research center will study how millions of human-like genetic differences influence gene activity in mouse cells to better understand complex diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 24, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,379,016 |
| NIH project number | 3UM1HG012077-05S1 |
| Project ID | NIH-11516206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable here; this is a mouse-based study aimed at improving understanding of human genetics and disease mechanisms.
✕Less likely to help
Direct patient benefits are not guaranteed from a mouse-focused project.
What this research studies
This project uses diverse mouse strains to map which genetic variants change gene expression and chromatin in single cells across eight tissues. It combines single-nucleus sequencing with advanced computer models to connect variants to how genes are turned on or off. The work aims to build resources and tools that help interpret how human genetic variation contributes to health and disease. Findings could improve our understanding of how genetic differences shape disease risk and biology in people.
Why it matters
Potential benefit: If successful, it could improve interpretation of human genetic variation and inform personalized approaches to prevent or treat diseases.
How similar studies have gone: Previous single-cell and cross-species studies have shown that variants can influence gene expression, supporting the approach's potential.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Mortazavi, Seyed Ali — University of California-Irvine
- Study coordinator: Mortazavi, Seyed Ali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.