Vaginal treatment for menopause symptoms using CO2 laser

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of CO2 laser treatment on Genitourinary Syndrome of Menopause (GSM), a condition characterized by vaginal dryness and discomfort due to decreased estrogen levels. Using advanced imaging techniques like optical coherence tomography, the study aims to document changes in the vaginal epithelium before and after treatment. The goal is to provide a non-hormonal alternative for women who cannot use traditional hormone therapies due to health concerns. Participants will be monitored for their response to the laser therapy over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Birth sex: female
2. Desire for vaginal laser therapy for GSM
3. Age \>=18 years old
4. Willingness to forego other treatments for GSM within the study period
5. Diagnosed as postmenopausal (either by surgical removal of ovaries or natural progression defined as no periods in 1 year)

Exclusion Criteria:

1. History of pelvic radiation
2. On hormone replacement therapy in the prior 3 months
3. Not able or willing to follow study instructions
4. Current diagnosis of recurrent UTIs

Where it's running

• Beckman Laser Institute
  Irvine, California, United States Recruiting

Study contacts

• Principal investigator: Felicia Lane, MD — University of California, Irvine
• Study coordinator: Karla LORENTE, MD
• Email: klorente@hs.uci.edu
• Phone: 714-798-9044

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Burden of vaginal and urinary menopause symptoms in breast cancer survivors

  This study will see how common and how severe genitourinary menopause symptoms are in breast cancer survivors receiving single-mode cancer treatment compared with controls.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT07563621

• Nonhormonal vulvovaginal gel to relieve menopausal vulvovaginal symptoms

  This will test a hormone-free vulvovaginal gel in postmenopausal women with genitourinary syndrome of menopause to see if it reduces vaginal atrophy symptoms and improves daily quality of life.

  Recruiting Mucosa Innovations, S.L. · Madrid, Madrid · NCT06962345

• Combining topical hyaluronic acid with high-concentration oxygen therapy for menopausal symptoms

  This study is testing if a treatment that combines a special gel and high-concentration oxygen can help postmenopausal women, including those who had breast cancer, feel better by reducing vaginal dryness and other symptoms.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT06879938

• Er:YAG laser plus vaginal estriol for menopausal genitourinary symptoms

  This trial will test whether adding Er:YAG laser treatment to low‑dose vaginal estriol helps postmenopausal women with genitourinary syndrome of menopause.

  Recruiting University of Nove de Julho · São Paulo, São Paulo · NCT06873971

• Telerehabilitation program for improving sexual function and reducing pain in menopausal women

  This study is testing a telerehabilitation program to see if it can help menopausal women with painful sex feel better and improve their overall quality of life compared to regular in-person therapy.

  Recruiting Instituto Médico Tecnológico SL · Barcelona, Spain · NCT06710002

• Laser therapy for vaginal symptoms in breast cancer survivors

  This study is testing whether laser therapy can help breast cancer survivors who have vaginal symptoms feel better.

  Recruiting University of Aarhus · Randers · NCT06007027

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.